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The map label for this gene is tdh [H]

Identifier: 229916156

GI number: 229916156

Start: 388067

End: 389143

Strand: Reverse

Name: tdh [H]

Synonym: EAT1b_0425

Alternate gene names: 229916156

Gene position: 389143-388067 (Counterclockwise)

Preceding gene: 229916157

Following gene: 229916155

Centisome position: 12.97

GC content: 52.55

Gene sequence:

>1077_bases
ATGGAACAACTTGTGTCAACCAAAGAGACGGAATCAACGACACCAGTAATGAAAGCGATTCAAAAACACACGGCCGGGTT
TGGGGCAAAACTGGTCGACGTACCAGTTCCGACACCAGGACCTGGAGAAGTACTCATTCAAGTTAAAGCGACATCGATTT
GCGGGACCGATGTCCATATCTATGAATGGGATGAATGGTCGCAAAGCCGCGTCAAACCACCGTACGTATTCGGTCATGAG
TTTTCGGGGGAGGTCGTTGCGCTCGGCGAAGGGACGAAACGGATCAAAGTCGGACAGGCGGTGTCTGCTGAAACACATAT
CGTCTGTCATCAATGTAAGCAATGTTTGCGCGGTCAGTACCACATCTGTAAAAACACAAAAATCATCGGTGTGGACACGC
AAGGATGTTTCGCAGAATATGTCGTCATGCCTGAAGAGAATCTATGGGTGAACCCGGAGTCGATGCCAGCGAAACTCGCC
TCGATTCAAGAACCACTCGGGAATGCGGTCCATACGGTATTGGCGAGTGATGTATCGGCCAAATCGGTCGCCATCGTCGG
TTGTGGACCGATCGGACTCATGGCGGTCGGTGTCGCCAAAGCAGCAGGGGCGAGTCTTGTCTATGCGATTGACGTCAATC
CATATCGTTTAAAACTCGCCGAAGCGATGGGGGCAGATGTCGTCATCAACAGTTTAGAAGAGAATCCGCTCGAGTTGATC
GAGCGTGAGACCGACGGAGACGGAATCGATGTCGTCTGTGAGATGAGCGGACACCCGATTGCGATCGATCAGGCGTTCAA
GATGGTCACGGCAGGTGGGGACGTCAACGTCTTGTCACTTCCGGCTCGTCCGGTCGCCATCGACCTCACACGGGATGTCG
TCTTTAAAGGGGTCCGCGTCCAGGGCATCACGGGCCGCAAGATGTATGAAACGTGGAGTCAAGTCTCGACGATGCTTGCG
ACGGGTCAGTTGAACGTCGAACCGATCATCACGCACGTCTTCAAGCTCGAAGAGTTCGAAAAAGGGTTCGAACTCATGCG
GGCAGGGAAATGTGGAAAGGTCGTCTTAATACCTTAA

Upstream 100 bases:

>100_bases
GTGTAAATCGGACGTTCCATCTTCTCAGTTTCGTCATTTTATGACAAGATGATAAAGAACGTATCGTTCGATCATGAGAA
ACAAGAGGGGGACGTTTTCA

Downstream 100 bases:

>100_bases
AGGGGGAAACAACATGGCATTTGAACATATTACAGAAGCAATCAATGAGATGAAAGAGCAGGGGACGTTCCGTAAGCTCG
TCCCGCTCGAATCGGCACAA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MEQLVSTKETESTTPVMKAIQKHTAGFGAKLVDVPVPTPGPGEVLIQVKATSICGTDVHIYEWDEWSQSRVKPPYVFGHE
FSGEVVALGEGTKRIKVGQAVSAETHIVCHQCKQCLRGQYHICKNTKIIGVDTQGCFAEYVVMPEENLWVNPESMPAKLA
SIQEPLGNAVHTVLASDVSAKSVAIVGCGPIGLMAVGVAKAAGASLVYAIDVNPYRLKLAEAMGADVVINSLEENPLELI
ERETDGDGIDVVCEMSGHPIAIDQAFKMVTAGGDVNVLSLPARPVAIDLTRDVVFKGVRVQGITGRKMYETWSQVSTMLA
TGQLNVEPIITHVFKLEEFEKGFELMRAGKCGKVVLIP

Sequences:

>Translated_358_residues
MEQLVSTKETESTTPVMKAIQKHTAGFGAKLVDVPVPTPGPGEVLIQVKATSICGTDVHIYEWDEWSQSRVKPPYVFGHE
FSGEVVALGEGTKRIKVGQAVSAETHIVCHQCKQCLRGQYHICKNTKIIGVDTQGCFAEYVVMPEENLWVNPESMPAKLA
SIQEPLGNAVHTVLASDVSAKSVAIVGCGPIGLMAVGVAKAAGASLVYAIDVNPYRLKLAEAMGADVVINSLEENPLELI
ERETDGDGIDVVCEMSGHPIAIDQAFKMVTAGGDVNVLSLPARPVAIDLTRDVVFKGVRVQGITGRKMYETWSQVSTMLA
TGQLNVEPIITHVFKLEEFEKGFELMRAGKCGKVVLIP
>Mature_358_residues
MEQLVSTKETESTTPVMKAIQKHTAGFGAKLVDVPVPTPGPGEVLIQVKATSICGTDVHIYEWDEWSQSRVKPPYVFGHE
FSGEVVALGEGTKRIKVGQAVSAETHIVCHQCKQCLRGQYHICKNTKIIGVDTQGCFAEYVVMPEENLWVNPESMPAKLA
SIQEPLGNAVHTVLASDVSAKSVAIVGCGPIGLMAVGVAKAAGASLVYAIDVNPYRLKLAEAMGADVVINSLEENPLELI
ERETDGDGIDVVCEMSGHPIAIDQAFKMVTAGGDVNVLSLPARPVAIDLTRDVVFKGVRVQGITGRKMYETWSQVSTMLA
TGQLNVEPIITHVFKLEEFEKGFELMRAGKCGKVVLIP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=29.2168674698795, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI156523966, Length=355, Percent_Identity=27.0422535211268, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=25.3481894150418, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=27.0114942528736, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71743840, Length=356, Percent_Identity=27.247191011236, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI262073058, Length=356, Percent_Identity=27.247191011236, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=24.2339832869081, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=25.3521126760563, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=24.2339832869081, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=25.1322751322751, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=45.2941176470588, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1788073, Length=319, Percent_Identity=28.5266457680251, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788075, Length=359, Percent_Identity=29.2479108635098, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=29.8816568047337, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=29.7619047619048, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI87082125, Length=336, Percent_Identity=30.952380952381, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786825, Length=399, Percent_Identity=28.8220551378446, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=28.525641025641, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=24.4372990353698, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=29.5890410958904, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081918, Length=264, Percent_Identity=29.5454545454545, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=29.673590504451, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=29.080118694362, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71988145, Length=328, Percent_Identity=26.219512195122, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=24.5179063360882, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=24.3835616438356, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=111, Percent_Identity=30.6306306306306, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=24.4117647058824, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=23.7082066869301, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=319, Percent_Identity=30.7210031347962, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=319, Percent_Identity=30.7210031347962, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=28.6153846153846, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319257, Length=268, Percent_Identity=30.2238805970149, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=361, Percent_Identity=28.5318559556787, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=26.3586956521739, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=257, Percent_Identity=31.1284046692607, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=29.8461538461538, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=277, Percent_Identity=30.3249097472924, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=276, Percent_Identity=29.3478260869565, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=269, Percent_Identity=29.368029739777, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=298, Percent_Identity=25.8389261744966, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=26.3473053892216, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17737897, Length=354, Percent_Identity=25.1412429378531, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=27.6712328767123, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550770, Length=320, Percent_Identity=25.625, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221457811, Length=320, Percent_Identity=25.625, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551930, Length=320, Percent_Identity=25.625, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38538; Mature: 38538

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLVSTKETESTTPVMKAIQKHTAGFGAKLVDVPVPTPGPGEVLIQVKATSICGTDVHI
CCCHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCEEEE
YEWDEWSQSRVKPPYVFGHEFSGEVVALGEGTKRIKVGQAVSAETHIVCHQCKQCLRGQY
EECCCCCCCCCCCCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCE
HICKNTKIIGVDTQGCFAEYVVMPEENLWVNPESMPAKLASIQEPLGNAVHTVLASDVSA
EEECCCEEEEECCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KSVAIVGCGPIGLMAVGVAKAAGASLVYAIDVNPYRLKLAEAMGADVVINSLEENPLELI
CEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHEEEEHHHCCCCEEEECCCCCHHHHH
ERETDGDGIDVVCEMSGHPIAIDQAFKMVTAGGDVNVLSLPARPVAIDLTRDVVFKGVRV
HCCCCCCCEEEEEECCCCEEEHHHHEEEEECCCCEEEEEECCCCEEEEEEHHHHHCCEEE
QGITGRKMYETWSQVSTMLATGQLNVEPIITHVFKLEEFEKGFELMRAGKCGKVVLIP
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MEQLVSTKETESTTPVMKAIQKHTAGFGAKLVDVPVPTPGPGEVLIQVKATSICGTDVHI
CCCHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEEEEECCCEEEE
YEWDEWSQSRVKPPYVFGHEFSGEVVALGEGTKRIKVGQAVSAETHIVCHQCKQCLRGQY
EECCCCCCCCCCCCEEECCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCE
HICKNTKIIGVDTQGCFAEYVVMPEENLWVNPESMPAKLASIQEPLGNAVHTVLASDVSA
EEECCCEEEEECCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KSVAIVGCGPIGLMAVGVAKAAGASLVYAIDVNPYRLKLAEAMGADVVINSLEENPLELI
CEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHEEEEHHHCCCCEEEECCCCCHHHHH
ERETDGDGIDVVCEMSGHPIAIDQAFKMVTAGGDVNVLSLPARPVAIDLTRDVVFKGVRV
HCCCCCCCEEEEEECCCCEEEHHHHEEEEECCCCEEEEEECCCCEEEEEEHHHHHCCEEE
QGITGRKMYETWSQVSTMLATGQLNVEPIITHVFKLEEFEKGFELMRAGKCGKVVLIP
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA