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The map label for this gene is relA [H]

Identifier: 229916090

GI number: 229916090

Start: 321296

End: 322144

Strand: Reverse

Name: relA [H]

Synonym: EAT1b_0359

Alternate gene names: 229916090

Gene position: 322144-321296 (Counterclockwise)

Preceding gene: 229916091

Following gene: 229916089

Centisome position: 10.74

GC content: 47.82

Gene sequence:

>849_bases
ATGAACCCGCTCGTAGAAGAGGCGTTACGTTTTTCGTCTATTCGTCACGGAGGACAGTTCCGAAAAGGTTCATCCATACC
ATTTTTGTCACACCCATTCTCGGTCGCCATGCTTCTTGAGTCCGATCATCAAGCACCGGTGGTCGTGGCGGCAGGGTTAC
TCCATGATTTGATTGAGGACACGAAGACGGACCCACAAGAAATCTTATCAAAATTCGGATCTGACGTGCACAGGCTCGTT
CTCGCGGTCTCGGAAAAAAATCGTGACGAGTCGTGGGAACAACGAAAACGACTGACACTTCAGCAGGTGAAATCACTTCA
ATTTGATGAAGTCGCACTTCTCGTGGCGGATAAGCTACATAATCTCCGTTCCATCCGTTATGATCTTGAGATGGAAGGGA
TGAAGGTGTGGCAACGTTTTAAACGACCGCTGCGAGACCAATCATGGTATTATCATGAATTACTATCAGCATTTGAACCG
TTTCGGAGTTCGACAGACCTAATCGGTTTGTATGAACAAGAACTCCATCTATTGTTTTACGGCGAGAAAAATTCGAAAGA
TCGAAAAGTGGCAAGACTCTTCGAATCCATGTTGACTCATTTCATCGAGGACGAATGGTTGCAAGAATCGGCACCACTAT
GTCAAACGGCATACGAGTTAAAGGAGATTGTCGGGCGAGAGACGATTGATGAAACAGAGATTGTGTGCTTCCGACAACGA
CTTCACGAAGCAGGTTTGACCACGCCATTGCCACCCGAGAAACTCGCAGGGATGCAAGAACTCGCGTACCGAACGGCTCT
CGAACCACAGCAGATTCTCGCACTCATGCGCCGCTCGATTGTCAACTAG

Upstream 100 bases:

>100_bases
TGTGACCATATACCTAAATTCGAGATGTTTTTAGGTTATATGTACCTAATTCCGGGTAATGAATAGGAGAGTTTTTATCC
GGAAGAAGGAGGATGGCGAC

Downstream 100 bases:

>100_bases
TTCTCTTCATGCTATAGTCAAAAGGAAGATAAAAAGGGGAGTAGCGACCACAGTTGTGGTCGATGGGTCGTCATTACAGT
GCATACGCACTCGGTCCATC

Product: Guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein

Products: NA

Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNPLVEEALRFSSIRHGGQFRKGSSIPFLSHPFSVAMLLESDHQAPVVVAAGLLHDLIEDTKTDPQEILSKFGSDVHRLV
LAVSEKNRDESWEQRKRLTLQQVKSLQFDEVALLVADKLHNLRSIRYDLEMEGMKVWQRFKRPLRDQSWYYHELLSAFEP
FRSSTDLIGLYEQELHLLFYGEKNSKDRKVARLFESMLTHFIEDEWLQESAPLCQTAYELKEIVGRETIDETEIVCFRQR
LHEAGLTTPLPPEKLAGMQELAYRTALEPQQILALMRRSIVN

Sequences:

>Translated_282_residues
MNPLVEEALRFSSIRHGGQFRKGSSIPFLSHPFSVAMLLESDHQAPVVVAAGLLHDLIEDTKTDPQEILSKFGSDVHRLV
LAVSEKNRDESWEQRKRLTLQQVKSLQFDEVALLVADKLHNLRSIRYDLEMEGMKVWQRFKRPLRDQSWYYHELLSAFEP
FRSSTDLIGLYEQELHLLFYGEKNSKDRKVARLFESMLTHFIEDEWLQESAPLCQTAYELKEIVGRETIDETEIVCFRQR
LHEAGLTTPLPPEKLAGMQELAYRTALEPQQILALMRRSIVN
>Mature_282_residues
MNPLVEEALRFSSIRHGGQFRKGSSIPFLSHPFSVAMLLESDHQAPVVVAAGLLHDLIEDTKTDPQEILSKFGSDVHRLV
LAVSEKNRDESWEQRKRLTLQQVKSLQFDEVALLVADKLHNLRSIRYDLEMEGMKVWQRFKRPLRDQSWYYHELLSAFEP
FRSSTDLIGLYEQELHLLFYGEKNSKDRKVARLFESMLTHFIEDEWLQESAPLCQTAYELKEIVGRETIDETEIVCFRQR
LHEAGLTTPLPPEKLAGMQELAYRTALEPQQILALMRRSIVN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=124, Percent_Identity=37.9032258064516, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25143118, Length=138, Percent_Identity=34.0579710144928, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5; =3.1.7.2 [H]

Molecular weight: Translated: 32778; Mature: 32778

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLVEEALRFSSIRHGGQFRKGSSIPFLSHPFSVAMLLESDHQAPVVVAAGLLHDLIED
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TKTDPQEILSKFGSDVHRLVLAVSEKNRDESWEQRKRLTLQQVKSLQFDEVALLVADKLH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NLRSIRYDLEMEGMKVWQRFKRPLRDQSWYYHELLSAFEPFRSSTDLIGLYEQELHLLFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEE
GEKNSKDRKVARLFESMLTHFIEDEWLQESAPLCQTAYELKEIVGRETIDETEIVCFRQR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LHEAGLTTPLPPEKLAGMQELAYRTALEPQQILALMRRSIVN
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPLVEEALRFSSIRHGGQFRKGSSIPFLSHPFSVAMLLESDHQAPVVVAAGLLHDLIED
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
TKTDPQEILSKFGSDVHRLVLAVSEKNRDESWEQRKRLTLQQVKSLQFDEVALLVADKLH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NLRSIRYDLEMEGMKVWQRFKRPLRDQSWYYHELLSAFEPFRSSTDLIGLYEQELHLLFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEEE
GEKNSKDRKVARLFESMLTHFIEDEWLQESAPLCQTAYELKEIVGRETIDETEIVCFRQR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LHEAGLTTPLPPEKLAGMQELAYRTALEPQQILALMRRSIVN
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8232196 [H]