BacMap

Definition	Exiguobacterium sp. AT1b, complete genome.
Accession	NC_012673
Length	2,999,895

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The map label for this gene is ppiB [H]

Identifier: 229916179

GI number: 229916179

Start: 409991

End: 410431

Strand: Reverse

Name: ppiB [H]

Synonym: EAT1b_0448

Alternate gene names: 229916179

Gene position: 410431-409991 (Counterclockwise)

Preceding gene: 229916180

Following gene: 229916178

Centisome position: 13.68

GC content: 47.39

Gene sequence:

>441_bases
ATGAAAAAAGGTTCTATGAAACTTGAAAATGGCGAAATGATTGAATTTGATTTATTCCACGGTGAAGCACCGATTACGGT
CGAAAACTTCGAAAAACTTGCGAACAGTGGGTTTTACAACGGATTGACGTTCCACCGTGTCATCCCTGGCTTCGTTAGCC
AAGGTGGTTGCCCACAAGGAACTGGAATGGGCGGTGCAGGCTATACGATTCCTTGTGAGACATCGACATCGTTCCCGCAC
AAACATGAAGCGGGTTCACTTTCAATGGCCCACGCAGGTCGTAACACAGGGTCTTCACAGTTCTTCATCGTCCATGAGCC
ACAACCGCATTTGGATGGTGTCCATACGGTATTCGGTAAAGTGACATCTGGTCTTGAGCATGCCGTCAAACTTCGTCAAG
GTACGAAGATGGCAGAAGTGAAGGTTTGGGACGAGAATTGA

Upstream 100 bases:

>100_bases
TTCCACAAAAAAGTGGAGACAGACGTGTTTTTTTGATAAGATGGGTAATGTGAGTGTCAAACAGCAGGATACATATTATG
AAAAAGGGGTTGCTTGAAAC

Downstream 100 bases:

>100_bases
TTTTTGCCTGAAGGGTATGGCACAATGAACCATGTCTCTCACGTGTTCACGTCGTGAAACTTGAATGACAAAAGGTGGTG
AACCCAGCGATGCTGGTCAA

Product: peptidyl-prolyl cis-trans isomerase cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKKGSMKLENGEMIEFDLFHGEAPITVENFEKLANSGFYNGLTFHRVIPGFVSQGGCPQGTGMGGAGYTIPCETSTSFPH
KHEAGSLSMAHAGRNTGSSQFFIVHEPQPHLDGVHTVFGKVTSGLEHAVKLRQGTKMAEVKVWDEN

Sequences:

>Translated_146_residues
MKKGSMKLENGEMIEFDLFHGEAPITVENFEKLANSGFYNGLTFHRVIPGFVSQGGCPQGTGMGGAGYTIPCETSTSFPH
KHEAGSLSMAHAGRNTGSSQFFIVHEPQPHLDGVHTVFGKVTSGLEHAVKLRQGTKMAEVKVWDEN
>Mature_146_residues
MKKGSMKLENGEMIEFDLFHGEAPITVENFEKLANSGFYNGLTFHRVIPGFVSQGGCPQGTGMGGAGYTIPCETSTSFPH
KHEAGSLSMAHAGRNTGSSQFFIVHEPQPHLDGVHTVFGKVTSGLEHAVKLRQGTKMAEVKVWDEN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=112, Percent_Identity=51.7857142857143, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI19557636, Length=123, Percent_Identity=46.3414634146341, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI7706339, Length=115, Percent_Identity=46.0869565217391, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI10863927, Length=117, Percent_Identity=45.2991452991453, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI6631100, Length=126, Percent_Identity=43.6507936507937, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI64276486, Length=118, Percent_Identity=38.9830508474576, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI4826932, Length=125, Percent_Identity=41.6, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4758950, Length=126, Percent_Identity=44.4444444444444, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310127646, Length=145, Percent_Identity=39.3103448275862, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310114371, Length=145, Percent_Identity=39.3103448275862, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310119221, Length=145, Percent_Identity=39.3103448275862, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI42560244, Length=126, Percent_Identity=40.4761904761905, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310129267, Length=117, Percent_Identity=43.5897435897436, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310120620, Length=117, Percent_Identity=43.5897435897436, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=44.9612403100775, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI256017253, Length=114, Percent_Identity=43.859649122807, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI221139811, Length=114, Percent_Identity=43.859649122807, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI256017251, Length=114, Percent_Identity=43.859649122807, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI310110104, Length=117, Percent_Identity=43.5897435897436, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI45439316, Length=134, Percent_Identity=40.2985074626866, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI150418007, Length=124, Percent_Identity=41.1290322580645, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5174637, Length=129, Percent_Identity=40.3100775193798, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI303305009, Length=135, Percent_Identity=37.7777777777778, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI178057341, Length=114, Percent_Identity=42.9824561403509, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=42.8571428571429, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5454154, Length=127, Percent_Identity=40.1574803149606, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI209417936, Length=113, Percent_Identity=42.4778761061947, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI30102944, Length=113, Percent_Identity=42.4778761061947, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI219842199, Length=113, Percent_Identity=42.4778761061947, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI20911035, Length=128, Percent_Identity=35.9375, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310127745, Length=119, Percent_Identity=41.1764705882353, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310119290, Length=119, Percent_Identity=41.1764705882353, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310114540, Length=117, Percent_Identity=41.8803418803419, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI239751853, Length=141, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI113428306, Length=141, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI169214050, Length=141, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI169164185, Length=118, Percent_Identity=39.8305084745763, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI169163623, Length=118, Percent_Identity=39.8305084745763, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI169163387, Length=118, Percent_Identity=39.8305084745763, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI310132444, Length=143, Percent_Identity=37.7622377622378, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI310113152, Length=143, Percent_Identity=37.7622377622378, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1789763, Length=136, Percent_Identity=38.9705882352941, Blast_Score=76, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=116, Percent_Identity=48.2758620689655, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506311, Length=124, Percent_Identity=44.3548387096774, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=113, Percent_Identity=41.5929203539823, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=115, Percent_Identity=40.8695652173913, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=115, Percent_Identity=40.8695652173913, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=113, Percent_Identity=41.5929203539823, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506307, Length=129, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551282, Length=133, Percent_Identity=42.8571428571429, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551284, Length=133, Percent_Identity=42.8571428571429, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=148, Percent_Identity=36.4864864864865, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=125, Percent_Identity=40, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=151, Percent_Identity=38.4105960264901, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=130, Percent_Identity=36.9230769230769, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=132, Percent_Identity=37.8787878787879, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=118, Percent_Identity=41.5254237288136, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=128, Percent_Identity=40.625, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552784, Length=124, Percent_Identity=37.9032258064516, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=129, Percent_Identity=36.4341085271318, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=118, Percent_Identity=47.4576271186441, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320359, Length=125, Percent_Identity=44.8, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320510, Length=134, Percent_Identity=40.2985074626866, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=136, Percent_Identity=43.3823529411765, Blast_Score=77, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323246, Length=125, Percent_Identity=41.6, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=121, Percent_Identity=43.801652892562, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922376, Length=134, Percent_Identity=41.044776119403, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650807, Length=126, Percent_Identity=43.6507936507937, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20130249, Length=117, Percent_Identity=45.2991452991453, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922912, Length=116, Percent_Identity=50, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652460, Length=123, Percent_Identity=36.5853658536585, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357249, Length=131, Percent_Identity=34.3511450381679, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17647301, Length=119, Percent_Identity=43.6974789915966, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=43.6507936507937, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=43.6507936507937, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=43.6507936507937, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586038, Length=127, Percent_Identity=40.1574803149606, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355677, Length=125, Percent_Identity=39.2, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136360, Length=121, Percent_Identity=38.0165289256198, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15806; Mature: 15806

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSMKLENGEMIEFDLFHGEAPITVENFEKLANSGFYNGLTFHRVIPGFVSQGGCPQG
CCCCCEEECCCCEEEEEEECCCCCEEHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCC
TGMGGAGYTIPCETSTSFPHKHEAGSLSMAHAGRNTGSSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
VTSGLEHAVKLRQGTKMAEVKVWDEN
HHHHHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MKKGSMKLENGEMIEFDLFHGEAPITVENFEKLANSGFYNGLTFHRVIPGFVSQGGCPQG
CCCCCEEECCCCEEEEEEECCCCCEEHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCC
TGMGGAGYTIPCETSTSFPHKHEAGSLSMAHAGRNTGSSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
VTSGLEHAVKLRQGTKMAEVKVWDEN
HHHHHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]