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The map label for this gene is 227828343

Identifier: 227828343

GI number: 227828343

Start: 1909930

End: 1910985

Strand: Direct

Name: 227828343

Synonym: M1425_2086

Alternate gene names: NA

Gene position: 1909930-1910985 (Clockwise)

Preceding gene: 227828340

Following gene: 227828345

Centisome position: 73.21

GC content: 36.74

Gene sequence:

>1056_bases
TTGCATAAAACGGCTTTTATATGGACAGATGAATACTATAACTACTCCTTCCCAGACTATCATCCATTTAAATCATTAAG
AGAAAGTATGACTAAGAGATTGCTGGAAGAAAGAAGTGCGTTTCATTTCATCACATTGATTGAACCTAAGCCGATATCAG
AAGAGGTTCTTCAGTTAGTCCACTCCAAAGAATATATAGAATTTGTAAAATATAAGAGCAAGGAAGGTCAAGGATATTTA
GATGATGGAGATACTCCTGCATTTAAGGGTATATATGAGGCTGCATTAATAAGGATAAGTGGTAGTGTAAAGGCATTAGA
ATTAATAAAGGGTGGGGAGTTTAACCACGCGATCAATATTGGTGGGGGTTTTCATCACGCAAAGAGAAATAGAGCTGCTG
GTTTCTGTGTATTTAACGATGTTGCGCTCATAGCAAAATTAGGTGAGAATTCCTTTTCAAAAATAGCAATAGTTGATATA
GATGGTCATCATGCTGATGGTACACAAGAACTATTAATTGATGATGATAAGGTTTTGAAAATTTCCCTGCATATGTTTCA
TCCTAACTTCTTCCCGGGTAGCGGGGATGTGAACGAGATTGGAGTAGGAAAAGGAGAAGGTTATACTATTAACATTCCTC
TACCACCTGGTACTGGAGATGATGGTTATCTTTTAGCATTTGACGAGATAGTAATCCCCGTTATAGAAAGATATAAACCA
GAGCTTATTATCCTCATAACGGGCGGTGATTCATATTTTAACGATCCTTTAGTTGAGTTAAAATTATCCACCCATGGTTA
TTTAGATGTGGTAACAAAGGTCCATCATCTAGCCCATAAGTACTCCAGTGGTAGGCTTATAATGTTGGGAGGAGGTGGAT
ATAACTATGATGCGACTGCTAGAATTTGGACAATTTCAATAGCTGAGATTGCGGGAATATACGACTTAGAGTATGAAACT
CTCCATGATCCCTTCTCTACTAAATCATCACAGTTTGTTATGGAGAAAATAAGAAGCACTATCGATCGAATAAAGAAGAT
ACATTCATTTAACTAA

Upstream 100 bases:

>100_bases
TCCATACTATGTGCAATATATTGTGGCTTTGTGATGAGTGTGCTATCTATCATACTAGATAAGTATTTTAAATTGAAAAA
TAAAAAAGTAGTGATATACT

Downstream 100 bases:

>100_bases
TATTATTGATGACGCCTTTCTGACCTTTTCTATTGCTTCTTCTACGCTATTTCCAGTTGCCAGCACTATACCCATCCTTC
TCTTTTCATATGTAACAGGT

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERSAFHFITLIEPKPISEEVLQLVHSKEYIEFVKYKSKEGQGYL
DDGDTPAFKGIYEAALIRISGSVKALELIKGGEFNHAINIGGGFHHAKRNRAAGFCVFNDVALIAKLGENSFSKIAIVDI
DGHHADGTQELLIDDDKVLKISLHMFHPNFFPGSGDVNEIGVGKGEGYTINIPLPPGTGDDGYLLAFDEIVIPVIERYKP
ELIILITGGDSYFNDPLVELKLSTHGYLDVVTKVHHLAHKYSSGRLIMLGGGGYNYDATARIWTISIAEIAGIYDLEYET
LHDPFSTKSSQFVMEKIRSTIDRIKKIHSFN

Sequences:

>Translated_351_residues
MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERSAFHFITLIEPKPISEEVLQLVHSKEYIEFVKYKSKEGQGYL
DDGDTPAFKGIYEAALIRISGSVKALELIKGGEFNHAINIGGGFHHAKRNRAAGFCVFNDVALIAKLGENSFSKIAIVDI
DGHHADGTQELLIDDDKVLKISLHMFHPNFFPGSGDVNEIGVGKGEGYTINIPLPPGTGDDGYLLAFDEIVIPVIERYKP
ELIILITGGDSYFNDPLVELKLSTHGYLDVVTKVHHLAHKYSSGRLIMLGGGGYNYDATARIWTISIAEIAGIYDLEYET
LHDPFSTKSSQFVMEKIRSTIDRIKKIHSFN
>Mature_351_residues
MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERSAFHFITLIEPKPISEEVLQLVHSKEYIEFVKYKSKEGQGYL
DDGDTPAFKGIYEAALIRISGSVKALELIKGGEFNHAINIGGGFHHAKRNRAAGFCVFNDVALIAKLGENSFSKIAIVDI
DGHHADGTQELLIDDDKVLKISLHMFHPNFFPGSGDVNEIGVGKGEGYTINIPLPPGTGDDGYLLAFDEIVIPVIERYKP
ELIILITGGDSYFNDPLVELKLSTHGYLDVVTKVHHLAHKYSSGRLIMLGGGGYNYDATARIWTISIAEIAGIYDLEYET
LHDPFSTKSSQFVMEKIRSTIDRIKKIHSFN

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=337, Percent_Identity=31.4540059347181, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI13128860, Length=315, Percent_Identity=31.7460317460317, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI13128862, Length=367, Percent_Identity=30.7901907356948, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI293336691, Length=314, Percent_Identity=32.8025477707006, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI262073092, Length=221, Percent_Identity=34.3891402714932, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI13128864, Length=309, Percent_Identity=31.0679611650485, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI262073088, Length=276, Percent_Identity=30.0724637681159, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI30795204, Length=183, Percent_Identity=40.4371584699454, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI30795202, Length=183, Percent_Identity=40.4371584699454, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI17158039, Length=206, Percent_Identity=38.8349514563107, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI20070354, Length=325, Percent_Identity=27.3846153846154, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI153085395, Length=234, Percent_Identity=34.1880341880342, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI148539870, Length=139, Percent_Identity=43.1654676258993, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI169234807, Length=139, Percent_Identity=43.1654676258993, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI62750349, Length=210, Percent_Identity=35.7142857142857, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI62750347, Length=210, Percent_Identity=35.7142857142857, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI226529806, Length=247, Percent_Identity=29.1497975708502, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI209862883, Length=299, Percent_Identity=26.0869565217391, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI217272877, Length=315, Percent_Identity=26.3492063492064, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=314, Percent_Identity=30.5732484076433, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17561978, Length=313, Percent_Identity=32.5878594249201, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534739, Length=321, Percent_Identity=29.9065420560748, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17540332, Length=348, Percent_Identity=26.7241379310345, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193206283, Length=348, Percent_Identity=26.7241379310345, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17540334, Length=348, Percent_Identity=26.7241379310345, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193209491, Length=330, Percent_Identity=28.1818181818182, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25154020, Length=269, Percent_Identity=27.1375464684015, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=254, Percent_Identity=25.9842519685039, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25154022, Length=271, Percent_Identity=26.1992619926199, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193207430, Length=296, Percent_Identity=26.6891891891892, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323999, Length=319, Percent_Identity=29.7805642633229, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321244, Length=348, Percent_Identity=31.0344827586207, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324307, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325325, Length=233, Percent_Identity=33.0472103004292, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657891, Length=310, Percent_Identity=32.258064516129, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24644244, Length=314, Percent_Identity=29.2993630573248, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24642146, Length=305, Percent_Identity=27.8688524590164, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24642144, Length=305, Percent_Identity=27.8688524590164, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24642142, Length=305, Percent_Identity=27.8688524590164, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI281360899, Length=309, Percent_Identity=28.1553398058252, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24641720, Length=140, Percent_Identity=37.8571428571429, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281360801, Length=140, Percent_Identity=37.8571428571429, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281360799, Length=140, Percent_Identity=37.8571428571429, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24649807, Length=307, Percent_Identity=24.7557003257329, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39422; Mature: 39422

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERSAFHFITLIEPKPISEEVLQLV
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
HSKEYIEFVKYKSKEGQGYLDDGDTPAFKGIYEAALIRISGSVKALELIKGGEFNHAINI
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHEEEEEECCCCEEEEEECCCCCCEEEEC
GGGFHHAKRNRAAGFCVFNDVALIAKLGENSFSKIAIVDIDGHHADGTQELLIDDDKVLK
CCCHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEE
ISLHMFHPNFFPGSGDVNEIGVGKGEGYTINIPLPPGTGDDGYLLAFDEIVIPVIERYKP
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHCCCC
ELIILITGGDSYFNDPLVELKLSTHGYLDVVTKVHHLAHKYSSGRLIMLGGGGYNYDATA
CEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEE
RIWTISIAEIAGIYDLEYETLHDPFSTKSSQFVMEKIRSTIDRIKKIHSFN
EEEEEEHHHHCCEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERSAFHFITLIEPKPISEEVLQLV
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
HSKEYIEFVKYKSKEGQGYLDDGDTPAFKGIYEAALIRISGSVKALELIKGGEFNHAINI
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHEEEEEECCCCEEEEEECCCCCCEEEEC
GGGFHHAKRNRAAGFCVFNDVALIAKLGENSFSKIAIVDIDGHHADGTQELLIDDDKVLK
CCCHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEE
ISLHMFHPNFFPGSGDVNEIGVGKGEGYTINIPLPPGTGDDGYLLAFDEIVIPVIERYKP
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHCCCC
ELIILITGGDSYFNDPLVELKLSTHGYLDVVTKVHHLAHKYSSGRLIMLGGGGYNYDATA
CEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEE
RIWTISIAEIAGIYDLEYETLHDPFSTKSSQFVMEKIRSTIDRIKKIHSFN
EEEEEEHHHHCCEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]