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The map label for this gene is mpp [C]

Identifier: 229586465

GI number: 229586465

Start: 298592

End: 299827

Strand: Direct

Name: mpp [C]

Synonym: RAF_ORF0273

Alternate gene names: 229586465

Gene position: 298592-299827 (Clockwise)

Preceding gene: 229586464

Following gene: 229586466

Centisome position: 23.35

GC content: 31.47

Gene sequence:

>1236_bases
ATGGAAAATTTTAATGTTAGTAAATTAAAAAACGGTTTGACAATTTTAACATATAATATGCCTTATGTTAATTCGGTAGC
AATAAATTTAATTGCTAAAGTTGGAGCACGTTATGAGAATGCAGAAGAGGATGGCATATCTCACTTTCTTGAGCATATGG
CTTTTAAAGGTACAAAAACTAGAACGGCAAAACAGATAGCGGAAGCGTTTGACTCTATAGGCGGACATTTTAATGCCTAT
ACCGGTCATGAGAATACGGTATATTATGCGCGAGTCTTGTCTGAAAATTGTGATAAAGCACTTAATATACTTGCCGATAT
AATTCAAAATTCTATTTTTTCTGATGAGGAAATAGCTAAGGAATATCAGGTGATCATGCAGGAAATTGCTCATCATCAGG
ATAATCCAGATGACCTAGTATATGAGAAATTTTATAATAAAGTTTATAGAGAACAACCGTTGGGTAAGTCAATCTTAGGT
ACTGCTAAAACCCTTGCAACTTTTACGAAAGAACATTTTTTTAATTTTATAGATAAACATTATAATGCTGAAAATCTCTA
TTTATCAATTGCCGGTAATATTGATCATGATAAAATAGTAATTATAGCGGAACAGTTATTTTCTTCTTTGAAGCAAGGAG
TAAAAAGTAGCTTTATTCCGGCAAAATATATAGGCGGAAATGACTTTATTAATAAGGAGTTAGAGCAAACTAGTTTAGTG
CTAGGGTTTGAAGGTACATCATATATTAATTTAGAAAAGCTTTACCAAACCCATCTACTTTCTATAATATTCGGTGGCGG
TATGTCATCGCGTTTATTTCAAAGTATTCGTGAGAAATTAGGTTTAGCATATGCAGTAGGTAGTTATAATAGTGCTTATT
TTGATAGTGGAGTGTTTACAATTTATGCATCCACTGCACATGATAAATTAGAATTATTATATAGAGAGATTAAAAACGAA
ATAATAAAAATGACTGAACAAGTAAGCACAGAAGAGATTCTTAGAGCTAAAACACAACTACGTAGTAATTTACAAATGGC
TCAAGAGAAAAATACCTATAAGTCAGAAGAAATAGGTAAAAATTATTCTGTTTTCGGTCAATATATTTCTCCTGAAGAGA
TTATGGAAATTATCATGAGCATAAAAGCTGATGATATTATTAATACGGCAAATAAAATATTTAGTGGTACTACTACGTCG
GCAATTATCGGTCCGAATGATCTTCAGGGATTTTAA

Upstream 100 bases:

>100_bases
GAGCGTGGCAATTTCATGAAGTAATATAAAATTCCTGAGATTGCCACGTCGATGCTATGCATTTCCGCGCAATGACGATT
TAGAAAATAAAAGATAAATT

Downstream 100 bases:

>100_bases
TGATATGCTTGTGTGGATACCAGAGTCGTCATTGCGAGCGGCCGTAGGCTGCGTAGCAATCTCATGAAATAATAACAAGC
TCCTGAGATTGCTTCGTCAA

Product: protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEDGISHFLEHMAFKGTKTRTAKQIAEAFDSIGGHFNAY
TGHENTVYYARVLSENCDKALNILADIIQNSIFSDEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYREQPLGKSILG
TAKTLATFTKEHFFNFIDKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNDFINKELEQTSLV
LGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQSIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKNE
IIKMTEQVSTEEILRAKTQLRSNLQMAQEKNTYKSEEIGKNYSVFGQYISPEEIMEIIMSIKADDIINTANKIFSGTTTS
AIIGPNDLQGF

Sequences:

>Translated_411_residues
MENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEDGISHFLEHMAFKGTKTRTAKQIAEAFDSIGGHFNAY
TGHENTVYYARVLSENCDKALNILADIIQNSIFSDEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYREQPLGKSILG
TAKTLATFTKEHFFNFIDKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNDFINKELEQTSLV
LGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQSIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKNE
IIKMTEQVSTEEILRAKTQLRSNLQMAQEKNTYKSEEIGKNYSVFGQYISPEEIMEIIMSIKADDIINTANKIFSGTTTS
AIIGPNDLQGF
>Mature_411_residues
MENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEDGISHFLEHMAFKGTKTRTAKQIAEAFDSIGGHFNAY
TGHENTVYYARVLSENCDKALNILADIIQNSIFSDEEIAKEYQVIMQEIAHHQDNPDDLVYEKFYNKVYREQPLGKSILG
TAKTLATFTKEHFFNFIDKHYNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNDFINKELEQTSLV
LGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQSIREKLGLAYAVGSYNSAYFDSGVFTIYASTAHDKLELLYREIKNE
IIKMTEQVSTEEILRAKTQLRSNLQMAQEKNTYKSEEIGKNYSVFGQYISPEEIMEIIMSIKADDIINTANKIFSGTTTS
AIIGPNDLQGF

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=418, Percent_Identity=28.4688995215311, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI46593007, Length=426, Percent_Identity=22.7699530516432, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI24308013, Length=430, Percent_Identity=25.5813953488372, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI50592988, Length=413, Percent_Identity=26.1501210653753, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1787770, Length=219, Percent_Identity=27.3972602739726, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=412, Percent_Identity=29.3689320388349, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17553678, Length=375, Percent_Identity=24.2666666666667, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17510601, Length=447, Percent_Identity=22.3713646532438, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17569737, Length=305, Percent_Identity=21.9672131147541, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=404, Percent_Identity=32.9207920792079, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6321813, Length=426, Percent_Identity=25.5868544600939, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21357875, Length=411, Percent_Identity=29.683698296837, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24646943, Length=411, Percent_Identity=29.683698296837, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19921772, Length=437, Percent_Identity=25.1716247139588, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46397; Mature: 46397

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEDGISHFLEHMAFKGTKT
CCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCH
RTAKQIAEAFDSIGGHFNAYTGHENTVYYARVLSENCDKALNILADIIQNSIFSDEEIAK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EYQVIMQEIAHHQDNPDDLVYEKFYNKVYREQPLGKSILGTAKTLATFTKEHFFNFIDKH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
YNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNDFINKELEQTSLV
CCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHEEE
LGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQSIREKLGLAYAVGSYNSAYFDSGVFT
EEECCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHCCCCEEE
IYASTAHDKLELLYREIKNEIIKMTEQVSTEEILRAKTQLRSNLQMAQEKNTYKSEEIGK
EEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
NYSVFGQYISPEEIMEIIMSIKADDIINTANKIFSGTTTSAIIGPNDLQGF
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MENFNVSKLKNGLTILTYNMPYVNSVAINLIAKVGARYENAEEDGISHFLEHMAFKGTKT
CCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCH
RTAKQIAEAFDSIGGHFNAYTGHENTVYYARVLSENCDKALNILADIIQNSIFSDEEIAK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EYQVIMQEIAHHQDNPDDLVYEKFYNKVYREQPLGKSILGTAKTLATFTKEHFFNFIDKH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
YNAENLYLSIAGNIDHDKIVIIAEQLFSSLKQGVKSSFIPAKYIGGNDFINKELEQTSLV
CCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHEEE
LGFEGTSYINLEKLYQTHLLSIIFGGGMSSRLFQSIREKLGLAYAVGSYNSAYFDSGVFT
EEECCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHCCCCEEE
IYASTAHDKLELLYREIKNEIIKMTEQVSTEEILRAKTQLRSNLQMAQEKNTYKSEEIGK
EEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
NYSVFGQYISPEEIMEIIMSIKADDIINTANKIFSGTTTSAIIGPNDLQGF
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]