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The map label for this gene is 229916053

Identifier: 229916053

GI number: 229916053

Start: 289275

End: 290723

Strand: Reverse

Name: 229916053

Synonym: EAT1b_0321

Alternate gene names: NA

Gene position: 290723-289275 (Counterclockwise)

Preceding gene: 229916054

Following gene: 229916051

Centisome position: 9.69

GC content: 49.21

Gene sequence:

>1449_bases
ATGAAAAAGATTGCCCTTTTGACAGCGATTGCCCTTTTACTGCCGGTGGGAGTAGATGCTGCAAAGCCAGTCATCCTTAA
GAAACATGGCTACGTCGTTTCAGAACCACAAGTCACGAGTCAATATTATGTGAAGCAAATCGGTACGGATTTGGCCTGGA
GTAAGACGAGAGGCGCAAGTGATATCGTTGTGGCGCTGATTGACTCGTCAGCTGACCGGAACCATACGGATTTGAAGAAC
GTTCCTCGTGTCGTCAATTCCATGAAAGGTCCGTATACTGCGGATATTCATGGTACGCATACCGCCGGAATCATGGCCGG
GAAACATAACCGCTTTGGGATTGCAGGACTCGCGCCGAACGTCCGCTACCACTTCTATAATGTGTTTTACGGGGTGAATA
AAGATAAAACGGACTCTTGGACGGTCGCTAATGCCGTGGATACGGCTGTGGAGAAAGGGGCGAACATCATCAACCTCTCG
CTTGGTGGGGATGATTATGATAGTCGTTTGGCCGCATCAATCAAACGGGCAAGGGCAAAAGGGGTCATTATCGTCGCATC
ATCTGGAAATGATCGAAAACAGACGATTAACTTTCCCGCGAACATGAAAGAAGTAATCGCGGTCGGTGCAATTGATTCTA
GACATCGTCTCGCGAGCTTTAGCAATATGGACGATCGCGTCAAAATCGTGGCGCCAGGTGTGAACATCCTCTCGCTCGGG
GTCAACAACCGCTTTATCTATATGGACGGGACGTCGATGGCGGCACCGATGGTCACGGCGAGTCTCGCGCTCGTCAAATC
GATCAACCCTTATTTGACACCGGGTGAGATTGACCAGTTAATTGCGAAGATGCCTCGAGCGTCCGGCAAGTCCTATACGG
AATTGAATACAATGAAACTATTAGAAGCGACGGCTCGCCCGATTCATATCTCTGCCCCTTCGGTGTGGAAGAGCCGATAC
GTGAATGATGTCAAGTTGAGTGTCATGAACCATTCGAACTTGAAATCTTCGTTCACACTGTATCAAGGGAACAAGAAAAT
TAAGACACTTACTCCAAATCGGTCGTTCACAATGTATTCGAGTGGGGATTGGCTACCGAGCGGACAATACCGCATCGTCG
GTCAAGTAACGGACGGAAAACATAAGCGCTACACGAGCCGAACGATCGATTATGTCAACACATTGAAGACGGCAGTTTCT
GTGAAGGTGTCGGAGGAAGGGACGTTCACGATTCATACGACACGAAAAGGGACGGTCACGGTACTTGATTCAAATGGGAA
GGTCTTATACGAAGCGCTCCACATCGCTGGGACATTCCCGGTAAGAGGGGATACGGCGGAAAAGTTGACTGTCATTCTGA
AGCCGACGGACCTTCGTGAAAAAGTAGTGACGACATCTTATGAGCCACCAATCATTGAAGACGAGCCCCCGGTCACAGAG
ACCTTATAA

Upstream 100 bases:

>100_bases
TGGTGAATTTGTCGACAACTTTTTATTCAAAAAAAGGGAAATCTAATCCAAAGTTTGAGATAATGGAGTCACTTTAACAG
TTTGGAATGGAGCGGAAGGA

Downstream 100 bases:

>100_bases
GACAAAAAGCCGCCTTCTCCTAAGGGAGAGACGGCTTCTTCTATTTAATCGATGGTGATGGCTTCTCCACACCAACGGAT
ACTCGCTTCTAATACGTTAC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKKIALLTAIALLLPVGVDAAKPVILKKHGYVVSEPQVTSQYYVKQIGTDLAWSKTRGASDIVVALIDSSADRNHTDLKN
VPRVVNSMKGPYTADIHGTHTAGIMAGKHNRFGIAGLAPNVRYHFYNVFYGVNKDKTDSWTVANAVDTAVEKGANIINLS
LGGDDYDSRLAASIKRARAKGVIIVASSGNDRKQTINFPANMKEVIAVGAIDSRHRLASFSNMDDRVKIVAPGVNILSLG
VNNRFIYMDGTSMAAPMVTASLALVKSINPYLTPGEIDQLIAKMPRASGKSYTELNTMKLLEATARPIHISAPSVWKSRY
VNDVKLSVMNHSNLKSSFTLYQGNKKIKTLTPNRSFTMYSSGDWLPSGQYRIVGQVTDGKHKRYTSRTIDYVNTLKTAVS
VKVSEEGTFTIHTTRKGTVTVLDSNGKVLYEALHIAGTFPVRGDTAEKLTVILKPTDLREKVVTTSYEPPIIEDEPPVTE
TL

Sequences:

>Translated_482_residues
MKKIALLTAIALLLPVGVDAAKPVILKKHGYVVSEPQVTSQYYVKQIGTDLAWSKTRGASDIVVALIDSSADRNHTDLKN
VPRVVNSMKGPYTADIHGTHTAGIMAGKHNRFGIAGLAPNVRYHFYNVFYGVNKDKTDSWTVANAVDTAVEKGANIINLS
LGGDDYDSRLAASIKRARAKGVIIVASSGNDRKQTINFPANMKEVIAVGAIDSRHRLASFSNMDDRVKIVAPGVNILSLG
VNNRFIYMDGTSMAAPMVTASLALVKSINPYLTPGEIDQLIAKMPRASGKSYTELNTMKLLEATARPIHISAPSVWKSRY
VNDVKLSVMNHSNLKSSFTLYQGNKKIKTLTPNRSFTMYSSGDWLPSGQYRIVGQVTDGKHKRYTSRTIDYVNTLKTAVS
VKVSEEGTFTIHTTRKGTVTVLDSNGKVLYEALHIAGTFPVRGDTAEKLTVILKPTDLREKVVTTSYEPPIIEDEPPVTE
TL
>Mature_482_residues
MKKIALLTAIALLLPVGVDAAKPVILKKHGYVVSEPQVTSQYYVKQIGTDLAWSKTRGASDIVVALIDSSADRNHTDLKN
VPRVVNSMKGPYTADIHGTHTAGIMAGKHNRFGIAGLAPNVRYHFYNVFYGVNKDKTDSWTVANAVDTAVEKGANIINLS
LGGDDYDSRLAASIKRARAKGVIIVASSGNDRKQTINFPANMKEVIAVGAIDSRHRLASFSNMDDRVKIVAPGVNILSLG
VNNRFIYMDGTSMAAPMVTASLALVKSINPYLTPGEIDQLIAKMPRASGKSYTELNTMKLLEATARPIHISAPSVWKSRY
VNDVKLSVMNHSNLKSSFTLYQGNKKIKTLTPNRSFTMYSSGDWLPSGQYRIVGQVTDGKHKRYTSRTIDYVNTLKTAVS
VKVSEEGTFTIHTTRKGTVTVLDSNGKVLYEALHIAGTFPVRGDTAEKLTVILKPTDLREKVVTTSYEPPIIEDEPPVTE
TL

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=277, Percent_Identity=29.2418772563177, Blast_Score=89, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324576, Length=242, Percent_Identity=29.3388429752066, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319893, Length=241, Percent_Identity=29.045643153527, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550681, Length=284, Percent_Identity=26.4084507042254, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 52625; Mature: 52625

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIALLTAIALLLPVGVDAAKPVILKKHGYVVSEPQVTSQYYVKQIGTDLAWSKTRGAS
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
DIVVALIDSSADRNHTDLKNVPRVVNSMKGPYTADIHGTHTAGIMAGKHNRFGIAGLAPN
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCEEEEECCCC
VRYHFYNVFYGVNKDKTDSWTVANAVDTAVEKGANIINLSLGGDDYDSRLAASIKRARAK
CEEEEEEEEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC
GVIIVASSGNDRKQTINFPANMKEVIAVGAIDSRHRLASFSNMDDRVKIVAPGVNILSLG
EEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHCCCCCCEEEEEECCCEEEEEC
VNNRFIYMDGTSMAAPMVTASLALVKSINPYLTPGEIDQLIAKMPRASGKSYTELNTMKL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
LEATARPIHISAPSVWKSRYVNDVKLSVMNHSNLKSSFTLYQGNKKIKTLTPNRSFTMYS
HHHCCCCEEECCCHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCCCEEEEE
SGDWLPSGQYRIVGQVTDGKHKRYTSRTIDYVNTLKTAVSVKVSEEGTFTIHTTRKGTVT
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCEEE
VLDSNGKVLYEALHIAGTFPVRGDTAEKLTVILKPTDLREKVVTTSYEPPIIEDEPPVTE
EEECCCCEEEEEEEHEECCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKKIALLTAIALLLPVGVDAAKPVILKKHGYVVSEPQVTSQYYVKQIGTDLAWSKTRGAS
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
DIVVALIDSSADRNHTDLKNVPRVVNSMKGPYTADIHGTHTAGIMAGKHNRFGIAGLAPN
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCEEEEECCCC
VRYHFYNVFYGVNKDKTDSWTVANAVDTAVEKGANIINLSLGGDDYDSRLAASIKRARAK
CEEEEEEEEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCC
GVIIVASSGNDRKQTINFPANMKEVIAVGAIDSRHRLASFSNMDDRVKIVAPGVNILSLG
EEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCHHHHHCCCCCCEEEEEECCCEEEEEC
VNNRFIYMDGTSMAAPMVTASLALVKSINPYLTPGEIDQLIAKMPRASGKSYTELNTMKL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
LEATARPIHISAPSVWKSRYVNDVKLSVMNHSNLKSSFTLYQGNKKIKTLTPNRSFTMYS
HHHCCCCEEECCCHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCCCEEEEE
SGDWLPSGQYRIVGQVTDGKHKRYTSRTIDYVNTLKTAVSVKVSEEGTFTIHTTRKGTVT
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCEEE
VLDSNGKVLYEALHIAGTFPVRGDTAEKLTVILKPTDLREKVVTTSYEPPIIEDEPPVTE
EEECCCCEEEEEEEHEECCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]