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The map label for this gene is kbl [C]

Identifier: 229916155

GI number: 229916155

Start: 386872

End: 388053

Strand: Reverse

Name: kbl [C]

Synonym: EAT1b_0424

Alternate gene names: 229916155

Gene position: 388053-386872 (Counterclockwise)

Preceding gene: 229916156

Following gene: 229916154

Centisome position: 12.94

GC content: 54.65

Gene sequence:

>1182_bases
ATGGCATTTGAACATATTACAGAAGCAATCAATGAGATGAAAGAGCAGGGGACGTTCCGTAAGCTCGTCCCGCTCGAATC
GGCACAAGGGAATGAAGTGACAATCGATGGAAAGTCGCTCGTCCAGCTGTCATCAAACAACTATCTCGGCCTCGCGAATC
ACCCGCGTTTGAAACAGGCGGCGATTGAAGCAGTCGAGCAGTATGGGGCAGGAACAGGGTCGGTCCGTACGATTGCCGGG
ACGTTCGAGATGCACGAAGCGTTCGAGCGTGAACTCGCGGAGTTCAAACATACGGAGGCCTCACTCGTCTTCCAATCAGG
ATTCGCGACGAACCTCGGGGTATTGTCTGCACTGCTTGGACCGGAGGATGTCGTCATCAGTGACGCCCTCAACCATGCGT
CAATCATCGATGGGATTCGTCTCACGAAAGCGGCACGTCGCATCTATAAACACGTCGACCTTGAAGATTTGGAGAAAGCG
TTGAAAGAGACGCAGGACTATCGCACACGTCTCGTCGTGACGGACGGCGTCTTCTCGATGGATGGGAACATCGCACCGCT
TCCTGCCATCGTCGAACTCGCAGAAAAGTATGACGCTGCGGTCATGGTCGATGATGCGCATGCATCCGGCGTCCTCGGGA
AGAACGGACGGGGAACCGTCAACCACTTCGGATTGGACGGTCGCGTCGCGTTACAGGTCGGGACGCTCTCAAAAGCAATC
GGTGTCTTAGGTGGCTATGTCGCCTGTTCACAAGACGTTCGCGATTACTTGATTCACAAAGGTCGCCCGTTCCTCTTCTC
GACATCACATCCACCGGCAGTCGTGGCGGCGAACCGTGAAGCGATCCGTGTCATGAAAGAGGAAGAAGAGTTGTTCGACA
AGCTATGGGCGAACACGGAGTTCTTCAAGAACGGTCTACGTGACCTTGGTTTCGATATCGGACATGCGACGACACCGATC
ACACCGGTCATGCTCGGCGAAGAGACGCTTGCGCATACATTCTCAGACAAGTTGAAAGACCATGGCGTATTCGCACAGAG
TATCGCCTTCCCGACGGTCGAGCGTGGGAAAGCACGCATCCGGACCATCGTCACAGCGGAGCATACACGAGACGACCTCG
AACGGGCACTCGAAGCGTTCAAGACGGTCGCGGAAGAGTTGAATGTGACATTACACGCATAA

Upstream 100 bases:

>100_bases
ACGCACGTCTTCAAGCTCGAAGAGTTCGAAAAAGGGTTCGAACTCATGCGGGCAGGGAAATGTGGAAAGGTCGTCTTAAT
ACCTTAAAGGGGGAAACAAC

Downstream 100 bases:

>100_bases
ACGAGGACTGCAGACAATCTGTCTGCAGTTTTTTAGTGGATTGGTCTATGAAATCGAGTATATTCAGATAGAGCACAGAT
GGGGTAAATCGAAATATAGC

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MAFEHITEAINEMKEQGTFRKLVPLESAQGNEVTIDGKSLVQLSSNNYLGLANHPRLKQAAIEAVEQYGAGTGSVRTIAG
TFEMHEAFERELAEFKHTEASLVFQSGFATNLGVLSALLGPEDVVISDALNHASIIDGIRLTKAARRIYKHVDLEDLEKA
LKETQDYRTRLVVTDGVFSMDGNIAPLPAIVELAEKYDAAVMVDDAHASGVLGKNGRGTVNHFGLDGRVALQVGTLSKAI
GVLGGYVACSQDVRDYLIHKGRPFLFSTSHPPAVVAANREAIRVMKEEEELFDKLWANTEFFKNGLRDLGFDIGHATTPI
TPVMLGEETLAHTFSDKLKDHGVFAQSIAFPTVERGKARIRTIVTAEHTRDDLERALEAFKTVAEELNVTLHA

Sequences:

>Translated_393_residues
MAFEHITEAINEMKEQGTFRKLVPLESAQGNEVTIDGKSLVQLSSNNYLGLANHPRLKQAAIEAVEQYGAGTGSVRTIAG
TFEMHEAFERELAEFKHTEASLVFQSGFATNLGVLSALLGPEDVVISDALNHASIIDGIRLTKAARRIYKHVDLEDLEKA
LKETQDYRTRLVVTDGVFSMDGNIAPLPAIVELAEKYDAAVMVDDAHASGVLGKNGRGTVNHFGLDGRVALQVGTLSKAI
GVLGGYVACSQDVRDYLIHKGRPFLFSTSHPPAVVAANREAIRVMKEEEELFDKLWANTEFFKNGLRDLGFDIGHATTPI
TPVMLGEETLAHTFSDKLKDHGVFAQSIAFPTVERGKARIRTIVTAEHTRDDLERALEAFKTVAEELNVTLHA
>Mature_392_residues
AFEHITEAINEMKEQGTFRKLVPLESAQGNEVTIDGKSLVQLSSNNYLGLANHPRLKQAAIEAVEQYGAGTGSVRTIAGT
FEMHEAFERELAEFKHTEASLVFQSGFATNLGVLSALLGPEDVVISDALNHASIIDGIRLTKAARRIYKHVDLEDLEKAL
KETQDYRTRLVVTDGVFSMDGNIAPLPAIVELAEKYDAAVMVDDAHASGVLGKNGRGTVNHFGLDGRVALQVGTLSKAIG
VLGGYVACSQDVRDYLIHKGRPFLFSTSHPPAVVAANREAIRVMKEEEELFDKLWANTEFFKNGLRDLGFDIGHATTPIT
PVMLGEETLAHTFSDKLKDHGVFAQSIAFPTVERGKARIRTIVTAEHTRDDLERALEAFKTVAEELNVTLHA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=376, Percent_Identity=42.2872340425532, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=43.5158501440922, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=34.0540540540541, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI83977444, Length=367, Percent_Identity=33.7874659400545, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI83977442, Length=367, Percent_Identity=33.7874659400545, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI83977440, Length=367, Percent_Identity=33.7874659400545, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=33.7837837837838, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4502025, Length=362, Percent_Identity=33.4254143646409, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI40316939, Length=362, Percent_Identity=33.4254143646409, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI5454084, Length=379, Percent_Identity=29.8153034300792, Blast_Score=168, Evalue=8e-42,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=42.9667519181586, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=35.933147632312, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=41.7948717948718, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=28.7671232876712, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=28.133704735376, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=28.133704735376, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71982617, Length=383, Percent_Identity=27.154046997389, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982625, Length=383, Percent_Identity=27.154046997389, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=34.9462365591398, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=32.0652173913043, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=26.6903914590747, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24662918, Length=380, Percent_Identity=43.9473684210526, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI17137420, Length=358, Percent_Identity=33.2402234636872, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17136286, Length=401, Percent_Identity=29.6758104738155, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24653280, Length=390, Percent_Identity=26.1538461538462, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24653276, Length=390, Percent_Identity=26.1538461538462, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24653278, Length=390, Percent_Identity=26.1538461538462, Blast_Score=138, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42976; Mature: 42845

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEHITEAINEMKEQGTFRKLVPLESAQGNEVTIDGKSLVQLSSNNYLGLANHPRLKQA
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEECCHHEEEECCCCEEECCCCCHHHHH
AIEAVEQYGAGTGSVRTIAGTFEMHEAFERELAEFKHTEASLVFQSGFATNLGVLSALLG
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHCC
PEDVVISDALNHASIIDGIRLTKAARRIYKHVDLEDLEKALKETQDYRTRLVVTDGVFSM
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCEEEC
DGNIAPLPAIVELAEKYDAAVMVDDAHASGVLGKNGRGTVNHFGLDGRVALQVGTLSKAI
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHH
GVLGGYVACSQDVRDYLIHKGRPFLFSTSHPPAVVAANREAIRVMKEEEELFDKLWANTE
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHH
FFKNGLRDLGFDIGHATTPITPVMLGEETLAHTFSDKLKDHGVFAQSIAFPTVERGKARI
HHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHCCCCHHCCHHHH
RTIVTAEHTRDDLERALEAFKTVAEELNVTLHA
HEEEEHHHHHHHHHHHHHHHHHHHHHHCEEECC
>Mature Secondary Structure 
AFEHITEAINEMKEQGTFRKLVPLESAQGNEVTIDGKSLVQLSSNNYLGLANHPRLKQA
CHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEECCHHEEEECCCCEEECCCCCHHHHH
AIEAVEQYGAGTGSVRTIAGTFEMHEAFERELAEFKHTEASLVFQSGFATNLGVLSALLG
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHCC
PEDVVISDALNHASIIDGIRLTKAARRIYKHVDLEDLEKALKETQDYRTRLVVTDGVFSM
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCEEEC
DGNIAPLPAIVELAEKYDAAVMVDDAHASGVLGKNGRGTVNHFGLDGRVALQVGTLSKAI
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHH
GVLGGYVACSQDVRDYLIHKGRPFLFSTSHPPAVVAANREAIRVMKEEEELFDKLWANTE
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHH
FFKNGLRDLGFDIGHATTPITPVMLGEETLAHTFSDKLKDHGVFAQSIAFPTVERGKARI
HHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHCCCCHHCCHHHH
RTIVTAEHTRDDLERALEAFKTVAEELNVTLHA
HEEEEHHHHHHHHHHHHHHHHHHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA