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The map label for this gene is hssR [H]

Identifier: 229916056

GI number: 229916056

Start: 292362

End: 293027

Strand: Direct

Name: hssR [H]

Synonym: EAT1b_0324

Alternate gene names: 229916056

Gene position: 292362-293027 (Clockwise)

Preceding gene: 229916055

Following gene: 229916057

Centisome position: 9.75

GC content: 50.6

Gene sequence:

>666_bases
ATGCGTATACTCATCGTAGAAGACGACCCATCCATTTTACGCCTTGTGAAGGAGACGTTCGAGGATGCGGGTCATGAGGT
GTTGACGGCGACGGATGGGAACACAGGCGAAGAACTTTTTACAACGCAACCAATCGATGCCGCAATCGTCGACATCATGC
TCCCAGGGCTTGACGGTCGTGAGTTGTGTCGACGACTCAAGGCGACTCTTGATATACCCGTCATCCTACTAACCGCTCTC
GATGAATGGGAGGATAAGCGTCAAGGGTTCGAGCTTGGGGCAGACGACTATGTAACCAAACCTTTCATCCCTGAAGAGTT
ATTGTTCCGATTGCAAGCCGTCTCGCGGCGTTATCAACGCTCGGCCGCTTCACAAATTCAAGCCGGTCCTCTTCGACTCG
ATTTAAGAGAGTACGAGGTGACGCTTGAAGGGCAGCTGTTCTATCTTCCTAAAAAAGAGTTCGAGCTATTATTTCAACTC
GCCTCTTTTCCTGGAAGAGTGTATCGTCGTGAGGAGTTGATCGAGTTGGTATGGGGATTTGATTTCGAGGGGGATGAGCG
AACGGTTGATGTGCATATCAAGCGACTTCGTAATCGGTTCGATCACCCTGCTCTGACAATTCGAACGGTACGAGGTGTCG
GATACGCACTCGAGGTGAACGGATGA

Upstream 100 bases:

>100_bases
ATCAAGAGATGACGAAACAATAAAGCTGATACGACTCGAGGTGACTCCGCATGGGTCACCTCGTTTCGTGTCGAACCTAT
TTTGGAAAGGAACGACCGAT

Downstream 100 bases:

>100_bases
AGACACTCTACACGCGAATCATCGTCACGATGTTCCTGATTTTACTTCTTTCCGGAGCCATCTCTCTGTTGATCAGCAAT
GTGGCTTATTATACGTGGTG

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRILIVEDDPSILRLVKETFEDAGHEVLTATDGNTGEELFTTQPIDAAIVDIMLPGLDGRELCRRLKATLDIPVILLTAL
DEWEDKRQGFELGADDYVTKPFIPEELLFRLQAVSRRYQRSAASQIQAGPLRLDLREYEVTLEGQLFYLPKKEFELLFQL
ASFPGRVYRREELIELVWGFDFEGDERTVDVHIKRLRNRFDHPALTIRTVRGVGYALEVNG

Sequences:

>Translated_221_residues
MRILIVEDDPSILRLVKETFEDAGHEVLTATDGNTGEELFTTQPIDAAIVDIMLPGLDGRELCRRLKATLDIPVILLTAL
DEWEDKRQGFELGADDYVTKPFIPEELLFRLQAVSRRYQRSAASQIQAGPLRLDLREYEVTLEGQLFYLPKKEFELLFQL
ASFPGRVYRREELIELVWGFDFEGDERTVDVHIKRLRNRFDHPALTIRTVRGVGYALEVNG
>Mature_221_residues
MRILIVEDDPSILRLVKETFEDAGHEVLTATDGNTGEELFTTQPIDAAIVDIMLPGLDGRELCRRLKATLDIPVILLTAL
DEWEDKRQGFELGADDYVTKPFIPEELLFRLQAVSRRYQRSAASQIQAGPLRLDLREYEVTLEGQLFYLPKKEFELLFQL
ASFPGRVYRREELIELVWGFDFEGDERTVDVHIKRLRNRFDHPALTIRTVRGVGYALEVNG

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=36.697247706422, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=39.8190045248869, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=40.9691629955947, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=35.5555555555556, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=38.8127853881278, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.6846846846847, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.7758620689655, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=33.7777777777778, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=35.3711790393013, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=32.2869955156951, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=30.7339449541284, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=35.7142857142857, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=122, Percent_Identity=30.327868852459, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25421; Mature: 25421

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDDPSILRLVKETFEDAGHEVLTATDGNTGEELFTTQPIDAAIVDIMLPGLDGR
CEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCHH
ELCRRLKATLDIPVILLTALDEWEDKRQGFELGADDYVTKPFIPEELLFRLQAVSRRYQR
HHHHHHHHHCCCHHHEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SAASQIQAGPLRLDLREYEVTLEGQLFYLPKKEFELLFQLASFPGRVYRREELIELVWGF
HHHHHCCCCCEEEEEEEEEEEECCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DFEGDERTVDVHIKRLRNRFDHPALTIRTVRGVGYALEVNG
CCCCCCEEHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECC
>Mature Secondary Structure
MRILIVEDDPSILRLVKETFEDAGHEVLTATDGNTGEELFTTQPIDAAIVDIMLPGLDGR
CEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCCHH
ELCRRLKATLDIPVILLTALDEWEDKRQGFELGADDYVTKPFIPEELLFRLQAVSRRYQR
HHHHHHHHHCCCHHHEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SAASQIQAGPLRLDLREYEVTLEGQLFYLPKKEFELLFQLASFPGRVYRREELIELVWGF
HHHHHCCCCCEEEEEEEEEEEECCEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
DFEGDERTVDVHIKRLRNRFDHPALTIRTVRGVGYALEVNG
CCCCCCEEHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA