Click here to switch to the map view.

The map label for this gene is hssS [H]

Identifier: 229916057

GI number: 229916057

Start: 293024

End: 294370

Strand: Direct

Name: hssS [H]

Synonym: EAT1b_0325

Alternate gene names: 229916057

Gene position: 293024-294370 (Clockwise)

Preceding gene: 229916056

Following gene: 229916058

Centisome position: 9.77

GC content: 49.74

Gene sequence:

>1347_bases
ATGAAGACACTCTACACGCGAATCATCGTCACGATGTTCCTGATTTTACTTCTTTCCGGAGCCATCTCTCTGTTGATCAG
CAATGTGGCTTATTATACGTGGTGGCAACCTTCCTATAGCGAGAAGACGGAACGGGTCGCCAAAATGGCGGAGTCGTATG
TCGAGATCCATACCGATTTAGACTATGATGCCTTCTATACCTTTTTAGCCGCAACCGGATACCAACTGGTCGTCGTGGAC
TCGGCAGACGAACGTCGACGCTTTGGCGGTGCATTTCGAGACGAGACCATATCTGATACGGTGATTCAGTCCGTACGGAA
CGGAGCTCCCTATCAGGGAATGCGTGACTTTCCGTTTCATCTCTTCTTGCTCGGATTGTTCGATAATGAATTGACGAACA
CATATGGATTTACACTTGAAAACGGAGACGTCATCTTTATCCGTCCGGACTTGAGTGCCCAAATCCGCGAGTTACATCTG
TTCGTCGGTCTATTTTTCGCACTCGTGACCCTCTTGACATTTGGCCTGATCGCCATTTCGACAAGGTCCTTGGTCCGCCC
ATTGCAGACGCTCACGAAAGCGACCACATCCGTCGCCATGCGTAAAGCTCCGGAACATCTCCCCGTCGAGCGTCAAGATG
AGATCGGGACGTTGGCACGACAATTTCAAAACATGTCGAACGAGATCGATCGGACCGAAGCAAGACAGCGACGATTCGTT
TCGAATGTCTCCCATGAATTCCAATCTCCGTTGACTTCCCTAGTTGGCTATGCAGAAAAATTAGCTGACGGTACGGAAGG
AGAATCGAAGGAATATGCGCGTGTCATCGAACAGGAGACGAAGCGTCTATCCCAATTGACGAGACAACTGCTGCTTTTAT
CACGATTGGATGAAAATCCACCGATTCTCGAAACGAACGTGAATGTGCTTCAATCGGTATCCGAAGTCATTCAAATGAAC
GCCTTCATTCTTGATCAAAAAGGGATTGCCGTCGTTACTGACATCCCACAAGACGTAGTCTTGAAGAGTGACCCGGTTCT
ACTCGCACAAGTTTGGAACAACGTATTGGTGAACGCCGTCCATGCCTCACGTGATGGAGGCACCATCCACATCACCTGTA
CCGTTGATCCGGGTATCGTCATCTCGGTTACGGATGAAGGGATTGGGATGGACGACGAGACAAAAGAGCACCTCTTCGAC
CGCTTCTATCGCGGAGACACGGCTCGAACGAGTCAAGGGACAGGTCTCGGTCTCGCCATCACCTCAGATATCATCGACCT
ACATGGCGGAAACATCACAGTCGAGTCTAGCCTTGGAATCGGCACCACGATCCATCTACATTTTTGA

Upstream 100 bases:

>100_bases
CGGTTGATGTGCATATCAAGCGACTTCGTAATCGGTTCGATCACCCTGCTCTGACAATTCGAACGGTACGAGGTGTCGGA
TACGCACTCGAGGTGAACGG

Downstream 100 bases:

>100_bases
TGTCGTTCATATTCTGTTCATATTGGTTGCGTACACTTCCTTCATCAGCACTTGAAGGAGGTTTTTTTATGCAGTTAGGT
TGGAAAGAGATGTGGAGACA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKTLYTRIIVTMFLILLLSGAISLLISNVAYYTWWQPSYSEKTERVAKMAESYVEIHTDLDYDAFYTFLAATGYQLVVVD
SADERRRFGGAFRDETISDTVIQSVRNGAPYQGMRDFPFHLFLLGLFDNELTNTYGFTLENGDVIFIRPDLSAQIRELHL
FVGLFFALVTLLTFGLIAISTRSLVRPLQTLTKATTSVAMRKAPEHLPVERQDEIGTLARQFQNMSNEIDRTEARQRRFV
SNVSHEFQSPLTSLVGYAEKLADGTEGESKEYARVIEQETKRLSQLTRQLLLLSRLDENPPILETNVNVLQSVSEVIQMN
AFILDQKGIAVVTDIPQDVVLKSDPVLLAQVWNNVLVNAVHASRDGGTIHITCTVDPGIVISVTDEGIGMDDETKEHLFD
RFYRGDTARTSQGTGLGLAITSDIIDLHGGNITVESSLGIGTTIHLHF

Sequences:

>Translated_448_residues
MKTLYTRIIVTMFLILLLSGAISLLISNVAYYTWWQPSYSEKTERVAKMAESYVEIHTDLDYDAFYTFLAATGYQLVVVD
SADERRRFGGAFRDETISDTVIQSVRNGAPYQGMRDFPFHLFLLGLFDNELTNTYGFTLENGDVIFIRPDLSAQIRELHL
FVGLFFALVTLLTFGLIAISTRSLVRPLQTLTKATTSVAMRKAPEHLPVERQDEIGTLARQFQNMSNEIDRTEARQRRFV
SNVSHEFQSPLTSLVGYAEKLADGTEGESKEYARVIEQETKRLSQLTRQLLLLSRLDENPPILETNVNVLQSVSEVIQMN
AFILDQKGIAVVTDIPQDVVLKSDPVLLAQVWNNVLVNAVHASRDGGTIHITCTVDPGIVISVTDEGIGMDDETKEHLFD
RFYRGDTARTSQGTGLGLAITSDIIDLHGGNITVESSLGIGTTIHLHF
>Mature_448_residues
MKTLYTRIIVTMFLILLLSGAISLLISNVAYYTWWQPSYSEKTERVAKMAESYVEIHTDLDYDAFYTFLAATGYQLVVVD
SADERRRFGGAFRDETISDTVIQSVRNGAPYQGMRDFPFHLFLLGLFDNELTNTYGFTLENGDVIFIRPDLSAQIRELHL
FVGLFFALVTLLTFGLIAISTRSLVRPLQTLTKATTSVAMRKAPEHLPVERQDEIGTLARQFQNMSNEIDRTEARQRRFV
SNVSHEFQSPLTSLVGYAEKLADGTEGESKEYARVIEQETKRLSQLTRQLLLLSRLDENPPILETNVNVLQSVSEVIQMN
AFILDQKGIAVVTDIPQDVVLKSDPVLLAQVWNNVLVNAVHASRDGGTIHITCTVDPGIVISVTDEGIGMDDETKEHLFD
RFYRGDTARTSQGTGLGLAITSDIIDLHGGNITVESSLGIGTTIHLHF

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=258, Percent_Identity=34.1085271317829, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=28.6764705882353, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1786600, Length=270, Percent_Identity=31.1111111111111, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788279, Length=259, Percent_Identity=27.4131274131274, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786783, Length=284, Percent_Identity=28.5211267605634, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=27.6450511945392, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=27.5985663082437, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=23.8255033557047, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=31.7796610169492, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=212, Percent_Identity=32.0754716981132, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=26.7206477732794, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=28.0701754385965, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.3109243697479, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=272, Percent_Identity=27.2058823529412, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=264, Percent_Identity=29.9242424242424, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=273, Percent_Identity=25.2747252747253, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=262, Percent_Identity=24.4274809160305, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=26.6949152542373, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=252, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50089; Mature: 50089

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLYTRIIVTMFLILLLSGAISLLISNVAYYTWWQPSYSEKTERVAKMAESYVEIHTDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DYDAFYTFLAATGYQLVVVDSADERRRFGGAFRDETISDTVIQSVRNGAPYQGMRDFPFH
CHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
LFLLGLFDNELTNTYGFTLENGDVIFIRPDLSAQIRELHLFVGLFFALVTLLTFGLIAIS
HHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRSLVRPLQTLTKATTSVAMRKAPEHLPVERQDEIGTLARQFQNMSNEIDRTEARQRRFV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNVSHEFQSPLTSLVGYAEKLADGTEGESKEYARVIEQETKRLSQLTRQLLLLSRLDENP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PILETNVNVLQSVSEVIQMNAFILDQKGIAVVTDIPQDVVLKSDPVLLAQVWNNVLVNAV
CEEECCHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHHHH
HASRDGGTIHITCTVDPGIVISVTDEGIGMDDETKEHLFDRFYRGDTARTSQGTGLGLAI
CCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEE
TSDIIDLHGGNITVESSLGIGTTIHLHF
EHHHHEECCCCEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MKTLYTRIIVTMFLILLLSGAISLLISNVAYYTWWQPSYSEKTERVAKMAESYVEIHTDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DYDAFYTFLAATGYQLVVVDSADERRRFGGAFRDETISDTVIQSVRNGAPYQGMRDFPFH
CHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
LFLLGLFDNELTNTYGFTLENGDVIFIRPDLSAQIRELHLFVGLFFALVTLLTFGLIAIS
HHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRSLVRPLQTLTKATTSVAMRKAPEHLPVERQDEIGTLARQFQNMSNEIDRTEARQRRFV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNVSHEFQSPLTSLVGYAEKLADGTEGESKEYARVIEQETKRLSQLTRQLLLLSRLDENP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PILETNVNVLQSVSEVIQMNAFILDQKGIAVVTDIPQDVVLKSDPVLLAQVWNNVLVNAV
CEEECCHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHHHH
HASRDGGTIHITCTVDPGIVISVTDEGIGMDDETKEHLFDRFYRGDTARTSQGTGLGLAI
CCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEE
TSDIIDLHGGNITVESSLGIGTTIHLHF
EHHHHEECCCCEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA