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The map label for this gene is psmB1

Identifier: 227828116

GI number: 227828116

Start: 1704071

End: 1704661

Strand: Direct

Name: psmB1

Synonym: M1425_1854

Alternate gene names: 227828116

Gene position: 1704071-1704661 (Clockwise)

Preceding gene: 227828115

Following gene: 227828118

Centisome position: 65.32

GC content: 35.7

Gene sequence:

>591_bases
ATGGAAGAATTGCCTGCAACTGCTATTGGTTTAAAGGTAAATGATGGAATTGTATTAGCTTCTGAAAGACGATTAAGCTA
TGGTGGTTATGTACTAAGTAAACAAGCGAAGAAAGTACATAAAATAGGTAAATTTCTCATGGCGGGGGCCGGAATATATG
GCGACTTACAGACTTTGACGAGAATAATGAATGTAGAAATAAAGTACTATGAGATTTCAACTGGTAAACCAATTTCTGTT
CACGCTGCAGCTAAATTACTTTCAGTAATACTATATCAGTATAAAGTAATGCCGTTCATTTCAGAGATTCTATTCGGTGG
AGTGGATGAAAAAGGACCACAACTTTATGTATTAGACCCTATAGGTTCATTAATTGAAGATAACTACGCTGCAGTGGGAT
CGGGAGCCAGGATCGCTATAGGAGTTCTTGAATCTGAATATGATCCTAATATGAATTTAGACATAGCAGCACAATTAATA
ACAAAGGCGATAAAAGCATCTATAGAACGTGATATCACATCTGGAGATGGAATAGATTTAGCGATAATGGATAAGAAAGG
AAACTATGAAAACAAATTCATCCCATACTAA

Upstream 100 bases:

>100_bases
TTACACGAAAACAGATTTCCGTTCCACTAGAGAACATTGAAGATGCAATAAAACAAACGTTATAAATGGCATTTAGAAGT
ATATTTATGGGTAAACTAAC

Downstream 100 bases:

>100_bases
GTATTTTTCTTCACACAGAAGTAAATATGATCCATAACATTTAATTGATGTGTTTTAAGAAAGCTTTCTTTATTGCTTAT
TATCTTTACTAGCAATCCAA

Product: proteasome endopeptidase complex

Products: NA

Alternate protein names: 20S proteasome beta subunit 1; Proteasome core protein PsmB 1

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLTRIMNVEIKYYEISTGKPISV
HAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLI
TKAIKASIERDITSGDGIDLAIMDKKGNYENKFIPY

Sequences:

>Translated_196_residues
MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLTRIMNVEIKYYEISTGKPISV
HAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLI
TKAIKASIERDITSGDGIDLAIMDKKGNYENKFIPY
>Mature_196_residues
MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLTRIMNVEIKYYEISTGKPISV
HAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDPIGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLI
TKAIKASIERDITSGDGIDLAIMDKKGNYENKFIPY

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506191, Length=182, Percent_Identity=34.0659340659341, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI73747875, Length=182, Percent_Identity=33.5164835164835, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI4758970, Length=183, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI4506203, Length=182, Percent_Identity=33.5164835164835, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4506201, Length=175, Percent_Identity=33.1428571428571, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4506193, Length=193, Percent_Identity=30.5699481865285, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI22538465, Length=181, Percent_Identity=26.5193370165746, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI153791216, Length=182, Percent_Identity=29.6703296703297, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI23110942, Length=195, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI195539356, Length=131, Percent_Identity=34.3511450381679, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI23110925, Length=183, Percent_Identity=25.1366120218579, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI222144262, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508495, Length=180, Percent_Identity=30, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17541700, Length=192, Percent_Identity=27.0833333333333, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508499, Length=167, Percent_Identity=34.7305389221557, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554384, Length=191, Percent_Identity=26.7015706806283, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535357, Length=174, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508493, Length=183, Percent_Identity=23.4972677595628, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324731, Length=179, Percent_Identity=30.7262569832402, Blast_Score=94, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6325360, Length=183, Percent_Identity=31.1475409836066, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321574, Length=199, Percent_Identity=27.1356783919598, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319430, Length=201, Percent_Identity=24.8756218905473, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320849, Length=184, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639979, Length=180, Percent_Identity=32.7777777777778, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664391, Length=183, Percent_Identity=30.0546448087432, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355573, Length=170, Percent_Identity=34.1176470588235, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24652553, Length=170, Percent_Identity=34.1176470588235, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28573221, Length=179, Percent_Identity=24.0223463687151, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24584895, Length=187, Percent_Identity=29.9465240641711, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20130281, Length=171, Percent_Identity=26.9005847953216, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24654391, Length=198, Percent_Identity=26.7676767676768, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654389, Length=198, Percent_Identity=26.7676767676768, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737605, Length=187, Percent_Identity=28.8770053475936, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653999, Length=182, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581176, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB1_SULIN (C3NFX2)

Other databases:

- EMBL:   CP001404
- RefSeq:   YP_002840012.1
- GeneID:   7809592
- GenomeReviews:   CP001404_GR
- KEGG:   sin:YN1551_0982
- OMA:   EKRVSYG
- ProtClustDB:   CLSK883626
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 21350; Mature: 21350

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 7-7

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLT
CCCCCCEEEEEEECCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RIMNVEIKYYEISTGKPISVHAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDP
HHHCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
IGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLITKAIKASIERDITSGDGIDL
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AIMDKKGNYENKFIPY
EEEECCCCCCCCCCCC
>Mature Secondary Structure
MEELPATAIGLKVNDGIVLASERRLSYGGYVLSKQAKKVHKIGKFLMAGAGIYGDLQTLT
CCCCCCEEEEEEECCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RIMNVEIKYYEISTGKPISVHAAAKLLSVILYQYKVMPFISEILFGGVDEKGPQLYVLDP
HHHCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
IGSLIEDNYAAVGSGARIAIGVLESEYDPNMNLDIAAQLITKAIKASIERDITSGDGIDL
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AIMDKKGNYENKFIPY
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA