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The map label for this gene is trxA

Identifier: 229586232

GI number: 229586232

Start: 1040

End: 1357

Strand: Direct

Name: trxA

Synonym: RAF_ORF0002

Alternate gene names: 229586232

Gene position: 1040-1357 (Clockwise)

Preceding gene: 229586231

Following gene: 229586233

Centisome position: 0.08

GC content: 29.87

Gene sequence:

>318_bases
ATGGCAAATAACGTAATGGATAGCTCTTTTAAAAAGGAAGTATTAGAATCGGATTTACCTGTACTGGTTGATTTTTGGGC
AGAATGGTGCGGACCGTGTAAAATGTTAACACCGATAATAGATGAAATCAGTAAAGAATTACAAGGCAAAGTAAAAGTAC
TTAAAATGAATATTGATGAAAATCCTAACACTCCTTCAGAATACGGTATTCGTAGTATTCCAACGATAATGTTATTTAAA
AATGGTGAACAAAAAGATACTAAAATAGGTTTGCAACAAAAAAATTCTCTTTTAGATTGGATTAATAAATCTATTTAA

Upstream 100 bases:

>100_bases
TGTTGCATAGATTGAAAAACCTACTCGATGTCATCCCCGCCTACACGCGGGAATGACATGAAAGCCATATGGACAATGCT
ACAAAAACATAGAGGAATTT

Downstream 100 bases:

>100_bases
TATTTATTTTATGTCACTTAGCTATTCAAAAGTATTTATAGAGATAACTAATGGTTATGTTGAAGGTATTGATACTCATA
AAAGAGCTCAAGGTTTAAAG

Product: Thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MANNVMDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKELQGKVKVLKMNIDENPNTPSEYGIRSIPTIMLFK
NGEQKDTKIGLQQKNSLLDWINKSI

Sequences:

>Translated_105_residues
MANNVMDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKELQGKVKVLKMNIDENPNTPSEYGIRSIPTIMLFK
NGEQKDTKIGLQQKNSLLDWINKSI
>Mature_104_residues
ANNVMDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKELQGKVKVLKMNIDENPNTPSEYGIRSIPTIMLFKN
GEQKDTKIGLQQKNSLLDWINKSI

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=103, Percent_Identity=35.9223300970874, Blast_Score=83, Evalue=5e-17,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=40.9638554216867, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=53.921568627451, Blast_Score=129, Evalue=6e-32,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=45.1612903225806, Blast_Score=99, Evalue=7e-23,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=41.304347826087, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=82, Percent_Identity=37.8048780487805, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=106, Percent_Identity=36.7924528301887, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=106, Percent_Identity=36.7924528301887, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=106, Percent_Identity=36.7924528301887, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=71, Percent_Identity=39.4366197183099, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=92, Percent_Identity=33.695652173913, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=40.2597402597403, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=34.9397590361446, Blast_Score=65, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=30.1204819277108, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=35.4166666666667, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=40.2597402597403, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=36.4583333333333, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=41.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=41.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=40.9836065573771, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=34.4086021505376, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=86, Percent_Identity=36.046511627907, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_RICCN (Q92JR5)

Other databases:

- EMBL:   AE006914
- PIR:   B97700
- RefSeq:   NP_359639.1
- ProteinModelPortal:   Q92JR5
- SMR:   Q92JR5
- GeneID:   928661
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC0002
- OMA:   LIEWINN
- ProtClustDB:   CLSK881870
- BioCyc:   RCON272944:RC0002-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11971; Mature: 11840

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNVMDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKELQGKVKVLKMNIDE
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPNTPSEYGIRSIPTIMLFKNGEQKDTKIGLQQKNSLLDWINKSI
CCCCCHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANNVMDSSFKKEVLESDLPVLVDFWAEWCGPCKMLTPIIDEISKELQGKVKVLKMNIDE
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPNTPSEYGIRSIPTIMLFKNGEQKDTKIGLQQKNSLLDWINKSI
CCCCCHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893