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The map label for this gene is serA [H]

Identifier: 227828428

GI number: 227828428

Start: 1994574

End: 1995476

Strand: Direct

Name: serA [H]

Synonym: M1425_2174

Alternate gene names: 227828428

Gene position: 1994574-1995476 (Clockwise)

Preceding gene: 227828427

Following gene: 227828429

Centisome position: 76.45

GC content: 36.43

Gene sequence:

>903_bases
ATGAAGATAATATCTACAGAAAAAGTCCCTGAAGAGTGCAAAAATATAATTAATATTAAAGACGAAAATCTAACAGAAGA
AGATTATAAAAATGCAGAGATCTTACTAACGTGGCCAGGAAGAGTAAATAGCGATCTCATAGATAAGATGCCTAACCTTA
AGGTAATACAAACGTTCTCAGCGGGAGTTGATGATTTAAATTTCTCTATAGTTCCTCCACATGTTAAAGTATTCTCAAAT
GCCGGTGCCTATTCTTTATCAGTAGCTGAACACGCTTGGGCTCTAATTTTAGCATTAGCCAAAGGTGTGGGAACAAAAAA
GAGGACTATAGTTTACGACGTTTCTGAAAAAACGTTGTTGGTTTTAGGTGGTGGTGGCATAGGGTCTGAAGTTGCCAGGA
TAGGTAAAACGGCTTTTAGAAATTACGTAATAGGCATTTCCAGATCATTCAGAAAACCTGAATGGTTTGACGAAAAGCAC
GAAATGATAATGATAAGGGAGAAAATTAAAGAGGCTGATATAATTGTCGATACGTTACCTCTAAACAAGCAAACTAGGAG
TCTTTTAAATTATGATCTACTAAAAGATGCAAAGCGTAATGCTATAATTGTTAATGTAGGCAGAGGTGAGACAGTGGATG
AAGAAGGTATTTATAGGTTGCTTAAGGAGAGGCAAGACGTGAGGTTTGGGACTGATGTATTTTGGAGAAAAAACGGTAAG
GAGGATTTCTATAATACAAAGCTATGGGAATTAGATAACTTTACTGGAACGCTTCACACTGCTGGAGCTTATGGTAATGA
GAGCATAATGAAGAGGGCAATGTCCATGGCTTGTTTGAATGTGAAAAAATATATAGATAAGGGAGTTGCAGATAATGAAG
TAAGAAGGGAAGATTATGTTTGA

Upstream 100 bases:

>100_bases
AAGAGGGAAAAAAACTAATAGAGAATTTGAAACTTAGCGGTTTCTGAAGATGACTTTCCTTGTATTAAAAATTAAAAACC
TATGAAGTAAAGTAGGGTTT

Downstream 100 bases:

>100_bases
CAAATCGATGGATAAACAAATAGAGGACTGGTTAAAGGAATTAGGACTAGTTGCGAGTAGACCGCCTCAAGCTAAAGAAT
TCTTTCACGTTGTTGCCACG

Product: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKIISTEKVPEECKNIINIKDENLTEEDYKNAEILLTWPGRVNSDLIDKMPNLKVIQTFSAGVDDLNFSIVPPHVKVFSN
AGAYSLSVAEHAWALILALAKGVGTKKRTIVYDVSEKTLLVLGGGGIGSEVARIGKTAFRNYVIGISRSFRKPEWFDEKH
EMIMIREKIKEADIIVDTLPLNKQTRSLLNYDLLKDAKRNAIIVNVGRGETVDEEGIYRLLKERQDVRFGTDVFWRKNGK
EDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMSMACLNVKKYIDKGVADNEVRREDYV

Sequences:

>Translated_300_residues
MKIISTEKVPEECKNIINIKDENLTEEDYKNAEILLTWPGRVNSDLIDKMPNLKVIQTFSAGVDDLNFSIVPPHVKVFSN
AGAYSLSVAEHAWALILALAKGVGTKKRTIVYDVSEKTLLVLGGGGIGSEVARIGKTAFRNYVIGISRSFRKPEWFDEKH
EMIMIREKIKEADIIVDTLPLNKQTRSLLNYDLLKDAKRNAIIVNVGRGETVDEEGIYRLLKERQDVRFGTDVFWRKNGK
EDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMSMACLNVKKYIDKGVADNEVRREDYV
>Mature_300_residues
MKIISTEKVPEECKNIINIKDENLTEEDYKNAEILLTWPGRVNSDLIDKMPNLKVIQTFSAGVDDLNFSIVPPHVKVFSN
AGAYSLSVAEHAWALILALAKGVGTKKRTIVYDVSEKTLLVLGGGGIGSEVARIGKTAFRNYVIGISRSFRKPEWFDEKH
EMIMIREKIKEADIIVDTLPLNKQTRSLLNYDLLKDAKRNAIIVNVGRGETVDEEGIYRLLKERQDVRFGTDVFWRKNGK
EDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMSMACLNVKKYIDKGVADNEVRREDYV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=27.2373540856031, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324964, Length=248, Percent_Identity=24.1935483870968, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=302, Percent_Identity=26.8211920529801, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34026; Mature: 34026

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIISTEKVPEECKNIINIKDENLTEEDYKNAEILLTWPGRVNSDLIDKMPNLKVIQTFS
CCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHCCCCEEEEEHH
AGVDDLNFSIVPPHVKVFSNAGAYSLSVAEHAWALILALAKGVGTKKRTIVYDVSEKTLL
CCCCCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEE
VLGGGGIGSEVARIGKTAFRNYVIGISRSFRKPEWFDEKHEMIMIREKIKEADIIVDTLP
EEECCCCHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECC
LNKQTRSLLNYDLLKDAKRNAIIVNVGRGETVDEEGIYRLLKERQDVRFGTDVFWRKNGK
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCC
EDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMSMACLNVKKYIDKGVADNEVRREDYV
CCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MKIISTEKVPEECKNIINIKDENLTEEDYKNAEILLTWPGRVNSDLIDKMPNLKVIQTFS
CCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHCCCCEEEEEHH
AGVDDLNFSIVPPHVKVFSNAGAYSLSVAEHAWALILALAKGVGTKKRTIVYDVSEKTLL
CCCCCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEE
VLGGGGIGSEVARIGKTAFRNYVIGISRSFRKPEWFDEKHEMIMIREKIKEADIIVDTLP
EEECCCCHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECC
LNKQTRSLLNYDLLKDAKRNAIIVNVGRGETVDEEGIYRLLKERQDVRFGTDVFWRKNGK
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCC
EDFYNTKLWELDNFTGTLHTAGAYGNESIMKRAMSMACLNVKKYIDKGVADNEVRREDYV
CCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]