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The map label for this gene is cvrA [H]

Identifier: 229915997

GI number: 229915997

Start: 230981

End: 232201

Strand: Reverse

Name: cvrA [H]

Synonym: EAT1b_0265

Alternate gene names: 229915997

Gene position: 232201-230981 (Counterclockwise)

Preceding gene: 229915999

Following gene: 229915995

Centisome position: 7.74

GC content: 50.86

Gene sequence:

>1221_bases
ATGGAAGACATGATGATCGGCTTCAGCTTACTTGTCCTCATCGGTGCACTTTCGCAGTTACTCGCTTGGCGTTTTGACTT
TCCAGCCATCTTGATCATGACGGTTGCCGGGATTCTCGTCGGACCGATTTTCGGTTGGCTGGAGCCGGATCGGATACTCT
GTGAGCTGTATAGCCCACTCATCTCCATTGCGGTGGCGCTCATCCTATTCGAAGGAAGCCTCAGTCTCGAATTCAGAGAG
ATTGATGATTTACGGAAATCAATCTTTCGACTCGTTACGGTCGGGGTGTTCGTGTCCTTTATCTTGACCTCGATTTTGCT
CATCATGATTGGCGATTTTCATTGGTTGCCAGCATTTACGCTCGGTGCCATCTTCGTCGTGACCGGGCCGACCGTCATCA
TTCCGTTACTAAGGCAAGCCAACTTGTCCGCACGTCCGGCTAAAGTCTTAAAATGGGAAGGAATCATCGTCGATCCGCTT
GGCGCCTTGATGGGATTATTCGTCGTCCGCGTAGGCTTCATTTTCTATCAGAACGATGGACTCGCGAGCCACTTGCCATT
CTTTTGGTCCTGTATCGTCGCCGTCGCCTTTGGGATTGCCGTCGGACATCTATTGATTCGCTTATTCGGGAATGAGAAAG
TCCCAGAATATTTACGGACGACGTTGACGTTCTCCGGAGTCCTTCTTGTCTACTCCATCAGTGAATGGGTCATGAGCGAG
GTTGGGCTATTGGCTGTGACGGCAATGGGATTGACGATGGCGAACTCCAAACATGGACATCTCCACATTTTGAAACAACT
TCGTGAATTTAAAGAAAATATCTCTATCTTACTCGTTTCCACCGTGTTTATCATTTTGACCGCGAGCTTGACGCGCGATA
GTTTGCTCGCCATCTTCGAGTGGCCACTCCTCCTGTCGATTCTCGGGATCTTATTTTTAGTCCGTCCGATCTCGGTACAG
ACGTCGCTCCTCCGTTCCCCGTTATCGATGCAAGAGCGGGCGCTCATCAGCTGGATTGCCCCTCGAGGCATCGTCGCGAT
GACGGTGACCGGTTTCTTTGCACAAGAGATCGCCGAACTCGGGATTGAAGATGCGGAGCGGATGTTGCCGATCACACTCG
GTTTAGTCGTAACGTCTGTCGCCCTGCATGGACTGACGATTAAACCACTTGCCAAGCGACTCGGACTGACGAAAGTGAAG
AATCCATGGGAAAAGGCGTAG

Upstream 100 bases:

>100_bases
CCCTTTCCTTCAATTCTTACCCGAAATCAGACAATCTTAGCAAATGTTTTTCATGATGTGGGTATACATTAATGAAGAAG
TGAAGAAACGGGGGAAGCTT

Downstream 100 bases:

>100_bases
ACAAAAAAAGACACCGCCCGATGGCAGTGTCTTTAATCAGCTTGAATTAGTTCAAGACTTTGATTGTGATTGATTGGCGA
CCGAAAGCAAGTGCTTGCTC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MEDMMIGFSLLVLIGALSQLLAWRFDFPAILIMTVAGILVGPIFGWLEPDRILCELYSPLISIAVALILFEGSLSLEFRE
IDDLRKSIFRLVTVGVFVSFILTSILLIMIGDFHWLPAFTLGAIFVVTGPTVIIPLLRQANLSARPAKVLKWEGIIVDPL
GALMGLFVVRVGFIFYQNDGLASHLPFFWSCIVAVAFGIAVGHLLIRLFGNEKVPEYLRTTLTFSGVLLVYSISEWVMSE
VGLLAVTAMGLTMANSKHGHLHILKQLREFKENISILLVSTVFIILTASLTRDSLLAIFEWPLLLSILGILFLVRPISVQ
TSLLRSPLSMQERALISWIAPRGIVAMTVTGFFAQEIAELGIEDAERMLPITLGLVVTSVALHGLTIKPLAKRLGLTKVK
NPWEKA

Sequences:

>Translated_406_residues
MEDMMIGFSLLVLIGALSQLLAWRFDFPAILIMTVAGILVGPIFGWLEPDRILCELYSPLISIAVALILFEGSLSLEFRE
IDDLRKSIFRLVTVGVFVSFILTSILLIMIGDFHWLPAFTLGAIFVVTGPTVIIPLLRQANLSARPAKVLKWEGIIVDPL
GALMGLFVVRVGFIFYQNDGLASHLPFFWSCIVAVAFGIAVGHLLIRLFGNEKVPEYLRTTLTFSGVLLVYSISEWVMSE
VGLLAVTAMGLTMANSKHGHLHILKQLREFKENISILLVSTVFIILTASLTRDSLLAIFEWPLLLSILGILFLVRPISVQ
TSLLRSPLSMQERALISWIAPRGIVAMTVTGFFAQEIAELGIEDAERMLPITLGLVVTSVALHGLTIKPLAKRLGLTKVK
NPWEKA
>Mature_406_residues
MEDMMIGFSLLVLIGALSQLLAWRFDFPAILIMTVAGILVGPIFGWLEPDRILCELYSPLISIAVALILFEGSLSLEFRE
IDDLRKSIFRLVTVGVFVSFILTSILLIMIGDFHWLPAFTLGAIFVVTGPTVIIPLLRQANLSARPAKVLKWEGIIVDPL
GALMGLFVVRVGFIFYQNDGLASHLPFFWSCIVAVAFGIAVGHLLIRLFGNEKVPEYLRTTLTFSGVLLVYSISEWVMSE
VGLLAVTAMGLTMANSKHGHLHILKQLREFKENISILLVSTVFIILTASLTRDSLLAIFEWPLLLSILGILFLVRPISVQ
TSLLRSPLSMQERALISWIAPRGIVAMTVTGFFAQEIAELGIEDAERMLPITLGLVVTSVALHGLTIKPLAKRLGLTKVK
NPWEKA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 44819; Mature: 44819

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDMMIGFSLLVLIGALSQLLAWRFDFPAILIMTVAGILVGPIFGWLEPDRILCELYSPL
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISIAVALILFEGSLSLEFREIDDLRKSIFRLVTVGVFVSFILTSILLIMIGDFHWLPAFT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGAIFVVTGPTVIIPLLRQANLSARPAKVLKWEGIIVDPLGALMGLFVVRVGFIFYQNDG
HHHHHEECCCHHHHHHHHHCCCCCCCCHHEEECCEEECHHHHHHHHHHHHHHHHHCCCCC
LASHLPFFWSCIVAVAFGIAVGHLLIRLFGNEKVPEYLRTTLTFSGVLLVYSISEWVMSE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLLAVTAMGLTMANSKHGHLHILKQLREFKENISILLVSTVFIILTASLTRDSLLAIFE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WPLLLSILGILFLVRPISVQTSLLRSPLSMQERALISWIAPRGIVAMTVTGFFAQEIAEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GIEDAERMLPITLGLVVTSVALHGLTIKPLAKRLGLTKVKNPWEKA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCCC
>Mature Secondary Structure
MEDMMIGFSLLVLIGALSQLLAWRFDFPAILIMTVAGILVGPIFGWLEPDRILCELYSPL
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ISIAVALILFEGSLSLEFREIDDLRKSIFRLVTVGVFVSFILTSILLIMIGDFHWLPAFT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGAIFVVTGPTVIIPLLRQANLSARPAKVLKWEGIIVDPLGALMGLFVVRVGFIFYQNDG
HHHHHEECCCHHHHHHHHHCCCCCCCCHHEEECCEEECHHHHHHHHHHHHHHHHHCCCCC
LASHLPFFWSCIVAVAFGIAVGHLLIRLFGNEKVPEYLRTTLTFSGVLLVYSISEWVMSE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLLAVTAMGLTMANSKHGHLHILKQLREFKENISILLVSTVFIILTASLTRDSLLAIFE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WPLLLSILGILFLVRPISVQTSLLRSPLSMQERALISWIAPRGIVAMTVTGFFAQEIAEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GIEDAERMLPITLGLVVTSVALHGLTIKPLAKRLGLTKVKNPWEKA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]