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The map label for this gene is nrdA [H]

Identifier: 229586744

GI number: 229586744

Start: 626965

End: 628788

Strand: Direct

Name: nrdA [H]

Synonym: RAF_ORF0596

Alternate gene names: 229586744

Gene position: 626965-628788 (Clockwise)

Preceding gene: 229586743

Following gene: 229586745

Centisome position: 49.04

GC content: 36.02

Gene sequence:

>1824_bases
ATGAACACGTTTAAAAAAAATAAATTTCAAATCACTATAAACAACAACCATAACAATTTACTTACTCCTTTCGGTAAAGC
TATTCTGCGAGATCGGTATCTTATGCAAGGTGAGGATTTTCAAGATTTATTTGCAAGAGTTTCTAGTTATTATGCCGAAA
ATAAACAGCATGCTCAGAAGTTATATGAATATATGAGTAAAATGTGGTTTATGCCAGCAACACCAATCTTAAGTAACGGC
GGGACGGATAGGGGACTTCCTATTTCATGCTTCTTGAATGAGACCGATGATAGCTTAGACGATATAGTAAATTTATGGAC
AGAAAATGTTTGGCTTGCTGCACGCGGTGGCGGGATTGGCAGTTATTGGGGTAATGTTCGTGCTATTAATGAAGGGATTC
GTGATAAAGGTCATTCATCTGGTATTATACCGTTTATTAAAGTAATGGATTCTATGACTCTTGCTATTTCGCAAGGTTCT
ATTAGACGAGGTTCATCGGCTGTATATTTGCCTATTAATCACCCTGAAATTGAAGAATTTATCGATATAAGACGTCCTAC
AGGTGGGGATGTTAACCGTAAAGCTCTTAATATTCATCACGGTATAGCTATAACCGATGAATTTATGAAAGCAGTTGAAA
ACAATACGGATTTTGACCTTGTTAGTCCTGCTACCAAAAAAGTCGTAAATAAAGTTAGAGCAAGAGATTTATGGGTTAAG
TTATTAACTACTAGAATAGAAACAGGTGAGCCTTACTTGTTATTTATCGATAGTGTTAATAAATCTATCCCTGAGCATCA
TAAAAAATTAGGGCTTCAAGTTAAAATGTCTAATCTTTGTAGCGAAATTACATTGCCGACAGGAATTGACCATCTAGGCA
AGTCAAGAACTGCTGTTTGCTGCCTTTCCTCTTTAAATTTAGAGTATTACGAAGAGTGGAAAGACGATAAAGAATTTATC
CATTCTATTATGTTGTTCCTTGATAATGTTTTAGAAGACTTTATTAATAAAGCACCGGATACTATGGCAAGAGCTAAATA
TTCGGCTTTACGTGAGCGCAGCGTTGGACTTGGCGTAATGGGCTTCCACTCATTTTTGCAAATGAAAAAAGTACCGATAG
AATCGGTGATGGCAAAAGTTTGGAATAAAAAAATATTTGAATATATATCTGCTGAAACTGATAAAGCCTCAATAGAAATC
GGTAAAGAAAAAGGAGCATGTCCTGATGCTCTAGATGCAGGAAGTAATGAACGATTTAGCAATAAAACCGCAATAGCACC
TACCGCCTCAATTTCGGTAATAGCAGGTAATGCCTCACCCGGAATAGAGCCGTTTGCCGCTAATAGCTTTGTACAAAAGA
CTTTAACCGGTTCTTTTAACGTGCGTAACAAACATTTAGAAAAGTTATTAGAGGAGAAAGGATTTAATAATGATCAAGTT
TGGTCTTCGATTGCAACACATGAAGGATCAGTACAACATTTAACATTTTTATCCGAAGAAGAAAAACAGGTTTTCAAAAC
CGCTTACGAAATTGATCAGAATTGGCTAATTGAACTGGCAAGCGATCGTATTCCTTACATTACGCAAGCACAATCTTTAA
ACATCTTTTTACCGGGGAATGTTAGTAAGAAATATTTAAATAATATTCATTTTAAAGCCTGGACAAAAGGGGTAAAAAGT
TTATATTACTGTAGATCGACATCAATACAGCGAGCCGATAAGGTCTCGCATGACGTATTAAAGGCCGATTTTAAAGATTT
AGAGGAACAAAACGATAAGTTAGCAGAAGCCGGTAACTACGAAGAATGCTTAGCTTGTCAGTAA

Upstream 100 bases:

>100_bases
TTATTCTCGTGTCTACTTAAGTGAAGATTCTATACACTGAATATGGTGTCATTTTTTCAAAATAAGCATTATAAATCCTA
CAACCCCATTAGTACCTATA

Downstream 100 bases:

>100_bases
GTATAACTATGCAAAGATATTTAGACCCAACAAATGATGTAGCATTTAAAAAATTGTTTACGGATAAAACAAGGTGACTA
GGCTTTCTCAATATATTATG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MNTFKKNKFQITINNNHNNLLTPFGKAILRDRYLMQGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG
GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRAINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS
IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLVSPATKKVVNKVRARDLWVK
LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLSSLNLEYYEEWKDDKEFI
HSIMLFLDNVLEDFINKAPDTMARAKYSALRERSVGLGVMGFHSFLQMKKVPIESVMAKVWNKKIFEYISAETDKASIEI
GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV
WSSIATHEGSVQHLTFLSEEEKQVFKTAYEIDQNWLIELASDRIPYITQAQSLNIFLPGNVSKKYLNNIHFKAWTKGVKS
LYYCRSTSIQRADKVSHDVLKADFKDLEEQNDKLAEAGNYEECLACQ

Sequences:

>Translated_607_residues
MNTFKKNKFQITINNNHNNLLTPFGKAILRDRYLMQGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG
GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRAINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS
IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLVSPATKKVVNKVRARDLWVK
LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLSSLNLEYYEEWKDDKEFI
HSIMLFLDNVLEDFINKAPDTMARAKYSALRERSVGLGVMGFHSFLQMKKVPIESVMAKVWNKKIFEYISAETDKASIEI
GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV
WSSIATHEGSVQHLTFLSEEEKQVFKTAYEIDQNWLIELASDRIPYITQAQSLNIFLPGNVSKKYLNNIHFKAWTKGVKS
LYYCRSTSIQRADKVSHDVLKADFKDLEEQNDKLAEAGNYEECLACQ
>Mature_607_residues
MNTFKKNKFQITINNNHNNLLTPFGKAILRDRYLMQGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG
GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRAINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS
IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLVSPATKKVVNKVRARDLWVK
LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLSSLNLEYYEEWKDDKEFI
HSIMLFLDNVLEDFINKAPDTMARAKYSALRERSVGLGVMGFHSFLQMKKVPIESVMAKVWNKKIFEYISAETDKASIEI
GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV
WSSIATHEGSVQHLTFLSEEEKQVFKTAYEIDQNWLIELASDRIPYITQAQSLNIFLPGNVSKKYLNNIHFKAWTKGVKS
LYYCRSTSIQRADKVSHDVLKADFKDLEEQNDKLAEAGNYEECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=612, Percent_Identity=30.8823529411765, Blast_Score=250, Evalue=3e-66,
Organism=Escherichia coli, GI1789030, Length=593, Percent_Identity=25.4637436762226, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI2367133, Length=468, Percent_Identity=26.7094017094017, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17555242, Length=651, Percent_Identity=29.9539170506912, Blast_Score=239, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322123, Length=632, Percent_Identity=29.9050632911392, Blast_Score=237, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6320914, Length=646, Percent_Identity=28.9473684210526, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI17352481, Length=614, Percent_Identity=29.4788273615635, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 68457; Mature: 68457

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFKKNKFQITINNNHNNLLTPFGKAILRDRYLMQGEDFQDLFARVSSYYAENKQHAQK
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
LYEYMSKMWFMPATPILSNGGTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIG
HHHHHHHHCCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCH
SYWGNVRAINEGIRDKGHSSGIIPFIKVMDSMTLAISQGSIRRGSSAVYLPINHPEIEEF
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEECCCCCHHHH
IDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLVSPATKKVVNKVRARDLWVK
HHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHH
LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVC
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCEEEHHHHHHHCCCCCCHHHHCCCCHHHH
CLSSLNLEYYEEWKDDKEFIHSIMLFLDNVLEDFINKAPDTMARAKYSALRERSVGLGVM
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
GFHSFLQMKKVPIESVMAKVWNKKIFEYISAETDKASIEIGKEKGACPDALDAGSNERFS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHCCCCCCCCC
NKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV
CCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHH
WSSIATHEGSVQHLTFLSEEEKQVFKTAYEIDQNWLIELASDRIPYITQAQSLNIFLPGN
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCEEEEEECCC
VSKKYLNNIHFKAWTKGVKSLYYCRSTSIQRADKVSHDVLKADFKDLEEQNDKLAEAGNY
CCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EECLACQ
HHHHCCC
>Mature Secondary Structure
MNTFKKNKFQITINNNHNNLLTPFGKAILRDRYLMQGEDFQDLFARVSSYYAENKQHAQK
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
LYEYMSKMWFMPATPILSNGGTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIG
HHHHHHHHCCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCH
SYWGNVRAINEGIRDKGHSSGIIPFIKVMDSMTLAISQGSIRRGSSAVYLPINHPEIEEF
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEECCCCCHHHH
IDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLVSPATKKVVNKVRARDLWVK
HHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHH
LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVC
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCEEEHHHHHHHCCCCCCHHHHCCCCHHHH
CLSSLNLEYYEEWKDDKEFIHSIMLFLDNVLEDFINKAPDTMARAKYSALRERSVGLGVM
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
GFHSFLQMKKVPIESVMAKVWNKKIFEYISAETDKASIEIGKEKGACPDALDAGSNERFS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHCCCCCCCCC
NKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV
CCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHH
WSSIATHEGSVQHLTFLSEEEKQVFKTAYEIDQNWLIELASDRIPYITQAQSLNIFLPGN
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCEEEEEECCC
VSKKYLNNIHFKAWTKGVKSLYYCRSTSIQRADKVSHDVLKADFKDLEEQNDKLAEAGNY
CCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EECLACQ
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]