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The map label for this gene is coxL [H]

Identifier: 227828789

GI number: 227828789

Start: 2381989

End: 2384277

Strand: Direct

Name: coxL [H]

Synonym: M1425_2563

Alternate gene names: 227828789

Gene position: 2381989-2384277 (Clockwise)

Preceding gene: 227828788

Following gene: 227828791

Centisome position: 91.3

GC content: 38.14

Gene sequence:

>2289_bases
GTGACCTTGTATATTGGTAGTCCAGTTAAGAGAGTTGAAGATTTACGATTTTTGACTGGAAAAGGTAGATACATTGACGA
CATTTACTTTCCTAACATGCTATACATGGCAGTATTGAGGTCGAATTACGCCTGGACTAAATTCAAGATTGATCCCAAAA
GAGTTGAGGAAAGAGGTTTCAGCGTAATAACGTTTGAAGATACAAAGGAATTTTCGCCATTGCCCAATTTTTTCGTCCCT
GATCCTAAGAGAGTACCAAAGGAGTATATTTTAGCTAAAGATGAGGCAAAGTATTTTGGAGAACCAATAGGATTAGTATT
AGGTAGGGATAGATATGAGGCTTATGATGCATTGGAACTAATTGATGTGGATTATGAGCCTAGAGAGCCGATAACTGATC
CGTTTAAGGCAATAGGTCCTAACTCACCTACTTTACACAAAGAACTAGGCTCCAACATTGTGTATAGCGATATTTTCGAA
TATGGAGAGGAGCCAAAGGATTACAATTACATAGAAAAAAAGTTTAGATATAATAGGATCCTACCGGCTCCTCTTGAAAC
CAATGGGGTAATAGCTGAATTTGATAAGATTAGCGGAAACTTAACAATATATGCAAATACACAAGTTCCACAAGTCTTTA
AGACGGCATTGAGCATTATCTTCAATATTCCTAGATCTAAGGTCAGGATAATTGTCCCAGACTCTGGAGGAGGGTTTGGC
GGAAAGATCTTTCTAAAACCCATAGCCATGACAGCATTAGCCTCAATAATAACTGGAAGGCCGGTAAAGTATATAGAGAC
TCGATATGAACATATAATTTCTGCAATTCATGGACCAGATAGACATTACACTGCAAAGATTTTATATAAGGGGGATGAAC
TATTAGGAGCAATAATTGACTTAGTAGAGGACTTTGGGGCATATTTGCACACTTACCAACCCTTACCAATTCTCAGACAA
ATATATCAATTGGTTGGTCCATATAAAATGAAATACCTTAAGTTCAGAGTATCCGGAGTAGTTACGAATAAACCACCAAC
GGGGGCATATAGGGGACTAGGAATTCCACCAGCAGTTCTAGTATTGGAAAACCTCGTGAAAAGCGTTTCTAAAGTAAGTA
AAATTGATGAAATGGAATTAAGAATGAAAAATTTCATTGATAAACTTCCTTATGAACACATAACGGGTGCAGTATATGAT
AGTGGAAATTACAGAGAGGCATTAAAGAAACTTGTTAGTCAACTGGAGGTAAAGGACAAGGATAAGTACACAGGAATTGG
GATAGCATTGGCATTGGAACCCGGATCTTCCTTAGCTTTCCAAACGCTAGTTGTCAATAAACCTAGGACACCTTACTATG
AGGGTGTGTATATGAGGATAGATAGCGGAGGCGACGTTACGGTGTTTCTCTCAACTAATACTATGGGTACAGGGCATGAA
ACTAGTATATCCCAAGTAGTTGCTGATGTTCTAGGTATTCCGATTGATGACGTGAAAGTCGTATTAGGCGATACTGCAGG
TCCCCCAGGGACAGGATTTTATGGTAGCAGATTCTCTGTAGTCGGTATTTCAGCTGTTTACACCGCTGCCCTAAAATTAA
AGGAAAAAATGAGAGAGTACTTAGCTAAAATGTTCAACGTTGAAAAAGACGAGGTAAAAATAGATAATGGAATAGTAAAA
ATAAGTAACAAGTCGTTCTCTATTAAGGAAGCAGTTAACATGATATATAACAGATCGTACTTAATAGGAGACGAAATAGG
ATTAGACGTTTCTGTTACCATCAATTCATATAATGTAAACGTAGCTGATGATAAGAGAAGAGTGAATTTCTCCACGACCT
ATGGTGTTAACGCACATGGTGTAGTAATTAAAGTTGATAAGGATACTGGATTTATAAAAATACTTAAGTACGTAGTATTG
AGCGATTGCGGAACTATGATAAACCCAATGATAGTGGATGGACAACTAATGGGAGGTACTACAATGGGGATAGGAGCATC
GCTCTTAGAGAAAGTTGAATATGATGAAAATGGGATTCCAAGGCAAACTTCTTTTGCAGACTATTGGATTCCATCGGCAG
AAGAGGTACCTAAATTCGAGATCCAACATATGATTAGCCCTTCACCTTTTACACCACTAGGCACTAAAGGTGTTGCGGAA
GGAGGAGCTACTGTACCTCCAGCTGCTATCATTAATGCCTTAGAGGACATACTAAAGAAACCAATCAATAGGATTGAAAT
ACCAATAACTCCAGAGTATGTATTACAGCTAATTAACGACATGAGCTAG

Upstream 100 bases:

>100_bases
TAAGGGATCTACAAATAATGAAAACATATGAAGGGACAAACGATATTCAAAGGATTAGTGCAGCAAGATTTCTTTACAAT
AAATTCATTGGTTATAAGGT

Downstream 100 bases:

>100_bases
TTATCGCATTCAAAATTTCCTCTTCTTTTCCCTTCCCTTTACCCAAAGTAACGTATTCAATAACCTCGCTGATCAACTGT
TTTAAAGTATCCTCATCTTC

Product: aldehyde oxidase and xanthine dehydrogenasemolybdopterin binding

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MTLYIGSPVKRVEDLRFLTGKGRYIDDIYFPNMLYMAVLRSNYAWTKFKIDPKRVEERGFSVITFEDTKEFSPLPNFFVP
DPKRVPKEYILAKDEAKYFGEPIGLVLGRDRYEAYDALELIDVDYEPREPITDPFKAIGPNSPTLHKELGSNIVYSDIFE
YGEEPKDYNYIEKKFRYNRILPAPLETNGVIAEFDKISGNLTIYANTQVPQVFKTALSIIFNIPRSKVRIIVPDSGGGFG
GKIFLKPIAMTALASIITGRPVKYIETRYEHIISAIHGPDRHYTAKILYKGDELLGAIIDLVEDFGAYLHTYQPLPILRQ
IYQLVGPYKMKYLKFRVSGVVTNKPPTGAYRGLGIPPAVLVLENLVKSVSKVSKIDEMELRMKNFIDKLPYEHITGAVYD
SGNYREALKKLVSQLEVKDKDKYTGIGIALALEPGSSLAFQTLVVNKPRTPYYEGVYMRIDSGGDVTVFLSTNTMGTGHE
TSISQVVADVLGIPIDDVKVVLGDTAGPPGTGFYGSRFSVVGISAVYTAALKLKEKMREYLAKMFNVEKDEVKIDNGIVK
ISNKSFSIKEAVNMIYNRSYLIGDEIGLDVSVTINSYNVNVADDKRRVNFSTTYGVNAHGVVIKVDKDTGFIKILKYVVL
SDCGTMINPMIVDGQLMGGTTMGIGASLLEKVEYDENGIPRQTSFADYWIPSAEEVPKFEIQHMISPSPFTPLGTKGVAE
GGATVPPAAIINALEDILKKPINRIEIPITPEYVLQLINDMS

Sequences:

>Translated_762_residues
MTLYIGSPVKRVEDLRFLTGKGRYIDDIYFPNMLYMAVLRSNYAWTKFKIDPKRVEERGFSVITFEDTKEFSPLPNFFVP
DPKRVPKEYILAKDEAKYFGEPIGLVLGRDRYEAYDALELIDVDYEPREPITDPFKAIGPNSPTLHKELGSNIVYSDIFE
YGEEPKDYNYIEKKFRYNRILPAPLETNGVIAEFDKISGNLTIYANTQVPQVFKTALSIIFNIPRSKVRIIVPDSGGGFG
GKIFLKPIAMTALASIITGRPVKYIETRYEHIISAIHGPDRHYTAKILYKGDELLGAIIDLVEDFGAYLHTYQPLPILRQ
IYQLVGPYKMKYLKFRVSGVVTNKPPTGAYRGLGIPPAVLVLENLVKSVSKVSKIDEMELRMKNFIDKLPYEHITGAVYD
SGNYREALKKLVSQLEVKDKDKYTGIGIALALEPGSSLAFQTLVVNKPRTPYYEGVYMRIDSGGDVTVFLSTNTMGTGHE
TSISQVVADVLGIPIDDVKVVLGDTAGPPGTGFYGSRFSVVGISAVYTAALKLKEKMREYLAKMFNVEKDEVKIDNGIVK
ISNKSFSIKEAVNMIYNRSYLIGDEIGLDVSVTINSYNVNVADDKRRVNFSTTYGVNAHGVVIKVDKDTGFIKILKYVVL
SDCGTMINPMIVDGQLMGGTTMGIGASLLEKVEYDENGIPRQTSFADYWIPSAEEVPKFEIQHMISPSPFTPLGTKGVAE
GGATVPPAAIINALEDILKKPINRIEIPITPEYVLQLINDMS
>Mature_761_residues
TLYIGSPVKRVEDLRFLTGKGRYIDDIYFPNMLYMAVLRSNYAWTKFKIDPKRVEERGFSVITFEDTKEFSPLPNFFVPD
PKRVPKEYILAKDEAKYFGEPIGLVLGRDRYEAYDALELIDVDYEPREPITDPFKAIGPNSPTLHKELGSNIVYSDIFEY
GEEPKDYNYIEKKFRYNRILPAPLETNGVIAEFDKISGNLTIYANTQVPQVFKTALSIIFNIPRSKVRIIVPDSGGGFGG
KIFLKPIAMTALASIITGRPVKYIETRYEHIISAIHGPDRHYTAKILYKGDELLGAIIDLVEDFGAYLHTYQPLPILRQI
YQLVGPYKMKYLKFRVSGVVTNKPPTGAYRGLGIPPAVLVLENLVKSVSKVSKIDEMELRMKNFIDKLPYEHITGAVYDS
GNYREALKKLVSQLEVKDKDKYTGIGIALALEPGSSLAFQTLVVNKPRTPYYEGVYMRIDSGGDVTVFLSTNTMGTGHET
SISQVVADVLGIPIDDVKVVLGDTAGPPGTGFYGSRFSVVGISAVYTAALKLKEKMREYLAKMFNVEKDEVKIDNGIVKI
SNKSFSIKEAVNMIYNRSYLIGDEIGLDVSVTINSYNVNVADDKRRVNFSTTYGVNAHGVVIKVDKDTGFIKILKYVVLS
DCGTMINPMIVDGQLMGGTTMGIGASLLEKVEYDENGIPRQTSFADYWIPSAEEVPKFEIQHMISPSPFTPLGTKGVAEG
GATVPPAAIINALEDILKKPINRIEIPITPEYVLQLINDMS

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI91823271, Length=807, Percent_Identity=23.4200743494424, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI71773480, Length=804, Percent_Identity=22.636815920398, Blast_Score=107, Evalue=4e-23,
Organism=Escherichia coli, GI1789230, Length=792, Percent_Identity=25, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1789246, Length=831, Percent_Identity=23.5860409145608, Blast_Score=169, Evalue=8e-43,
Organism=Escherichia coli, GI1786478, Length=781, Percent_Identity=23.8156209987196, Blast_Score=125, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24647193, Length=735, Percent_Identity=23.6734693877551, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647199, Length=795, Percent_Identity=21.0062893081761, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 84970; Mature: 84839

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYIGSPVKRVEDLRFLTGKGRYIDDIYFPNMLYMAVLRSNYAWTKFKIDPKRVEERGF
CEEEECCHHHHHHHHHEECCCCCEECHHHCHHHHHHHHHHCCCCEEEEEECHHHHHHCCC
SVITFEDTKEFSPLPNFFVPDPKRVPKEYILAKDEAKYFGEPIGLVLGRDRYEAYDALEL
EEEEECCCCCCCCCCCCCCCCHHHCCHHHHEECCCHHHCCCCEEEEECCCHHHHHCCEEE
IDVDYEPREPITDPFKAIGPNSPTLHKELGSNIVYSDIFEYGEEPKDYNYIEKKFRYNRI
EECCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCC
LPAPLETNGVIAEFDKISGNLTIYANTQVPQVFKTALSIIFNIPRSKVRIIVPDSGGGFG
CCCCCCCCCEEEEHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
GKIFLKPIAMTALASIITGRPVKYIETRYEHIISAIHGPDRHYTAKILYKGDELLGAIID
CEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHH
LVEDFGAYLHTYQPLPILRQIYQLVGPYKMKYLKFRVSGVVTNKPPTGAYRGLGIPPAVL
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHEEEEEEEEEEEEECCCCCCCCCCCCCCHHHH
VLENLVKSVSKVSKIDEMELRMKNFIDKLPYEHITGAVYDSGNYREALKKLVSQLEVKDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEEEECCCCHHHHHHHHHHHCCCCCC
DKYTGIGIALALEPGSSLAFQTLVVNKPRTPYYEGVYMRIDSGGDVTVFLSTNTMGTGHE
CCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
TSISQVVADVLGIPIDDVKVVLGDTAGPPGTGFYGSRFSVVGISAVYTAALKLKEKMREY
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LAKMFNVEKDEVKIDNGIVKISNKSFSIKEAVNMIYNRSYLIGDEIGLDVSVTINSYNVN
HHHHHCCCHHHEEECCCEEEECCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEE
VADDKRRVNFSTTYGVNAHGVVIKVDKDTGFIKILKYVVLSDCGTMINPMIVDGQLMGGT
ECCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHCCEEECCEEECCC
TMGIGASLLEKVEYDENGIPRQTSFADYWIPSAEEVPKFEIQHMISPSPFTPLGTKGVAE
CHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
GGATVPPAAIINALEDILKKPINRIEIPITPEYVLQLINDMS
CCCCCCHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TLYIGSPVKRVEDLRFLTGKGRYIDDIYFPNMLYMAVLRSNYAWTKFKIDPKRVEERGF
EEEECCHHHHHHHHHEECCCCCEECHHHCHHHHHHHHHHCCCCEEEEEECHHHHHHCCC
SVITFEDTKEFSPLPNFFVPDPKRVPKEYILAKDEAKYFGEPIGLVLGRDRYEAYDALEL
EEEEECCCCCCCCCCCCCCCCHHHCCHHHHEECCCHHHCCCCEEEEECCCHHHHHCCEEE
IDVDYEPREPITDPFKAIGPNSPTLHKELGSNIVYSDIFEYGEEPKDYNYIEKKFRYNRI
EECCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCC
LPAPLETNGVIAEFDKISGNLTIYANTQVPQVFKTALSIIFNIPRSKVRIIVPDSGGGFG
CCCCCCCCCEEEEHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
GKIFLKPIAMTALASIITGRPVKYIETRYEHIISAIHGPDRHYTAKILYKGDELLGAIID
CEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHH
LVEDFGAYLHTYQPLPILRQIYQLVGPYKMKYLKFRVSGVVTNKPPTGAYRGLGIPPAVL
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHEEEEEEEEEEEEECCCCCCCCCCCCCCHHHH
VLENLVKSVSKVSKIDEMELRMKNFIDKLPYEHITGAVYDSGNYREALKKLVSQLEVKDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEEEECCCCHHHHHHHHHHHCCCCCC
DKYTGIGIALALEPGSSLAFQTLVVNKPRTPYYEGVYMRIDSGGDVTVFLSTNTMGTGHE
CCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCC
TSISQVVADVLGIPIDDVKVVLGDTAGPPGTGFYGSRFSVVGISAVYTAALKLKEKMREY
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LAKMFNVEKDEVKIDNGIVKISNKSFSIKEAVNMIYNRSYLIGDEIGLDVSVTINSYNVN
HHHHHCCCHHHEEECCCEEEECCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEE
VADDKRRVNFSTTYGVNAHGVVIKVDKDTGFIKILKYVVLSDCGTMINPMIVDGQLMGGT
ECCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHHCCEEECCEEECCC
TMGIGASLLEKVEYDENGIPRQTSFADYWIPSAEEVPKFEIQHMISPSPFTPLGTKGVAE
CHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
GGATVPPAAIINALEDILKKPINRIEIPITPEYVLQLINDMS
CCCCCCHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]