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The map label for this gene is nhaK [H]

Identifier: 229915955

GI number: 229915955

Start: 193685

End: 194890

Strand: Reverse

Name: nhaK [H]

Synonym: EAT1b_0223

Alternate gene names: 229915955

Gene position: 194890-193685 (Counterclockwise)

Preceding gene: 229915959

Following gene: 229915954

Centisome position: 6.5

GC content: 46.19

Gene sequence:

>1206_bases
ATGATCGCGCAACAAATCATCACATTGCTACTGATTGGCTATCTCATTTATTTGATTGATTCAAAACGAAATTACTTCCC
TGTCCCGGTCATCTTGGTCTTGATTGGGATTGGTCTCTCATATATCGCCTTTTTTGATTCAGTATTCATTTCAAAAGATA
TGATCTTCGAGGTGTTCCTACCGGCACTTCTGTTTACATCCGCTTATCAGTTCAAATACAAAGATTTGAAAGACAATATC
GGGATCATCACGATATTGAGTACGGTTGGTCTTGTCTTGACCGCCATCCTAATGGGGTATGGCACGTTTTGGATCAGCGA
GCTCTTCACCCCGCTCAGCCTGACCGCCTCTTTCTTATTGGCATCCATCTTGATTCCGACCGACCCCGTTTCCGTGTCGG
CGATTTTAAAGCGGAGTAAAGGTGAGAAGCGGATTGCGGATGTTGTCGAAGGTGAATCGATGGTGAACGATGGGACGAGT
GTCGTCATCTTCACGATCTTCCTCAGTATGTTCGCGACAGGAGAACAGTTCTCCACGCTCAGCTTTTTAACTGAATTTTT
GATTGTTTCAGCCGGAGGAATCGGCATCGGCTTCATCGTCGGATTATTACTTAAAAAATTGATGATTGTCAGCTTTAAAA
AGCATGAGCTCGTCATGTTGACGATCGTCATCGCATACGGAGCATTTTATCTCGCCGACGCGCTAGAAGTATCGGGTGTC
CTTGCGACCGTCACAGCCGGCATGATGCTTTCTCATGAGCTCGGCATGAAAGAGGACTACGAATCGGTCCAGCGACACTT
GAATGGATTTTGGGACATCGTCATTCCGATATTGCTCGCTCTCCTGTTCTTATTGATTGGAATCGAGGCGACCAGCTATT
TGTCTGTATCGCTCTGGACGTTCGCTGTTCTTTTATTCCTACTTTCGCTTCTGACCCGGTTCATCGTCGTCGGCGGTCTC
GTTTATACCGTTCCTGTGTGGCGTAGAGAATTTAAAGACGATTTGACAGCGACTTCGCTCCTTACTTGGTCCGGGATTAA
AGGAACGATGTCGATTGCCCTCGTCCTCTGGCTAGAGGCAGAGAACATTAACGGCTCGAGCGAAATGATATCTCTCGCGT
TTGCCGTCATTTTACTCTCTCTGATCTTACAAAGCATCGGTGTCTACCCATTAACGACCTATTTAACGAATAAACATGAC
GAGTGA

Upstream 100 bases:

>100_bases
AAATGAATGTACTATCCCCTATATTCCACAATTCTCGTTTGATTAGACCTTGAATGGGAAGATAGTGTATAGCAACTTGA
TTGCAGAGGAGGACGTCGTC

Downstream 100 bases:

>100_bases
CGGAACCCTTCCTCAGAGAAGGGTTTTTTACATTCTGAAATTGACATCGCCCACTTTTAGTGTAAAATTACACTTGTAAT
ATACTAGGAGGTGATTCGTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIAQQIITLLLIGYLIYLIDSKRNYFPVPVILVLIGIGLSYIAFFDSVFISKDMIFEVFLPALLFTSAYQFKYKDLKDNI
GIITILSTVGLVLTAILMGYGTFWISELFTPLSLTASFLLASILIPTDPVSVSAILKRSKGEKRIADVVEGESMVNDGTS
VVIFTIFLSMFATGEQFSTLSFLTEFLIVSAGGIGIGFIVGLLLKKLMIVSFKKHELVMLTIVIAYGAFYLADALEVSGV
LATVTAGMMLSHELGMKEDYESVQRHLNGFWDIVIPILLALLFLLIGIEATSYLSVSLWTFAVLLFLLSLLTRFIVVGGL
VYTVPVWRREFKDDLTATSLLTWSGIKGTMSIALVLWLEAENINGSSEMISLAFAVILLSLILQSIGVYPLTTYLTNKHD
E

Sequences:

>Translated_401_residues
MIAQQIITLLLIGYLIYLIDSKRNYFPVPVILVLIGIGLSYIAFFDSVFISKDMIFEVFLPALLFTSAYQFKYKDLKDNI
GIITILSTVGLVLTAILMGYGTFWISELFTPLSLTASFLLASILIPTDPVSVSAILKRSKGEKRIADVVEGESMVNDGTS
VVIFTIFLSMFATGEQFSTLSFLTEFLIVSAGGIGIGFIVGLLLKKLMIVSFKKHELVMLTIVIAYGAFYLADALEVSGV
LATVTAGMMLSHELGMKEDYESVQRHLNGFWDIVIPILLALLFLLIGIEATSYLSVSLWTFAVLLFLLSLLTRFIVVGGL
VYTVPVWRREFKDDLTATSLLTWSGIKGTMSIALVLWLEAENINGSSEMISLAFAVILLSLILQSIGVYPLTTYLTNKHD
E
>Mature_401_residues
MIAQQIITLLLIGYLIYLIDSKRNYFPVPVILVLIGIGLSYIAFFDSVFISKDMIFEVFLPALLFTSAYQFKYKDLKDNI
GIITILSTVGLVLTAILMGYGTFWISELFTPLSLTASFLLASILIPTDPVSVSAILKRSKGEKRIADVVEGESMVNDGTS
VVIFTIFLSMFATGEQFSTLSFLTEFLIVSAGGIGIGFIVGLLLKKLMIVSFKKHELVMLTIVIAYGAFYLADALEVSGV
LATVTAGMMLSHELGMKEDYESVQRHLNGFWDIVIPILLALLFLLIGIEATSYLSVSLWTFAVLLFLLSLLTRFIVVGGL
VYTVPVWRREFKDDLTATSLLTWSGIKGTMSIALVLWLEAENINGSSEMISLAFAVILLSLILQSIGVYPLTTYLTNKHD
E

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=378, Percent_Identity=23.5449735449735, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI15529998, Length=398, Percent_Identity=22.3618090452261, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI194239733, Length=357, Percent_Identity=24.0896358543417, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI148727259, Length=360, Percent_Identity=21.3888888888889, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790501, Length=389, Percent_Identity=25.4498714652956, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=390, Percent_Identity=24.6153846153846, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71980847, Length=373, Percent_Identity=24.1286863270777, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=323, Percent_Identity=24.4582043343653, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=323, Percent_Identity=24.4582043343653, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993590, Length=329, Percent_Identity=24.6200607902736, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993582, Length=364, Percent_Identity=26.3736263736264, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71999819, Length=390, Percent_Identity=23.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=390, Percent_Identity=23.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999821, Length=387, Percent_Identity=23.5142118863049, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=395, Percent_Identity=24.3037974683544, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320663, Length=215, Percent_Identity=25.1162790697674, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510740, Length=367, Percent_Identity=24.7956403269755, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221510736, Length=367, Percent_Identity=24.7956403269755, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221510732, Length=367, Percent_Identity=24.7956403269755, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585580, Length=367, Percent_Identity=24.7956403269755, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585578, Length=367, Percent_Identity=24.7956403269755, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360447, Length=423, Percent_Identity=24.822695035461, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221473212, Length=327, Percent_Identity=26.2996941896024, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281364513, Length=327, Percent_Identity=26.2996941896024, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221473222, Length=329, Percent_Identity=26.1398176291793, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221473215, Length=329, Percent_Identity=26.1398176291793, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221510734, Length=367, Percent_Identity=24.2506811989101, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221510738, Length=367, Percent_Identity=24.2506811989101, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44222; Mature: 44222

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQQIITLLLIGYLIYLIDSKRNYFPVPVILVLIGIGLSYIAFFDSVFISKDMIFEVFL
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALLFTSAYQFKYKDLKDNIGIITILSTVGLVLTAILMGYGTFWISELFTPLSLTASFLL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASILIPTDPVSVSAILKRSKGEKRIADVVEGESMVNDGTSVVIFTIFLSMFATGEQFSTL
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHH
SFLTEFLIVSAGGIGIGFIVGLLLKKLMIVSFKKHELVMLTIVIAYGAFYLADALEVSGV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LATVTAGMMLSHELGMKEDYESVQRHLNGFWDIVIPILLALLFLLIGIEATSYLSVSLWT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FAVLLFLLSLLTRFIVVGGLVYTVPVWRREFKDDLTATSLLTWSGIKGTMSIALVLWLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEE
ENINGSSEMISLAFAVILLSLILQSIGVYPLTTYLTNKHDE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MIAQQIITLLLIGYLIYLIDSKRNYFPVPVILVLIGIGLSYIAFFDSVFISKDMIFEVFL
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALLFTSAYQFKYKDLKDNIGIITILSTVGLVLTAILMGYGTFWISELFTPLSLTASFLL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASILIPTDPVSVSAILKRSKGEKRIADVVEGESMVNDGTSVVIFTIFLSMFATGEQFSTL
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHH
SFLTEFLIVSAGGIGIGFIVGLLLKKLMIVSFKKHELVMLTIVIAYGAFYLADALEVSGV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LATVTAGMMLSHELGMKEDYESVQRHLNGFWDIVIPILLALLFLLIGIEATSYLSVSLWT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FAVLLFLLSLLTRFIVVGGLVYTVPVWRREFKDDLTATSLLTWSGIKGTMSIALVLWLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEE
ENINGSSEMISLAFAVILLSLILQSIGVYPLTTYLTNKHDE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA