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The map label for this gene is yeaE [H]

Identifier: 227828771

GI number: 227828771

Start: 2364133

End: 2365011

Strand: Direct

Name: yeaE [H]

Synonym: M1425_2545

Alternate gene names: 227828771

Gene position: 2364133-2365011 (Clockwise)

Preceding gene: 227828769

Following gene: 227828772

Centisome position: 90.62

GC content: 39.14

Gene sequence:

>879_bases
ATGGAGGACGTTAAGAAATTTAAATACTTTACCGTATCGTCACTGGCTTTTGGAACTTGGAGAATTGGAGGAGGTTATTG
GTACGCTTCTCATGATAGAGATAACGAGTGGGTGAGTGCGATTCGTAAGGCAATTGAGCTAGGAATAAGGCTCATTGATA
CTGCCGAAATGTATGGAAATGGTCACGCTGAGGAATTAGTAGGTGAGGCAATTAAGGGATTTAATAGAGATGAGCTGTTT
ATAGTCTCCAAGGTTTGGCCTAGCCATGCTGAATATGATAATGTGATAAAGTCAGCTAAAAATAGTTCTAAAAGGCTAGG
CACATACATCGACCTTTATTTACTTCACTCCCCTTCAAGAGTACCCATTTGCAAGACAATAAGTGCATTTGAGAAGTTAG
TTGATGATGGTGTAATAAGGTATTTTGGCCTAAGCAATTTCGATGTAGATCAAATTGAGAGAGCTAGAGAGTGTGTTAGT
AAATACGAGATTGTGGCAATTCAGAATCATTATAGCCTGCTAAATAGGGATGATGAGAGGAAAGCTTTAGCTTATGCAGA
GAAAAATGGATTGATGTACATGGCTTATACTCCATTGGAAAATGGAATATTGGCGAGAAACGAATTCTTAGCAAGCATAG
GTAAGAGGTACAATAAGACTGCTACCCAAGTAGCCTTAAACTGGTATATCACTGGTAGAAATAGTTTAATACCAATAGTT
AAGGCTTCCAAAATACCCCACGTTGAGGAGAATGCTGGTGCAATGGGCTGGAGATTGTCGGAAGAAGATTGGAGGGAAAT
AGATGAGCATTTTAGAGAGAAGAGTTACTTTTTAGATAAATTCGTCTCGTCTCTGAAATCGATAAGACCTTGGTCCTAG

Upstream 100 bases:

>100_bases
TTAATAAATTAAATTATGTACTTATATCCTTTTCTTCCTATATTAGATATGATGTACATTAAGAAGCAATTTTTAAAAGG
TACAAATTTAAGATATATTT

Downstream 100 bases:

>100_bases
TTAATTTTAAATCCATGTAATCGAGTTAATATCTATGAAGAGAATTCTAGTTGGCTATGATGGTTCGGAGAACGCTGAAA
GAGCATTAGATTTCGCAATA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MEDVKKFKYFTVSSLAFGTWRIGGGYWYASHDRDNEWVSAIRKAIELGIRLIDTAEMYGNGHAEELVGEAIKGFNRDELF
IVSKVWPSHAEYDNVIKSAKNSSKRLGTYIDLYLLHSPSRVPICKTISAFEKLVDDGVIRYFGLSNFDVDQIERARECVS
KYEIVAIQNHYSLLNRDDERKALAYAEKNGLMYMAYTPLENGILARNEFLASIGKRYNKTATQVALNWYITGRNSLIPIV
KASKIPHVEENAGAMGWRLSEEDWREIDEHFREKSYFLDKFVSSLKSIRPWS

Sequences:

>Translated_292_residues
MEDVKKFKYFTVSSLAFGTWRIGGGYWYASHDRDNEWVSAIRKAIELGIRLIDTAEMYGNGHAEELVGEAIKGFNRDELF
IVSKVWPSHAEYDNVIKSAKNSSKRLGTYIDLYLLHSPSRVPICKTISAFEKLVDDGVIRYFGLSNFDVDQIERARECVS
KYEIVAIQNHYSLLNRDDERKALAYAEKNGLMYMAYTPLENGILARNEFLASIGKRYNKTATQVALNWYITGRNSLIPIV
KASKIPHVEENAGAMGWRLSEEDWREIDEHFREKSYFLDKFVSSLKSIRPWS
>Mature_292_residues
MEDVKKFKYFTVSSLAFGTWRIGGGYWYASHDRDNEWVSAIRKAIELGIRLIDTAEMYGNGHAEELVGEAIKGFNRDELF
IVSKVWPSHAEYDNVIKSAKNSSKRLGTYIDLYLLHSPSRVPICKTISAFEKLVDDGVIRYFGLSNFDVDQIERARECVS
KYEIVAIQNHYSLLNRDDERKALAYAEKNGLMYMAYTPLENGILARNEFLASIGKRYNKTATQVALNWYITGRNSLIPIV
KASKIPHVEENAGAMGWRLSEEDWREIDEHFREKSYFLDKFVSSLKSIRPWS

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291291012, Length=290, Percent_Identity=30, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=29.7202797202797, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=26.0726072607261, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=25.1748251748252, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=25.1748251748252, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI5174695, Length=268, Percent_Identity=25.7462686567164, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI5453543, Length=300, Percent_Identity=25.3333333333333, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=25.7142857142857, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI24497585, Length=301, Percent_Identity=25.2491694352159, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=24.6666666666667, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=24.6666666666667, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=28.6206896551724, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI27436962, Length=319, Percent_Identity=26.0188087774295, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI27436964, Length=317, Percent_Identity=26.1829652996845, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI27436966, Length=319, Percent_Identity=26.0188087774295, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI27436969, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4504825, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI300116273, Length=266, Percent_Identity=25.187969924812, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788081, Length=260, Percent_Identity=36.9230769230769, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786400, Length=264, Percent_Identity=31.8181818181818, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788070, Length=319, Percent_Identity=30.7210031347962, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081735, Length=308, Percent_Identity=24.6753246753247, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787674, Length=281, Percent_Identity=25.9786476868327, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082198, Length=256, Percent_Identity=29.296875, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789375, Length=284, Percent_Identity=26.056338028169, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789199, Length=330, Percent_Identity=27.8787878787879, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI48994888, Length=285, Percent_Identity=25.6140350877193, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71998625, Length=276, Percent_Identity=27.8985507246377, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550248, Length=301, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17537075, Length=304, Percent_Identity=27.3026315789474, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537077, Length=306, Percent_Identity=27.1241830065359, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=293, Percent_Identity=26.6211604095563, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=322, Percent_Identity=25.776397515528, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17566692, Length=313, Percent_Identity=27.1565495207668, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=282, Percent_Identity=25.886524822695, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322556, Length=279, Percent_Identity=27.5985663082437, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325169, Length=229, Percent_Identity=25.3275109170306, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324694, Length=295, Percent_Identity=26.1016949152542, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24657054, Length=279, Percent_Identity=29.7491039426523, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24663317, Length=272, Percent_Identity=29.7794117647059, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=27.5618374558304, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=29.3333333333333, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=26.1016949152542, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24662789, Length=297, Percent_Identity=27.6094276094276, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=26.1016949152542, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=27.5193798449612, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646159, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646155, Length=155, Percent_Identity=30.3225806451613, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 33634; Mature: 33634

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVKKFKYFTVSSLAFGTWRIGGGYWYASHDRDNEWVSAIRKAIELGIRLIDTAEMYGN
CCCHHHHHHEEEHHHEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHCHHHEEHHHHHCC
GHAEELVGEAIKGFNRDELFIVSKVWPSHAEYDNVIKSAKNSSKRLGTYIDLYLLHSPSR
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHEEEEEEEECCCC
VPICKTISAFEKLVDDGVIRYFGLSNFDVDQIERARECVSKYEIVAIQNHYSLLNRDDER
CCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHEEEEEECHHHHHCCCCHH
KALAYAEKNGLMYMAYTPLENGILARNEFLASIGKRYNKTATQVALNWYITGRNSLIPIV
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCEEEEE
KASKIPHVEENAGAMGWRLSEEDWREIDEHFREKSYFLDKFVSSLKSIRPWS
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEDVKKFKYFTVSSLAFGTWRIGGGYWYASHDRDNEWVSAIRKAIELGIRLIDTAEMYGN
CCCHHHHHHEEEHHHEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHCHHHEEHHHHHCC
GHAEELVGEAIKGFNRDELFIVSKVWPSHAEYDNVIKSAKNSSKRLGTYIDLYLLHSPSR
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHEEEEEEEECCCC
VPICKTISAFEKLVDDGVIRYFGLSNFDVDQIERARECVSKYEIVAIQNHYSLLNRDDER
CCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHEEEEEECHHHHHCCCCHH
KALAYAEKNGLMYMAYTPLENGILARNEFLASIGKRYNKTATQVALNWYITGRNSLIPIV
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCEEEEE
KASKIPHVEENAGAMGWRLSEEDWREIDEHFREKSYFLDKFVSSLKSIRPWS
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]