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The map label for this gene is gyrA [H]

Identifier: 229586449

GI number: 229586449

Start: 276521

End: 279238

Strand: Direct

Name: gyrA [H]

Synonym: RAF_ORF0253

Alternate gene names: 229586449

Gene position: 276521-279238 (Clockwise)

Preceding gene: 229586448

Following gene: 229586450

Centisome position: 21.63

GC content: 38.96

Gene sequence:

>2718_bases
GTGACTGATAAATCTTCTTCTAATTTAGTACCGGTAAATATCGAAGATGAGATGAAAGTATCTTATCTTGATTATGCTAT
GAGCGTTATAGTAAGTAGAGCTATACCGGATGTTCGGGACGGCTTAAAGCCGGTACATCGCCGAATTATCTATTCCATGC
ATGAAGCCGGTAATCATGCTAGTAAACCTTATAGAAAATCCGCTAGAATAGTCGGTGACGTGATGGGTAAATATCATCCG
CACGGCGATAGTGCTATTTACGATGCGTTAGTACGTATGGCACAAGATTTTTCCTTGCGTTTACCGCTTGTAGATGGGCA
GGGTAATTTCGGTTCGATGGATGGTGATGCGGCGGCAGCAATGAGATATACCGAATCTCGAATGGCCAAAGTTTCGTATA
AGCTCGTAGAGGATATCGATAAAGAGACTGTCAGCTTTAACCCTAATTACGATGGTTCTGAAGAAGAGCCTTCCGTACTT
CCTGCAATGTTTCCCAATTTATTGGTGAACGGTAGCGGAGGCATTGCGGTCGGTATGGCAACTAATATCCCGCCTCATAA
TCTTGGTGAGGTTATCGATGCGTGCTGTTTATATATAGATAATAACGATATAGAAATATTAGATTTACTTGAAGTTGTTA
AAGGACCGGATTTTCCTACAGGTTCAATGATTTTAGGTATTAGCGGTATTAGATCGGCATATCTTACCGGTAGAGGGAGT
ATCATTATGCGAGGTCGAGCCGAGATTGAGAATATCGATAATAGCCGTCAAGCAATTATTATTACCGAAATACCGTATAT
GGTAAATAAGGCAAGGCTCGTTGAGAAAATCGCTGAAATGGTTAAGGAAAAGCGTATAGAAGGTATAAGTGATTTACGTG
ATGAATCGAATAAAAACGGTGTAAGGATTTTTATTGAGTTAAAGAAAGACGTAGTTGCTGAAGTAGTCTTAAATCAAATA
TACGCATGTACGCAGCTACAAACTAGCTTCGGTGTTATTATGCTTGCTCTTAAAGACGGGCTACCGAAAGTGATGAATTT
GAAAGAAGTAATTGCAGCTTTCGTTAGTTTTAGGGAAGTAGTAATTACTAACCGTACTATATATTTACTCAATAAAGCAA
GAGATAGAGCTCATATTTTACTAGGACTAACTATTGCCGTTAGTAATATCGATGAAATAATACGTATTATTAAAGCTTCA
AATGACCCGAATGCAGCTAAACAAGAATTAATGGCTCGTCAGTGGGAAGCATTAAATATCCTACCTCTTGTAAAGTTGGT
TGATGATAAAGCAATGTTAAACGAGCAGGGTAAATGTAACTTTACCGAAGTGCAAGCTAAGGCAATCTTAGAAATGAGAT
TGCAACGCCTGACCGCTATGGAGAAAAACAAGCTTGAAGAGGATTTAAAGAACCTAATTACGGAAATCACCGAATATCTT
AATATACTTGGCTCTCGTACAAGGTTACTTGAAATTTTAAAGGAAGAGCTCATTAAAGTTAAAGAAGAATTTGCGACTCC
TCGTCTTACTTCAATTGAATTCGGCGAATTTGATCAAGATATAGAAGATTTAATTCAGCGTGAAGAAATGGTTGTAACCG
TAACGCTTGGCGGGTATATCAAGCGTGTACCTCTAAGTAGCTATCGTGCGCAAAAACGTGGCGGTAAAGGAAGATCAGGG
CTTTCAATGCGTGATGAAGATATTACCACGCAAGTTTTTGTCGGTAGTACCCATACTCCTATGTTGTTCTTCTCAAATAT
CGGTCAGGTTTATAGTTTAAAACTGTATAAACTGCCTTTAAGTAATCCGCAGGGTAAGGGTAGACCGATGGTTAATATAT
TACCGCTGAAAGCAAATGAGCATATTACGAATATTATGCCGCTACCTGAAAATCAGGATGAGAGGGATAATTTAAACATT
ATGTTCGCAACTGCCAAAGGTAATATCAGAAGAAGCGATTTATTAGATTTCACAAAGCTTCAGTCGAACGGTAAAATTGC
TATTAGGCTTGATGAGGACGATAAATTAATAGACGTAAAACCATGTAAAGAAGACGAGCATATTTTACTTGCTACCAAAG
CCGGTAAAGCTTTAAGATTCCCTGTTGAATCGCTGCGTGTTATTAAGAGCCGTACTTCTGATGGGGTACGAGGTATGAAG
CTTGCCAAAGAGGATTCTGTAATTTCTATGACTGTGCTTAAAGGTATTAGTAGTACAAAAGAGGATAGAGATGCTTATTT
ATCTGTGCCGTGGGAGCAGAGATTAGAGATTGCTAAAGGTGAGGTGTTTAATCCTGAAGAACTTGGCGTAAGCTTAACTG
CCCCGGCTATTGTAGAAATGGCAAATTCCGAAGAATTCATTTTAACCGTAACTGAGAACGGTTTTGGTAAGAGAAGCTCA
GCTTATGGCTATAGAATTACTGACCGTGGCGGTAGCGGTATAATCAATATGGATATTAACGACAAAACTGGTTTAGTCGT
TGGTGTTATGCCGGTTAAAATGGATGATGAGTTAATGCTGATTACCAATAGCGGTAAGTTAATTCGCTGTAAACTTGAGT
CAGTACGTATTACGGGACGTAACACTAGCGGCGTAATCCTATTTAAGTTAGATGATGGTGAAAAAGTCGTGTCTGTCTCT
TTAATTGCTGAAACTGCTGAAAGTGAAGAAGATAGTGAGTTAGAGGAAGAGGGATTAGAGCAATCTGAAGAGGTGTAA

Upstream 100 bases:

>100_bases
TAGAAATAATACCACGATTATAAATACAAGCAATCCTTGAAAGAAATTTATTATGTCTCTATTATTAAATATAATTCATT
AAATTTAAGGCTAAGTAATC

Downstream 100 bases:

>100_bases
GGGCTGAGGCGTTGTTATTCCAGCATAGCTCTTAAAAAGCTCTCGATGTCATTCTTGCGAAAGCATTTTGCATAGATACC
TAAGTCGTCATTGCGAGGAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 905; Mature: 904

Protein sequence:

>905_residues
MTDKSSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHP
HGDSAIYDALVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSYKLVEDIDKETVSFNPNYDGSEEEPSVL
PAMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
IIMRGRAEIENIDNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQI
YACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDRAHILLGLTIAVSNIDEIIRIIKAS
NDPNAAKQELMARQWEALNILPLVKLVDDKAMLNEQGKCNFTEVQAKAILEMRLQRLTAMEKNKLEEDLKNLITEITEYL
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRAQKRGGKGRSG
LSMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKANEHITNIMPLPENQDERDNLNI
MFATAKGNIRRSDLLDFTKLQSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
LAKEDSVISMTVLKGISSTKEDRDAYLSVPWEQRLEIAKGEVFNPEELGVSLTAPAIVEMANSEEFILTVTENGFGKRSS
AYGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVS
LIAETAESEEDSELEEEGLEQSEEV

Sequences:

>Translated_905_residues
MTDKSSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHP
HGDSAIYDALVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSYKLVEDIDKETVSFNPNYDGSEEEPSVL
PAMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
IIMRGRAEIENIDNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQI
YACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDRAHILLGLTIAVSNIDEIIRIIKAS
NDPNAAKQELMARQWEALNILPLVKLVDDKAMLNEQGKCNFTEVQAKAILEMRLQRLTAMEKNKLEEDLKNLITEITEYL
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRAQKRGGKGRSG
LSMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKANEHITNIMPLPENQDERDNLNI
MFATAKGNIRRSDLLDFTKLQSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
LAKEDSVISMTVLKGISSTKEDRDAYLSVPWEQRLEIAKGEVFNPEELGVSLTAPAIVEMANSEEFILTVTENGFGKRSS
AYGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVS
LIAETAESEEDSELEEEGLEQSEEV
>Mature_904_residues
TDKSSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHASKPYRKSARIVGDVMGKYHPH
GDSAIYDALVRMAQDFSLRLPLVDGQGNFGSMDGDAAAAMRYTESRMAKVSYKLVEDIDKETVSFNPNYDGSEEEPSVLP
AMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGSI
IMRGRAEIENIDNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGVRIFIELKKDVVAEVVLNQIY
ACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDRAHILLGLTIAVSNIDEIIRIIKASN
DPNAAKQELMARQWEALNILPLVKLVDDKAMLNEQGKCNFTEVQAKAILEMRLQRLTAMEKNKLEEDLKNLITEITEYLN
ILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRAQKRGGKGRSGL
SMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKANEHITNIMPLPENQDERDNLNIM
FATAKGNIRRSDLLDFTKLQSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMKL
AKEDSVISMTVLKGISSTKEDRDAYLSVPWEQRLEIAKGEVFNPEELGVSLTAPAIVEMANSEEFILTVTENGFGKRSSA
YGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELMLITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSL
IAETAESEEDSELEEEGLEQSEEV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=345, Percent_Identity=24.9275362318841, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI19913406, Length=359, Percent_Identity=24.7910863509749, Blast_Score=77, Evalue=1e-13,
Organism=Escherichia coli, GI1788562, Length=910, Percent_Identity=47.6923076923077, Blast_Score=850, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=740, Percent_Identity=35, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI212645845, Length=195, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=171, Percent_Identity=30.9941520467836, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=169, Percent_Identity=31.9526627218935, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=284, Percent_Identity=25.7042253521127, Blast_Score=70, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 100745; Mature: 100613

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKSSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHA
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SKPYRKSARIVGDVMGKYHPHGDSAIYDALVRMAQDFSLRLPLVDGQGNFGSMDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHH
MRYTESRMAKVSYKLVEDIDKETVSFNPNYDGSEEEPSVLPAMFPNLLVNGSGGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCEEEEEE
TNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
CCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHEEECCCC
IIMRGRAEIENIDNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNG
EEEECCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VRIFIELKKDVVAEVVLNQIYACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHCHHHHHHHHHHHHHH
VITNRTIYLLNKARDRAHILLGLTIAVSNIDEIIRIIKASNDPNAAKQELMARQWEALNI
EEECCEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCH
LPLVKLVDDKAMLNEQGKCNFTEVQAKAILEMRLQRLTAMEKNKLEEDLKNLITEITEYL
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYI
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCEE
KRVPLSSYRAQKRGGKGRSGLSMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPL
EECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEEEEEECC
SNPQGKGRPMVNILPLKANEHITNIMPLPENQDERDNLNIMFATAKGNIRRSDLLDFTKL
CCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
QSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
CCCCEEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCE
LAKEDSVISMTVLKGISSTKEDRDAYLSVPWEQRLEIAKGEVFNPEELGVSLTAPAIVEM
ECCCCCEEEHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCCCCHHHCCEEEECCHHHEE
ANSEEFILTVTENGFGKRSSAYGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELML
CCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEEEEEEEEECCCEEE
ITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSLIAETAESEEDSELEEEGLE
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEEHHHCCCCCCHHHHHHCCH
QSEEV
HHCCC
>Mature Secondary Structure 
TDKSSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SKPYRKSARIVGDVMGKYHPHGDSAIYDALVRMAQDFSLRLPLVDGQGNFGSMDGDAAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHH
MRYTESRMAKVSYKLVEDIDKETVSFNPNYDGSEEEPSVLPAMFPNLLVNGSGGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCEEEEEE
TNIPPHNLGEVIDACCLYIDNNDIEILDLLEVVKGPDFPTGSMILGISGIRSAYLTGRGS
CCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHEEECCCC
IIMRGRAEIENIDNSRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNG
EEEECCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VRIFIELKKDVVAEVVLNQIYACTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHCHHHHHHHHHHHHHH
VITNRTIYLLNKARDRAHILLGLTIAVSNIDEIIRIIKASNDPNAAKQELMARQWEALNI
EEECCEEEEEECCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCH
LPLVKLVDDKAMLNEQGKCNFTEVQAKAILEMRLQRLTAMEKNKLEEDLKNLITEITEYL
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NILGSRTRLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYI
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEEECCEE
KRVPLSSYRAQKRGGKGRSGLSMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPL
EECCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCEEEEEEEEECC
SNPQGKGRPMVNILPLKANEHITNIMPLPENQDERDNLNIMFATAKGNIRRSDLLDFTKL
CCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
QSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKAGKALRFPVESLRVIKSRTSDGVRGMK
CCCCEEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCE
LAKEDSVISMTVLKGISSTKEDRDAYLSVPWEQRLEIAKGEVFNPEELGVSLTAPAIVEM
ECCCCCEEEHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCCCCHHHCCEEEECCHHHEE
ANSEEFILTVTENGFGKRSSAYGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELML
CCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEEEEEEEEECCCEEE
ITNSGKLIRCKLESVRITGRNTSGVILFKLDDGEKVVSVSLIAETAESEEDSELEEEGLE
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEEEEHHHCCCCCCHHHHHHCCH
QSEEV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA