Click here to switch to the map view.

The map label for this gene is lhr [C]

Identifier: 227828272

GI number: 227828272

Start: 1845702

End: 1848329

Strand: Direct

Name: lhr [C]

Synonym: M1425_2013

Alternate gene names: 227828272

Gene position: 1845702-1848329 (Clockwise)

Preceding gene: 227828271

Following gene: 227828276

Centisome position: 70.75

GC content: 34.13

Gene sequence:

>2628_bases
TTGAGTAGTACCTACTTTTACGCCGATGAAGAAATATATAACTTACTTAGACCATATGTTGCCAAATGGTTTAAGGAAAA
ATATACCACGTTCACTCCTCCTCAGAGAGCAGCGATACCCTTAATAAAGCAAAACTATAATGTCTTAGTATCAAGCCCTA
CGGGAAGTGGGAAAACTTTAGCTGCGTTTCTAGGAATTTTAGATTCGTTATTTGAATTAGGCGATAACAACGAGTTGGAA
GATAAGGTTTACGCGGTTTATATTTCACCGTTAAGGGCGCTTAACAATGATATGCAAAGAAACCTATTAGAACCTCTTAA
TGAGTTAAAGCAGATAAATCCAAGGTTACCAGATATTAGGGTTAGAATTAGAACCAGTGACACTACACCCTATGAAAAGC
AGAAAATGTTAAAGAAACCTCCACATATTTTAATAACAACACCAGAATCCTTCGGAATATCCATAACTTCACCGAAGTTC
AGCCAGAAATTAACTGATGTGAAATGGGTTATAGTCGATGAAATTCATGAACTAGCTAACAGTAAGAGGGGAGCTTATCT
TTCTGCAATGTTAGAACTATTTAGAAGCCTACTTGCTAAGAAAGAATTTGTAAGAATAGGTCTAAGTGCGACTGTATCAC
CCCTTGAAGAAGTAGCTCAATTTCTTGTGGGCAAAGGCAGAGAGTATAGAATTGTTGACGCTAGATTTGTAAAACCTATT
GATATTAAGGTGATTTCTCCAGTTAAAGATCTAGTTCATTCTTCTGAAAGTGAGGTAGATAAGGGAATATATAAGACTAT
CTTGAATGAAGTAAAAAAGCATAGAACTACTCTTATCTTTACAAATACAAGACATGCTACAGAGAGAGTAGCATATAAGT
TGAGAAAGTTAGCTGAAAATGAAAAGGTCTTTGATGTTGATGCGATAGAAGCTCATCATAGTAGTCTTAGTAGAGATGTG
AGGCTAGATGTTGAAGATAAGCTTAAAAAGGGGATCTTAAAAGTTGTTGTATCATCAACTAGCCTTGAATTAGGAATAGA
CATAGGCTACATAGATTTAGTTGTTTTACTAAGTAGTCCTAAGAGTGTAAGTAGATTATTACAAAGAATAGGGAGAGCTG
GTCATCATATAAGGAGTATTAGTAAAGGAAGAGTGATTGTTGTTGACAGAGATGATTTAGTTGAGTGTTCTGTATTAGCT
AAGTTGGCTAGAGATAGGAAAATTGATAACATTCATATTCCTAAAAATCCATTAGATGTCTTGTCGCAGATAATAGTATC
TGCTAGTTTAATTTCTCCGATAGATAGGGAAGAGTTGTATAATATTCTAAAGCGGTCATATAATTTCTCAGACCTTAATG
AATCTGAGTACTCTTTAGTATTAAGATATCTTAGTGGAGATTTCTTTGGAGTTGAGTTAAAAAACGTTTATGCTAAAATA
CGACTAAAAGAGGAAAAGATTATTTATCCAAAAAAAGGTAGTAGACTGATATTTTACACTAATAGTGGTACAATTCCAGA
TGAGGCTATGATAAGCGTAGTTACTGAGAATAATAGATATGTTGGTAATTTAGAAGAAGAATTTGTTGAAATACTATCAC
CCGGAGATATCTTCGTATTAAGTGGTAGGACCTATGAATTTATTGGGAGCAAAGGTTCAAAGGTAATTGTAAAAGAAGCC
ATAGGTCAAAGGCCAACAGTTCCAAGCTGGTTTTCTGAAATGCTTCCATTAGCCTATGAATCAGCGCTAGAGGTTGGTAA
GTTTAGAAGAGAAATAGCTGAGATGATTAAGAAAGGAGTAACGCATACCGAGATAATACAAAATATTTCTAAGCAATATG
AAATTGATAAACACTCTTCCATGTCAATATATACCTATATTTTAGAGCAATACCTTTTCACGAATGGAAAAGTTCCTTCT
GATAACTTGATTTTAATAGAAATTTATGATGATGAAGAAGGAATTAGGAATTATATTTTTCACGCATTATATGGAAGAAG
AGCATTAGATGCTCTTTCTAGAGCTTTTGCATATGTTCTTAGTGAAGAGTTAAATACAGATGTTAAAGTTTCTGTTACTG
ACAATGGATTTGTGCTTAGTGTGAAAAGAGACATTTCCTTGGATTATGATATTAAGAACCTATTTGAAAAGGTTAATCCA
GATAACGTTTATGAAATAGTTACAAATGCTATTATGAGGACAGAAATGCTAAAGAGAAGATTTAGACACTGCGCAGAGAG
ATCATTTATGATATTGCGAAAATACAAAGGAAGGGAGACTAATCTAGAGAGAAGAGAATTAAATTCAGAGATATTGCTAA
AAGCTGTAAGAGAAATTGAAAATTTTCCAGTGATTAAGGAGACTATCAGAGAGATTTTGGAAGATCATATGGATATAATG
AGAGCTAAGGAGATTCTCAGAAAAGTTGCTGATCACGAAATAACAGTAGATGTATTTGGACCCACTAGCATTCCCAGTCC
ATTTTCCCATAGTATAATACTTAAAGGGCATTCAGATGTAGTACTAGCGGAAGATAGAAGGGAACTAATGAAGAAGCTTC
ATGATAGAGTTATAGAGTTCTTGAGACAGAAGGGAGTTAATATCGAGCTCGAGTATACTTCCGTTTGA

