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The map label for this gene is lysC [H]

Identifier: 229587112

GI number: 229587112

Start: 1076721

End: 1077926

Strand: Direct

Name: lysC [H]

Synonym: RAF_ORF1059

Alternate gene names: 229587112

Gene position: 1076721-1077926 (Clockwise)

Preceding gene: 229587111

Following gene: 229587113

Centisome position: 84.21

GC content: 30.27

Gene sequence:

>1206_bases
ATGGCCTTAATAATTCAAAAATTCGGTGGCACTTCCGTTGCAAATATTGATAGAATAAAAAAAATCGTTCCTATCATAAA
AACCGAAATAGCTAAAAATAACCAAATAATTGTAGTAGTTTCGGCTATGGCAGGTGTTACTAATCAACTTGTCACATTGT
GTAATGAAGTATCAAGCCTTAATAACATTTCTCAATTTGCAGAATATGATGTAGCACTTTCTAGCGGTGAAATAGTCACT
GCTTCATTACTAGCGCTCGCTCTTCAAGAAGAAGATATAAAGGCGCGATCATTTCTAGCTTGGCAATTACCGATGCTCAC
CGATAATAATCATAGTAAAGCTTTAGTAGAATCAATTACTACAGATTTACTAGAAAAATATTTACAGTTAAATACCATCC
CTATAATAGCCGGTTTTCAAGGAATTAACAAATCCAATAGGTTAACTACTTTGGGCAGAGGAGGATCTGATACTACTGCC
GCCTTAATCGCTGCAGCTATGAAAGCCGATAGATGTGATATTTATACCGATGTAGAGGGAATATTTACTGCTGATCCAAG
AATTATTCCAAATGCCAAGAAGATAAAAGAAATAGATTTTTTAGAAATGTTAGAACTAGCATCAAGTGGAGCAAAAGTAC
TACACCCTAGAGCCGGAGAGTTAGTAATGCGGTATAAAATAGATATGCGTGTTCTGTCAACATTTTCACCGGATACAGAA
GGTACGTTAATCACTTCAAAGGATAAAAATATGGAGAATGGGATTATTAACAGCATTACTTCTAATAAAAATTTATTAAA
AATATCTGTAAAGAGCATTTCTTTAAGTTTTTTGCAAGTTGCAAATATGATTACACAAAATAATAATCATATTGAGTTTA
TGCAAGAGATAAAAAATAATGAAGAATATAGTTTTATTACAAATTTAACCGATAAAAATAATTTACAAGCTTTACTGACT
AATTTAAAAGATGATAAGCAGATACAAGATTTTACTTTTGATACCGAAATTGCTACAATCTCTCTTATTGGTTATGGGAT
TAAAAATGATTGTAAATTACTTGAAACGATATTATCAAAGTTAACGAACGATAATATAAATGTTCACATGATACAATTAT
CAGAAGTTAAAATTACCTTATTCATAAATGATCAAGATACAGAAAAAACAATTTTTAATTTATATAATCTTTTTAAAATA
TCTTAG

Upstream 100 bases:

>100_bases
GACAATTGACAACCGTTCCACACAATAATGTCTGTAAGTGCGCTAGATGACGACAGGCGGAAATTAATTATATAACATAA
TATTCTATTAGGCTTTATTT

Downstream 100 bases:

>100_bases
ATTCTGCATCTGAAATTTAATTTATAGAAAAAGAAATGGAACAGACATGGCTCATAATACTACAGAAAAATTTTATAATT
TGTGACAAAAAAAGTTAAAA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALIIQKFGGTSVANIDRIKKIVPIIKTEIAKNNQIIVVVSAMAGVTNQLVTLCNEVSSLNNISQFAEYDVALSSGEIVT
ASLLALALQEEDIKARSFLAWQLPMLTDNNHSKALVESITTDLLEKYLQLNTIPIIAGFQGINKSNRLTTLGRGGSDTTA
ALIAAAMKADRCDIYTDVEGIFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAGELVMRYKIDMRVLSTFSPDTE
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNNEEYSFITNLTDKNNLQALLT
NLKDDKQIQDFTFDTEIATISLIGYGIKNDCKLLETILSKLTNDNINVHMIQLSEVKITLFINDQDTEKTIFNLYNLFKI
S

Sequences:

>Translated_401_residues
MALIIQKFGGTSVANIDRIKKIVPIIKTEIAKNNQIIVVVSAMAGVTNQLVTLCNEVSSLNNISQFAEYDVALSSGEIVT
ASLLALALQEEDIKARSFLAWQLPMLTDNNHSKALVESITTDLLEKYLQLNTIPIIAGFQGINKSNRLTTLGRGGSDTTA
ALIAAAMKADRCDIYTDVEGIFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAGELVMRYKIDMRVLSTFSPDTE
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNNEEYSFITNLTDKNNLQALLT
NLKDDKQIQDFTFDTEIATISLIGYGIKNDCKLLETILSKLTNDNINVHMIQLSEVKITLFINDQDTEKTIFNLYNLFKI
S
>Mature_400_residues
ALIIQKFGGTSVANIDRIKKIVPIIKTEIAKNNQIIVVVSAMAGVTNQLVTLCNEVSSLNNISQFAEYDVALSSGEIVTA
SLLALALQEEDIKARSFLAWQLPMLTDNNHSKALVESITTDLLEKYLQLNTIPIIAGFQGINKSNRLTTLGRGGSDTTAA
LIAAAMKADRCDIYTDVEGIFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAGELVMRYKIDMRVLSTFSPDTEG
TLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNNEEYSFITNLTDKNNLQALLTN
LKDDKQIQDFTFDTEIATISLIGYGIKNDCKLLETILSKLTNDNINVHMIQLSEVKITLFINDQDTEKTIFNLYNLFKIS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartokinase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=461, Percent_Identity=26.6811279826464, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790455, Length=459, Percent_Identity=28.5403050108932, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1790376, Length=387, Percent_Identity=23.2558139534884, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=481, Percent_Identity=23.7006237006237, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR001057 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44518; Mature: 44387

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIIQKFGGTSVANIDRIKKIVPIIKTEIAKNNQIIVVVSAMAGVTNQLVTLCNEVSSL
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
NNISQFAEYDVALSSGEIVTASLLALALQEEDIKARSFLAWQLPMLTDNNHSKALVESIT
HHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHEEEEECCEEECCCCHHHHHHHHH
TDLLEKYLQLNTIPIIAGFQGINKSNRLTTLGRGGSDTTAALIAAAMKADRCDIYTDVEG
HHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCE
IFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAGELVMRYKIDMRVLSTFSPDTE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEECCCCCCC
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNN
CCEEEECCCCCCCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
EEYSFITNLTDKNNLQALLTNLKDDKQIQDFTFDTEIATISLIGYGIKNDCKLLETILSK
CCEEEEECCCCCCHHHHHHHCCCCCCCHHCEEECCCEEEEEEEECCCCCHHHHHHHHHHH
LTNDNINVHMIQLSEVKITLFINDQDTEKTIFNLYNLFKIS
HCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALIIQKFGGTSVANIDRIKKIVPIIKTEIAKNNQIIVVVSAMAGVTNQLVTLCNEVSSL
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHH
NNISQFAEYDVALSSGEIVTASLLALALQEEDIKARSFLAWQLPMLTDNNHSKALVESIT
HHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCHHHEEEEECCEEECCCCHHHHHHHHH
TDLLEKYLQLNTIPIIAGFQGINKSNRLTTLGRGGSDTTAALIAAAMKADRCDIYTDVEG
HHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCE
IFTADPRIIPNAKKIKEIDFLEMLELASSGAKVLHPRAGELVMRYKIDMRVLSTFSPDTE
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEECCCCCCC
GTLITSKDKNMENGIINSITSNKNLLKISVKSISLSFLQVANMITQNNNHIEFMQEIKNN
CCEEEECCCCCCCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
EEYSFITNLTDKNNLQALLTNLKDDKQIQDFTFDTEIATISLIGYGIKNDCKLLETILSK
CCEEEEECCCCCCHHHHHHHCCCCCCCHHCEEECCCEEEEEEEECCCCCHHHHHHHHHHH
LTNDNINVHMIQLSEVKITLFINDQDTEKTIFNLYNLFKIS
HCCCCCEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]