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The map label for this gene is icd [H]

Identifier: 229586515

GI number: 229586515

Start: 357633

End: 359084

Strand: Direct

Name: icd [H]

Synonym: RAF_ORF0327

Alternate gene names: 229586515

Gene position: 357633-359084 (Clockwise)

Preceding gene: 229586514

Following gene: 229586516

Centisome position: 27.97

GC content: 36.09

Gene sequence:

>1452_bases
ATGGCAGAATTTACACCGATTACAATTGCATACGGGGACGGTATAGGTCCTGAAATAATGGAGGCAGTGCTTTATATATT
ACGTAAAGCCGAGGCTCGTATTTGTTTAGAAACCATTGAAGTAGGTGAAAAGCTTTACAAGAAGCATTATACTTCAGGCA
TAAGCGAGGAAAGCTGGGAATCAATACAACGCACCGGTATTATACTTAAAGCCCCGATTACTACTCCGCAAGGTGGAGGA
TATAAAAGTTTAAATGTCACGATTCGTAAAACATTACAGCTTTTTGCTAATATTCGTCCTGTCGTTTCGTTTCATCCTTT
TACTAGAACATTACATCCAAATTTGAACCTAACTATTATACGTGAGAATGAGGAAGATTTATACGCAGGTATAGAATACC
GTCAAACGCATAATATGTATGAGTCAATGAAGTTGATAAGTCATACAGGATGTGAGAAGATTATTAGATATGCTTTTGAA
TATGCAGTAAAAAATAACCGTAAAAAAGTCATGTGTTTAAGCAAAGATAATATTATGAAATTTTCCGATGGGATTTTGCA
TAAAGTATTTAATGAGATTGCAAAAGAATACCCGCAAATTAATAACGCGCATTATATTATCGATATTGGGACGGCAAGGC
TTGCTACCAAACCGGAAATATTTGACGTTATCGTAACTTCTAATTTATACGGTGATATCATATCTGACGTAGCTGCTGAA
ATTTCAGGCTCGGTAGGTCTTGCAGGTTCTGCAAATATTGGGCAGCATTATGCGATGTTTGAAGCGGTACATGGAAGTGC
TCCCGATATTGCCGGTAAAGATATCGCAAATCCTTCAGGGCTTTTAAATGCTGCAATAATGATGCTAGTACATATAGGGC
AGGGTGATATCGCTACATTAATCGAAAATGCTTGGAAAAAAACTATAGAGGATGGCGTTCATACAGCCGATATATATAAC
GAGCAGAGTTCTAGTAAAAAAGTCGGTACAAAAGAATTTGCCGCAGAAGTAACGAAAAGATTAGGACAGTTACCGACAAA
GCTACCTAAAGCAGATTATCCCTTAATTGCTGAGAAGCAAGAAAGTAATATAGATTATAAAATTGATACTAAAGAAGTTA
AGAAATTGGTTGGTACGGATATATTTGTGAATATGAATGTATCTTCCGCTCATGATATAGCAGATAAAATTAATAAACTT
GATCTTGGTAATTTTGAGTTAAAAACAATCTCGTCAAAAGGATTAAAGCTGTGGCCTCGTGATACAAGGTTTGAAACTGT
TTCCGATCATTGGTGTTGTCGTTTTATGAATAAAGACGGCACAGAAATAAAGCATTTAGATATAACAAGATTGCTTGAAG
CTTTAAGCACAGCAAATATCGATTTTATCAAAGTAGAGAATCTGTTTGAATTTGACGGGGTTGCAGGTTATAGCTTGGCT
CAAGGTGAGTAA

Upstream 100 bases:

>100_bases
CATATTTGATAAAATAAATCTATAAAAACTAGTTTTTATAGATTTTACTGGATTCCCGCCTACGCGGGAATGATATAAAC
AAGAGAGTATTTAATTGAAT

Downstream 100 bases:

>100_bases
AAACGTCATTGCGAGTGAACTTTAGTTCGTGAGGCAATCTCAGGACTTGTGCATGAGATTGCTTCGTCAATTATTTCATA
ATTTCCTCGCAATGATGAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARICLETIEVGEKLYKKHYTSGISEESWESIQRTGIILKAPITTPQGGG
YKSLNVTIRKTLQLFANIRPVVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFE
YAVKNNRKKVMCLSKDNIMKFSDGILHKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAE
ISGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYN
EQSSSKKVGTKEFAAEVTKRLGQLPTKLPKADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNMNVSSAHDIADKINKL
DLGNFELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSTANIDFIKVENLFEFDGVAGYSLA
QGE

Sequences:

>Translated_483_residues
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARICLETIEVGEKLYKKHYTSGISEESWESIQRTGIILKAPITTPQGGG
YKSLNVTIRKTLQLFANIRPVVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFE
YAVKNNRKKVMCLSKDNIMKFSDGILHKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAE
ISGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYN
EQSSSKKVGTKEFAAEVTKRLGQLPTKLPKADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNMNVSSAHDIADKINKL
DLGNFELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSTANIDFIKVENLFEFDGVAGYSLA
QGE
>Mature_482_residues
AEFTPITIAYGDGIGPEIMEAVLYILRKAEARICLETIEVGEKLYKKHYTSGISEESWESIQRTGIILKAPITTPQGGGY
KSLNVTIRKTLQLFANIRPVVSFHPFTRTLHPNLNLTIIRENEEDLYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFEY
AVKNNRKKVMCLSKDNIMKFSDGILHKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEI
SGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHTADIYNE
QSSSKKVGTKEFAAEVTKRLGQLPTKLPKADYPLIAEKQESNIDYKIDTKEVKKLVGTDIFVNMNVSSAHDIADKINKLD
LGNFELKTISSKGLKLWPRDTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSTANIDFIKVENLFEFDGVAGYSLAQ
GE

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=343, Percent_Identity=39.3586005830904, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI4758582, Length=330, Percent_Identity=35.4545454545455, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI28178838, Length=312, Percent_Identity=35.8974358974359, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI28178821, Length=311, Percent_Identity=34.0836012861736, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI28178816, Length=311, Percent_Identity=34.0836012861736, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI28178819, Length=166, Percent_Identity=36.7469879518072, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1787381, Length=383, Percent_Identity=31.0704960835509, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788101, Length=304, Percent_Identity=32.2368421052632, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081683, Length=336, Percent_Identity=31.8452380952381, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71986051, Length=339, Percent_Identity=38.3480825958702, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17505779, Length=320, Percent_Identity=37.1875, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25144293, Length=330, Percent_Identity=36.3636363636364, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17550882, Length=339, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324709, Length=335, Percent_Identity=41.7910447761194, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6324291, Length=348, Percent_Identity=35.9195402298851, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=265, Percent_Identity=35.4716981132075, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319830, Length=367, Percent_Identity=26.158038147139, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643270, Length=336, Percent_Identity=39.2857142857143, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24643268, Length=336, Percent_Identity=39.2857142857143, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24661184, Length=319, Percent_Identity=40.4388714733542, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI161078635, Length=327, Percent_Identity=37.6146788990826, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI161078633, Length=327, Percent_Identity=37.6146788990826, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24650122, Length=327, Percent_Identity=37.6146788990826, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161078637, Length=327, Percent_Identity=37.6146788990826, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161078639, Length=322, Percent_Identity=37.888198757764, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI281362242, Length=329, Percent_Identity=32.5227963525836, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24648872, Length=329, Percent_Identity=32.5227963525836, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI20130355, Length=326, Percent_Identity=26.3803680981595, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45550436, Length=216, Percent_Identity=24.0740740740741, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53901; Mature: 53770

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFTPITIAYGDGIGPEIMEAVLYILRKAEARICLETIEVGEKLYKKHYTSGISEESWE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIQRTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPVVSFHPFTRTLHPNLNLTII
HHHHCCCEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHEEECCCCEEECCCCEEEEE
RENEEDLYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFEYAVKNNRKKVMCLSKDNIMK
ECCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
FSDGILHKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAE
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
ISGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATL
HCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
IENAWKKTIEDGVHTADIYNEQSSSKKVGTKEFAAEVTKRLGQLPTKLPKADYPLIAEKQ
HHHHHHHHHHCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
ESNIDYKIDTKEVKKLVGTDIFVNMNVSSAHDIADKINKLDLGNFELKTISSKGLKLWPR
CCCCCEEECHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCEECCC
DTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSTANIDFIKVENLFEFDGVAGYSLA
CCCCCCCCCCHHHEECCCCCCEEEEHHHHHHHHHHHHCCCEEEEECCCHHCCCCCCCCCC
QGE
CCC
>Mature Secondary Structure 
AEFTPITIAYGDGIGPEIMEAVLYILRKAEARICLETIEVGEKLYKKHYTSGISEESWE
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIQRTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPVVSFHPFTRTLHPNLNLTII
HHHHCCCEEECCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHEEECCCCEEECCCCEEEEE
RENEEDLYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFEYAVKNNRKKVMCLSKDNIMK
ECCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
FSDGILHKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAE
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHH
ISGSVGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATL
HCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
IENAWKKTIEDGVHTADIYNEQSSSKKVGTKEFAAEVTKRLGQLPTKLPKADYPLIAEKQ
HHHHHHHHHHCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
ESNIDYKIDTKEVKKLVGTDIFVNMNVSSAHDIADKINKLDLGNFELKTISSKGLKLWPR
CCCCCEEECHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCEECCC
DTRFETVSDHWCCRFMNKDGTEIKHLDITRLLEALSTANIDFIKVENLFEFDGVAGYSLA
CCCCCCCCCCHHHEECCCCCCEEEEHHHHHHHHHHHHCCCEEEEECCCHHCCCCCCCCCC
QGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]