Upstream 100 bases:

>100_bases
TAGCTTACTATTCAATAGCTTTCCTTTATACTTTTATAGCATATATTAAAGGATTATGAAAGAAGTATTTTTTAAATCAT
ATTCTTAAAGGGACTACAAG

Downstream 100 bases:

>100_bases
ATATAGTATACCTTTTATACAATTTTTAGATATAATAATCCAAGGTATGTTCCATATTTTCATTGATATGATATCTTTGT
AACTAGGTTCACAACTTTCT

Product: ATP-dependent helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 875; Mature: 874

Protein sequence:

>875_residues
MSSTYFYADEEIYNLLRPYVAKWFKEKYTTFTPPQRAAIPLIKQNYNVLVSSPTGSGKTLAAFLGILDSLFELGDNNELE
DKVYAVYISPLRALNNDMQRNLLEPLNELKQINPRLPDIRVRIRTSDTTPYEKQKMLKKPPHILITTPESFGISITSPKF
SQKLTDVKWVIVDEIHELANSKRGAYLSAMLELFRSLLAKKEFVRIGLSATVSPLEEVAQFLVGKGREYRIVDARFVKPI
DIKVISPVKDLVHSSESEVDKGIYKTILNEVKKHRTTLIFTNTRHATERVAYKLRKLAENEKVFDVDAIEAHHSSLSRDV
RLDVEDKLKKGILKVVVSSTSLELGIDIGYIDLVVLLSSPKSVSRLLQRIGRAGHHIRSISKGRVIVVDRDDLVECSVLA
KLARDRKIDNIHIPKNPLDVLSQIIVSASLISPIDREELYNILKRSYNFSDLNESEYSLVLRYLSGDFFGVELKNVYAKI
RLKEEKIIYPKKGSRLIFYTNSGTIPDEAMISVVTENNRYVGNLEEEFVEILSPGDIFVLSGRTYEFIGSKGSKVIVKEA
IGQRPTVPSWFSEMLPLAYESALEVGKFRREIAEMIKKGVTHTEIIQNISKQYEIDKHSSMSIYTYILEQYLFTNGKVPS
DNLILIEIYDDEEGIRNYIFHALYGRRALDALSRAFAYVLSEELNTDVKVSVTDNGFVLSVKRDISLDYDIKNLFEKVNP
DNVYEIVTNAIMRTEMLKRRFRHCAERSFMILRKYKGRETNLERRELNSEILLKAVREIENFPVIKETIREILEDHMDIM
RAKEILRKVADHEITVDVFGPTSIPSPFSHSIILKGHSDVVLAEDRRELMKKLHDRVIEFLRQKGVNIELEYTSV

Sequences:

>Translated_875_residues
MSSTYFYADEEIYNLLRPYVAKWFKEKYTTFTPPQRAAIPLIKQNYNVLVSSPTGSGKTLAAFLGILDSLFELGDNNELE
DKVYAVYISPLRALNNDMQRNLLEPLNELKQINPRLPDIRVRIRTSDTTPYEKQKMLKKPPHILITTPESFGISITSPKF
SQKLTDVKWVIVDEIHELANSKRGAYLSAMLELFRSLLAKKEFVRIGLSATVSPLEEVAQFLVGKGREYRIVDARFVKPI
DIKVISPVKDLVHSSESEVDKGIYKTILNEVKKHRTTLIFTNTRHATERVAYKLRKLAENEKVFDVDAIEAHHSSLSRDV
RLDVEDKLKKGILKVVVSSTSLELGIDIGYIDLVVLLSSPKSVSRLLQRIGRAGHHIRSISKGRVIVVDRDDLVECSVLA
KLARDRKIDNIHIPKNPLDVLSQIIVSASLISPIDREELYNILKRSYNFSDLNESEYSLVLRYLSGDFFGVELKNVYAKI
RLKEEKIIYPKKGSRLIFYTNSGTIPDEAMISVVTENNRYVGNLEEEFVEILSPGDIFVLSGRTYEFIGSKGSKVIVKEA
IGQRPTVPSWFSEMLPLAYESALEVGKFRREIAEMIKKGVTHTEIIQNISKQYEIDKHSSMSIYTYILEQYLFTNGKVPS
DNLILIEIYDDEEGIRNYIFHALYGRRALDALSRAFAYVLSEELNTDVKVSVTDNGFVLSVKRDISLDYDIKNLFEKVNP
DNVYEIVTNAIMRTEMLKRRFRHCAERSFMILRKYKGRETNLERRELNSEILLKAVREIENFPVIKETIREILEDHMDIM
RAKEILRKVADHEITVDVFGPTSIPSPFSHSIILKGHSDVVLAEDRRELMKKLHDRVIEFLRQKGVNIELEYTSV
>Mature_874_residues
SSTYFYADEEIYNLLRPYVAKWFKEKYTTFTPPQRAAIPLIKQNYNVLVSSPTGSGKTLAAFLGILDSLFELGDNNELED
KVYAVYISPLRALNNDMQRNLLEPLNELKQINPRLPDIRVRIRTSDTTPYEKQKMLKKPPHILITTPESFGISITSPKFS
QKLTDVKWVIVDEIHELANSKRGAYLSAMLELFRSLLAKKEFVRIGLSATVSPLEEVAQFLVGKGREYRIVDARFVKPID
IKVISPVKDLVHSSESEVDKGIYKTILNEVKKHRTTLIFTNTRHATERVAYKLRKLAENEKVFDVDAIEAHHSSLSRDVR
LDVEDKLKKGILKVVVSSTSLELGIDIGYIDLVVLLSSPKSVSRLLQRIGRAGHHIRSISKGRVIVVDRDDLVECSVLAK
LARDRKIDNIHIPKNPLDVLSQIIVSASLISPIDREELYNILKRSYNFSDLNESEYSLVLRYLSGDFFGVELKNVYAKIR
LKEEKIIYPKKGSRLIFYTNSGTIPDEAMISVVTENNRYVGNLEEEFVEILSPGDIFVLSGRTYEFIGSKGSKVIVKEAI
GQRPTVPSWFSEMLPLAYESALEVGKFRREIAEMIKKGVTHTEIIQNISKQYEIDKHSSMSIYTYILEQYLFTNGKVPSD
NLILIEIYDDEEGIRNYIFHALYGRRALDALSRAFAYVLSEELNTDVKVSVTDNGFVLSVKRDISLDYDIKNLFEKVNPD
NVYEIVTNAIMRTEMLKRRFRHCAERSFMILRKYKGRETNLERRELNSEILLKAVREIENFPVIKETIREILEDHMDIMR
AKEILRKVADHEITVDVFGPTSIPSPFSHSIILKGHSDVVLAEDRRELMKKLHDRVIEFLRQKGVNIELEYTSV

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI40217847, Length=409, Percent_Identity=23.4718826405868, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1787942, Length=903, Percent_Identity=32.6688815060908, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17537519, Length=346, Percent_Identity=23.9884393063584, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17537127, Length=378, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508543, Length=410, Percent_Identity=23.6585365853659, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI9755332, Length=406, Percent_Identity=28.3251231527094, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321710, Length=366, Percent_Identity=25.9562841530055, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321020, Length=430, Percent_Identity=25.3488372093023, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321856, Length=381, Percent_Identity=24.6719160104987, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647182, Length=387, Percent_Identity=27.1317829457364, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24584399, Length=356, Percent_Identity=24.1573033707865, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR017170 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 100411; Mature: 100280

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTYFYADEEIYNLLRPYVAKWFKEKYTTFTPPQRAAIPLIKQNYNVLVSSPTGSGKTL
CCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEECCCCCCHHH
AAFLGILDSLFELGDNNELEDKVYAVYISPLRALNNDMQRNLLEPLNELKQINPRLPDIR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VRIRTSDTTPYEKQKMLKKPPHILITTPESFGISITSPKFSQKLTDVKWVIVDEIHELAN
EEEEECCCCCHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHC
SKRGAYLSAMLELFRSLLAKKEFVRIGLSATVSPLEEVAQFLVGKGREYRIVDARFVKPI
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
DIKVISPVKDLVHSSESEVDKGIYKTILNEVKKHRTTLIFTNTRHATERVAYKLRKLAEN
CEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCC
EKVFDVDAIEAHHSSLSRDVRLDVEDKLKKGILKVVVSSTSLELGIDIGYIDLVVLLSSP
CCEEEEHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCC
KSVSRLLQRIGRAGHHIRSISKGRVIVVDRDDLVECSVLAKLARDRKIDNIHIPKNPLDV
HHHHHHHHHHHHCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
LSQIIVSASLISPIDREELYNILKRSYNFSDLNESEYSLVLRYLSGDFFGVELKNVYAKI
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHE
RLKEEKIIYPKKGSRLIFYTNSGTIPDEAMISVVTENNRYVGNLEEEFVEILSPGDIFVL
EECCCEEECCCCCCEEEEEECCCCCCCHHHEEEEECCCCEECCHHHHHHHHHCCCCEEEE
SGRTYEFIGSKGSKVIVKEAIGQRPTVPSWFSEMLPLAYESALEVGKFRREIAEMIKKGV
CCCEEEEECCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
THTEIIQNISKQYEIDKHSSMSIYTYILEQYLFTNGKVPSDNLILIEIYDDEEGIRNYIF
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHH
HALYGRRALDALSRAFAYVLSEELNTDVKVSVTDNGFVLSVKRDISLDYDIKNLFEKVNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCC
DNVYEIVTNAIMRTEMLKRRFRHCAERSFMILRKYKGRETNLERRELNSEILLKAVREIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHH
NFPVIKETIREILEDHMDIMRAKEILRKVADHEITVDVFGPTSIPSPFSHSIILKGHSDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCE
VLAEDRRELMKKLHDRVIEFLRQKGVNIELEYTSV
EEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure 
SSTYFYADEEIYNLLRPYVAKWFKEKYTTFTPPQRAAIPLIKQNYNVLVSSPTGSGKTL
CCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEECCCCCCHHH
AAFLGILDSLFELGDNNELEDKVYAVYISPLRALNNDMQRNLLEPLNELKQINPRLPDIR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VRIRTSDTTPYEKQKMLKKPPHILITTPESFGISITSPKFSQKLTDVKWVIVDEIHELAN
EEEEECCCCCHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHC
SKRGAYLSAMLELFRSLLAKKEFVRIGLSATVSPLEEVAQFLVGKGREYRIVDARFVKPI
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
DIKVISPVKDLVHSSESEVDKGIYKTILNEVKKHRTTLIFTNTRHATERVAYKLRKLAEN
CEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCC
EKVFDVDAIEAHHSSLSRDVRLDVEDKLKKGILKVVVSSTSLELGIDIGYIDLVVLLSSP
CCEEEEHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCCC
KSVSRLLQRIGRAGHHIRSISKGRVIVVDRDDLVECSVLAKLARDRKIDNIHIPKNPLDV
HHHHHHHHHHHHCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCHHHH
LSQIIVSASLISPIDREELYNILKRSYNFSDLNESEYSLVLRYLSGDFFGVELKNVYAKI
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHE
RLKEEKIIYPKKGSRLIFYTNSGTIPDEAMISVVTENNRYVGNLEEEFVEILSPGDIFVL
EECCCEEECCCCCCEEEEEECCCCCCCHHHEEEEECCCCEECCHHHHHHHHHCCCCEEEE
SGRTYEFIGSKGSKVIVKEAIGQRPTVPSWFSEMLPLAYESALEVGKFRREIAEMIKKGV
CCCEEEEECCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
THTEIIQNISKQYEIDKHSSMSIYTYILEQYLFTNGKVPSDNLILIEIYDDEEGIRNYIF
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHH
HALYGRRALDALSRAFAYVLSEELNTDVKVSVTDNGFVLSVKRDISLDYDIKNLFEKVNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCC
DNVYEIVTNAIMRTEMLKRRFRHCAERSFMILRKYKGRETNLERRELNSEILLKAVREIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHH
NFPVIKETIREILEDHMDIMRAKEILRKVADHEITVDVFGPTSIPSPFSHSIILKGHSDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEEECCCCE
VLAEDRRELMKKLHDRVIEFLRQKGVNIELEYTSV
EEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]