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The map label for this gene is eif6

Identifier: 227828019

GI number: 227828019

Start: 1626402

End: 1627073

Strand: Direct

Name: eif6

Synonym: M1425_1755

Alternate gene names: 227828019

Gene position: 1626402-1627073 (Clockwise)

Preceding gene: 227828018

Following gene: 227828020

Centisome position: 62.34

GC content: 33.78

Gene sequence:

>672_bases
ATGAATCTGCAAAGGTTATCAATTTTTGGAACAGATAATATAGGGGTCTATATTTATACTAATAATAAATATACAGTAGT
TCCTAGAGGATTAGATAGTGAAACAAAAGAAAATATTGTTCAAATATTAGGAACTGAGTTAATAGAAGCGGAGATATCCA
GAAGTTTTCTTTTAGGTATTTTTATAAGTGGTAATGATAACGGCATTCTTTTACCTAAATCCACAATTGATGATGAGTTC
AGATTTCTGAAGGAGAATCTTAGGGACTGCAGAGTTGAGGTTCTTAATTCAAAAGTAACCGCGTTGGGAAACACAATACT
CACAAATAATAAGGCAGCATTAATTTATCCTGAATTTAATGATATTGAAGAAAAGATAATAAAAGAGACCTTAGGCGTTG
AAGAGATAAGAAGAGGAAAAATAGCCCAAATGATAACCGTAGGTTCTGTAGGAGTTGTAACAAATAAAGGCGGATTAGTA
CATGTAGATACAAGTGAGAAAGAACTAAAAGAACTGGAAAAATTATTCGGCGTAAAGATAGATATAGGCACGGTAAATTT
TGGAAGCGTCTTCATTAGGAGTGGACTAGTCGCAAACGATAAAGGAACGTTAGTAGGCGCGTCAACTACGGGTCCAGAGA
TTTTAAGAATTCAAAAAGCATTAGGTGAATGA

Upstream 100 bases:

>100_bases
TATCTAAAAACGGAAATGATAAGGTAGTTAGTAAAGTTAGAGTAGTAGTTAGTAAGGTAGGAGAAAAAATATATCTTGTA
AGACTTGCTATTAAAAGTAG

Downstream 100 bases:

>100_bases
GATGAGTGAAATAAAGTTTTACCTTGTCAAAGGATCTGCCCTATTTGGAGAGTCCCACTATCCAGAGAAGAGAAAATTTG
TAAAAATAGTTAGAGCACTG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFNDIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE

Sequences:

>Translated_223_residues
MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFNDIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE
>Mature_223_residues
MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFNDIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=217, Percent_Identity=32.7188940092166, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI31563378, Length=217, Percent_Identity=32.7188940092166, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI31563374, Length=91, Percent_Identity=41.7582417582418, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17506075, Length=217, Percent_Identity=29.4930875576037, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325273, Length=232, Percent_Identity=33.6206896551724, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21492634, Length=219, Percent_Identity=36.0730593607306, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_SULIA (C3MZB3)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002843790.1
- GeneID:   7812214
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_1873
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 24474; Mature: 24474

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGI
CCCEEEEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FISGNDNGILLPKSTIDDEFRFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFN
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCEEEECCCEEEEECCCC
DIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLVHVDTSEKELKELEKLFGVKI
HHHHHHHHHHCCHHHHHCCCCEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHCCEE
DIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE
EEECCCHHHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLQRLSIFGTDNIGVYIYTNNKYTVVPRGLDSETKENIVQILGTELIEAEISRSFLLGI
CCCEEEEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FISGNDNGILLPKSTIDDEFRFLKENLRDCRVEVLNSKVTALGNTILTNNKAALIYPEFN
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCEEEECCCEEEEECCCC
DIEEKIIKETLGVEEIRRGKIAQMITVGSVGVVTNKGGLVHVDTSEKELKELEKLFGVKI
HHHHHHHHHHCCHHHHHCCCCEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHCCEE
DIGTVNFGSVFIRSGLVANDKGTLVGASTTGPEILRIQKALGE
EEECCCHHHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA