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The map label for this gene is yhaU [H]

Identifier: 229916094

GI number: 229916094

Start: 324101

End: 325270

Strand: Direct

Name: yhaU [H]

Synonym: EAT1b_0363

Alternate gene names: 229916094

Gene position: 324101-325270 (Clockwise)

Preceding gene: 229916093

Following gene: 229916096

Centisome position: 10.8

GC content: 46.58

Gene sequence:

>1170_bases
ATGGATGGATTAAATATCATCGTGTTGCTCGGATTGGCGCTCACCCTCATCTCTGTCCTCAGTCTCCTGATTGAACGATT
ATTTTTCCCGAGTATTTTAGCGTTTATCGCAATCGGGGTCGGGGTCGGTTTTTTCTGGGATGGGAATGAAGTCTTTAAAG
TCGCGGGAGAGATTGGAATCATTCTTTTATTTTTCCTACTCGGTCTAAAGTTTCCACTACGTGAACTTTGGAAGCGCATG
CGGAAAGTGTGGAAGGCGGGAATACTCGATATCATTCTGTCATTCGGAGTATCGTTCGGGATTGCATTAGCATTTGGTCT
CGACTTCCCTCGCGCCTTTTTAATCGGGGCCGTCTTATATGCGACGAGCTCCTCCATCTCTGCGAAGCTGCTTGAGCGGC
ATTCCGAAAAACATGAAGATATTAAAGAGTTTGTGCTCGCATTACTGATCTTTGAGGATATTTTTGCCCCACTGCTCTTG
ACGGTCGCCCCTTTCATCATCCAAGAAGAACCGGTTGCGATGTCCGATATCGGAAAAGTGTTCGCAGGATTTCTTATATT
TGGCGTACTCTTGTTCATCGGTTCAAGCTTCGTATCCAAGCAACAAAAATTTTCGAAGCACTTACTGCGACAAGATGATG
CGAGCATCGGTCTGATTGGACTCATTCTCTTTTTCGCGGGAATCGGCATGGTGTTTGGATTATCTGAGATTTTAGGGGCA
TTTATCGCCGGGATCATGCTCGCCGATATCCACGATGTGAGACCGCTCAAGCGTTTGACCGTACCCGTCCGAGATTTATT
CTTGCCGATCTTTTTCATTTCGTTCGGAATCTCGATCAACCTCGAGAAAGGCGTCATCGTAAATGCACTCTTCTTCGTCT
TGATTGTGTGGGGAGTATTATCCAAATGGATTGTCGGACGCGTCGGGGGCAGAATCTATGGCTTGACGCGTGTTCAAGCC
AATGAAGCCGGGTTCTCACTCGCGCCACGTGGGGAGTTCTCTATTTTATTTACCGCCCTTTCGAACGGGGCCATCAACTT
GTTTGTCGGTCTCTATATTTTCGTGTCAGCCATTGTCGGAATCATTCTGTTCCGTTTCTCAGAGTACTTGGCAGAAAAAA
CGGAGAAAACCCTCACGAAAGTCTTACCTGACGAGAAAAAAGAAGAATGA

Upstream 100 bases:

>100_bases
CGACAGTTCGGTTTTGATTACTCACGACCTGAATCCGTCGGAATGGAGTATCAATGGAATCAAAGAGAAAGCTAATTGGG
GTCATGAGAGGAGATGACGT

Downstream 100 bases:

>100_bases
ATTGGCGGACCCATACGCTGGGTCCGCCTGTTTTGTGCGTTAGTCTTTCGCTAGTTTGTTGTGCCGTTTTTTACGCCATA
CGATATAGATGATGACCCCG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDGLNIIVLLGLALTLISVLSLLIERLFFPSILAFIAIGVGVGFFWDGNEVFKVAGEIGIILLFFLLGLKFPLRELWKRM
RKVWKAGILDIILSFGVSFGIALAFGLDFPRAFLIGAVLYATSSSISAKLLERHSEKHEDIKEFVLALLIFEDIFAPLLL
TVAPFIIQEEPVAMSDIGKVFAGFLIFGVLLFIGSSFVSKQQKFSKHLLRQDDASIGLIGLILFFAGIGMVFGLSEILGA
FIAGIMLADIHDVRPLKRLTVPVRDLFLPIFFISFGISINLEKGVIVNALFFVLIVWGVLSKWIVGRVGGRIYGLTRVQA
NEAGFSLAPRGEFSILFTALSNGAINLFVGLYIFVSAIVGIILFRFSEYLAEKTEKTLTKVLPDEKKEE

Sequences:

>Translated_389_residues
MDGLNIIVLLGLALTLISVLSLLIERLFFPSILAFIAIGVGVGFFWDGNEVFKVAGEIGIILLFFLLGLKFPLRELWKRM
RKVWKAGILDIILSFGVSFGIALAFGLDFPRAFLIGAVLYATSSSISAKLLERHSEKHEDIKEFVLALLIFEDIFAPLLL
TVAPFIIQEEPVAMSDIGKVFAGFLIFGVLLFIGSSFVSKQQKFSKHLLRQDDASIGLIGLILFFAGIGMVFGLSEILGA
FIAGIMLADIHDVRPLKRLTVPVRDLFLPIFFISFGISINLEKGVIVNALFFVLIVWGVLSKWIVGRVGGRIYGLTRVQA
NEAGFSLAPRGEFSILFTALSNGAINLFVGLYIFVSAIVGIILFRFSEYLAEKTEKTLTKVLPDEKKEE
>Mature_389_residues
MDGLNIIVLLGLALTLISVLSLLIERLFFPSILAFIAIGVGVGFFWDGNEVFKVAGEIGIILLFFLLGLKFPLRELWKRM
RKVWKAGILDIILSFGVSFGIALAFGLDFPRAFLIGAVLYATSSSISAKLLERHSEKHEDIKEFVLALLIFEDIFAPLLL
TVAPFIIQEEPVAMSDIGKVFAGFLIFGVLLFIGSSFVSKQQKFSKHLLRQDDASIGLIGLILFFAGIGMVFGLSEILGA
FIAGIMLADIHDVRPLKRLTVPVRDLFLPIFFISFGISINLEKGVIVNALFFVLIVWGVLSKWIVGRVGGRIYGLTRVQA
NEAGFSLAPRGEFSILFTALSNGAINLFVGLYIFVSAIVGIILFRFSEYLAEKTEKTLTKVLPDEKKEE

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=387, Percent_Identity=25.0645994832041, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789749, Length=373, Percent_Identity=26.0053619302949, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42903; Mature: 42903

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGLNIIVLLGLALTLISVLSLLIERLFFPSILAFIAIGVGVGFFWDGNEVFKVAGEIGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
ILLFFLLGLKFPLRELWKRMRKVWKAGILDIILSFGVSFGIALAFGLDFPRAFLIGAVLY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ATSSSISAKLLERHSEKHEDIKEFVLALLIFEDIFAPLLLTVAPFIIQEEPVAMSDIGKV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FAGFLIFGVLLFIGSSFVSKQQKFSKHLLRQDDASIGLIGLILFFAGIGMVFGLSEILGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIAGIMLADIHDVRPLKRLTVPVRDLFLPIFFISFGISINLEKGVIVNALFFVLIVWGVL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHH
SKWIVGRVGGRIYGLTRVQANEAGFSLAPRGEFSILFTALSNGAINLFVGLYIFVSAIVG
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IILFRFSEYLAEKTEKTLTKVLPDEKKEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDGLNIIVLLGLALTLISVLSLLIERLFFPSILAFIAIGVGVGFFWDGNEVFKVAGEIGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHH
ILLFFLLGLKFPLRELWKRMRKVWKAGILDIILSFGVSFGIALAFGLDFPRAFLIGAVLY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ATSSSISAKLLERHSEKHEDIKEFVLALLIFEDIFAPLLLTVAPFIIQEEPVAMSDIGKV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FAGFLIFGVLLFIGSSFVSKQQKFSKHLLRQDDASIGLIGLILFFAGIGMVFGLSEILGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FIAGIMLADIHDVRPLKRLTVPVRDLFLPIFFISFGISINLEKGVIVNALFFVLIVWGVL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHH
SKWIVGRVGGRIYGLTRVQANEAGFSLAPRGEFSILFTALSNGAINLFVGLYIFVSAIVG
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IILFRFSEYLAEKTEKTLTKVLPDEKKEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]