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The map label for this gene is glmS [H]

Identifier: 227827987

GI number: 227827987

Start: 1599818

End: 1601593

Strand: Direct

Name: glmS [H]

Synonym: M1425_1723

Alternate gene names: 227827987

Gene position: 1599818-1601593 (Clockwise)

Preceding gene: 227827986

Following gene: 227827988

Centisome position: 61.32

GC content: 37.95

Gene sequence:

>1776_bases
GTGTGTGGAATTATAGGGGTTGTTTCGAATAAGGAAAGCAAGAGACTAGCTGAATTAGTAGTGTCATGCCTTAATAGACT
AGAATACAGGGGTTATGATAGTGTTGGCGTTGCTGCACTTTCAAGTGCTAATTTAGAGGTAAGAAAGGCTAAGGGTACTG
TTGAGGAAGTAGTAAGGAAGAAGAATATTAAAGAGTTGTCTGGTTACGCGTTTTTAGGACATACCAGATGGGCTACTCAT
GGAGCCCCTACTGACTATAATGCTCATCCACATACAGATTGTAGTAATAATATAGCGGTAATTCATAATGGAACAATAAG
GAATTTTAAAGAGCTAAGAGATGAGTTACAGTCCCTAGGCCATAAGTTCAAGAGTGAGACTGACACTGAGGTAATACCCC
ATATGATGGAGGAATACATGAAAAGGGGTATGGATACTTTTCAAGCTTTTAGAAGTGCAGTAAAAAGCATTCAAGGTAGC
TTTGCGATTTTGGCAGTAGTTAAGGGAGAGAGGAGAATTTTCTTCGCAAAGAGAGATAACCCATTAGTAATAGGATTAGG
AGACGATAAGACGTTTATAGCTAGTGATATTCCTTCATTTCTACCTTACACCAGAAAGGTTATAGTAATATCTGATGGAG
AGCTAGGCTATGTAACGCCGAATACTGTTTATATAGAAGACGAAAACGATAATCCAATAGATGTCACAAGTAGGATAAAG
ATTATAGATTGGGACGCATCCTCAGCCTCTAAAGAAGGATATCCTCACTTTATGCTTAAGGAAATTCATGAAAGTCCAAT
TGCTGTTAAAGATACGATCTCTGGACTTTTAAGTGAAATTGATAAGGTAAGTGAAATCGCTGAGGAAATAAGGGAGTCCT
CTAGAATAATAGTCACAGCTGCTGGAACAAGTTATCATGCTGGATTTTATTTCTCATTATTACTTGCTAGAAAAGGATAT
ACGAGTATTCCATTAATTGCCTCAGAATATCATAATTTTAGAGTTAAAAAAGGTGATATTGTAATTGCGATAAGTCAAAG
TGGAGAAACTCTAGACGTCAAAATGGGTATTAGGAAATTCAAAGAGGAAGGGGCTAAGATAATTGCATTAACGAACGTAA
TTGAGAGCGACATAGCTAGGGAAAGCGATTACAAACTATATATGAGAGCTGGACCAGAAATAGGAGTGGCGGCTACGAAA
ACTTTCACATCTGAAATTGCATCCTTACTCTTCTTGTATTCTCTAATAGAAAAGGAAAGCATCTCTTATCTAGAAAGCGC
TCACGAGACAGTTAGAAATGTAATAACTGAGACGGAAGGATTTGCTAAGAAGATTGGGGAGGAGTTGGCTAACAAGAACA
ACGCCTATTACTTGGGAAGAGGTCTAGGAGTACCTTTAGCAATGGAAGGAGCATTAAAGATAAAGGAAATAGCGTACATC
CACGCTGAAGCGTATCCAGCTGGAGAAAGTAAACATGGACCGATAGCGTTAGTTGAGAATGGATTTCCAATAGTCTTCAT
AAACGATGGAGAACTGGTAGATGAATTGGAGAAGAATTTACAAGAGATGAAAGCGAGAGGTGGTAAGACTTATTCAATAA
GTGTGAATAAGAGACTTAACTTCGCAGATACTGAGATTCTAGTAAATACTGATGAAAAACTCTCTTCACTTGCAATAGCG
CCAATAATTCAACTAATAGCATATTACGCTTCTGTTAAAAGAGGATACGATCCAGATAAGCCTAGAAACCTGGCCAAAAC
AGTAACGGTTGAGTAA

Upstream 100 bases:

>100_bases
AACGCTAGGATAGTTAATTCAACTCTAATCAAAGATGGTGTCGATATTTCGATAATATGAGGAAAAGTCTAATTTACCAG
TAACTAGAAGATAGATTATT

Downstream 100 bases:

>100_bases
AGATGAAAGCTATAGTGTTAGCTGGAGGAAAGGGAGAAGGATTATTGCCATACACTGACAAGGTTCAGAAAGAGGCTATC
ACAGTACTAGGCAAAGCAAT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MCGIIGVVSNKESKRLAELVVSCLNRLEYRGYDSVGVAALSSANLEVRKAKGTVEEVVRKKNIKELSGYAFLGHTRWATH
GAPTDYNAHPHTDCSNNIAVIHNGTIRNFKELRDELQSLGHKFKSETDTEVIPHMMEEYMKRGMDTFQAFRSAVKSIQGS
FAILAVVKGERRIFFAKRDNPLVIGLGDDKTFIASDIPSFLPYTRKVIVISDGELGYVTPNTVYIEDENDNPIDVTSRIK
IIDWDASSASKEGYPHFMLKEIHESPIAVKDTISGLLSEIDKVSEIAEEIRESSRIIVTAAGTSYHAGFYFSLLLARKGY
TSIPLIASEYHNFRVKKGDIVIAISQSGETLDVKMGIRKFKEEGAKIIALTNVIESDIARESDYKLYMRAGPEIGVAATK
TFTSEIASLLFLYSLIEKESISYLESAHETVRNVITETEGFAKKIGEELANKNNAYYLGRGLGVPLAMEGALKIKEIAYI
HAEAYPAGESKHGPIALVENGFPIVFINDGELVDELEKNLQEMKARGGKTYSISVNKRLNFADTEILVNTDEKLSSLAIA
PIIQLIAYYASVKRGYDPDKPRNLAKTVTVE

Sequences:

>Translated_591_residues
MCGIIGVVSNKESKRLAELVVSCLNRLEYRGYDSVGVAALSSANLEVRKAKGTVEEVVRKKNIKELSGYAFLGHTRWATH
GAPTDYNAHPHTDCSNNIAVIHNGTIRNFKELRDELQSLGHKFKSETDTEVIPHMMEEYMKRGMDTFQAFRSAVKSIQGS
FAILAVVKGERRIFFAKRDNPLVIGLGDDKTFIASDIPSFLPYTRKVIVISDGELGYVTPNTVYIEDENDNPIDVTSRIK
IIDWDASSASKEGYPHFMLKEIHESPIAVKDTISGLLSEIDKVSEIAEEIRESSRIIVTAAGTSYHAGFYFSLLLARKGY
TSIPLIASEYHNFRVKKGDIVIAISQSGETLDVKMGIRKFKEEGAKIIALTNVIESDIARESDYKLYMRAGPEIGVAATK
TFTSEIASLLFLYSLIEKESISYLESAHETVRNVITETEGFAKKIGEELANKNNAYYLGRGLGVPLAMEGALKIKEIAYI
HAEAYPAGESKHGPIALVENGFPIVFINDGELVDELEKNLQEMKARGGKTYSISVNKRLNFADTEILVNTDEKLSSLAIA
PIIQLIAYYASVKRGYDPDKPRNLAKTVTVE
>Mature_591_residues
MCGIIGVVSNKESKRLAELVVSCLNRLEYRGYDSVGVAALSSANLEVRKAKGTVEEVVRKKNIKELSGYAFLGHTRWATH
GAPTDYNAHPHTDCSNNIAVIHNGTIRNFKELRDELQSLGHKFKSETDTEVIPHMMEEYMKRGMDTFQAFRSAVKSIQGS
FAILAVVKGERRIFFAKRDNPLVIGLGDDKTFIASDIPSFLPYTRKVIVISDGELGYVTPNTVYIEDENDNPIDVTSRIK
IIDWDASSASKEGYPHFMLKEIHESPIAVKDTISGLLSEIDKVSEIAEEIRESSRIIVTAAGTSYHAGFYFSLLLARKGY
TSIPLIASEYHNFRVKKGDIVIAISQSGETLDVKMGIRKFKEEGAKIIALTNVIESDIARESDYKLYMRAGPEIGVAATK
TFTSEIASLLFLYSLIEKESISYLESAHETVRNVITETEGFAKKIGEELANKNNAYYLGRGLGVPLAMEGALKIKEIAYI
HAEAYPAGESKHGPIALVENGFPIVFINDGELVDELEKNLQEMKARGGKTYSISVNKRLNFADTEILVNTDEKLSSLAIA
PIIQLIAYYASVKRGYDPDKPRNLAKTVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=31.8840579710145, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=31.9241982507289, Blast_Score=298, Evalue=8e-81,
Organism=Escherichia coli, GI1790167, Length=630, Percent_Identity=37.3015873015873, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788651, Length=202, Percent_Identity=26.7326732673267, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=31.2354312354312, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=30.4651162790698, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=30.4651162790698, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17554892, Length=233, Percent_Identity=26.1802575107296, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=457, Percent_Identity=31.0722100656455, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=24.4186046511628, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=31.7073170731707, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323958, Length=203, Percent_Identity=24.1379310344828, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=31.0595065312046, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65502; Mature: 65502

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGVVSNKESKRLAELVVSCLNRLEYRGYDSVGVAALSSANLEVRKAKGTVEEVVRK
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHH
KNIKELSGYAFLGHTRWATHGAPTDYNAHPHTDCSNNIAVIHNGTIRNFKELRDELQSLG
CCHHHHCCEEEECCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
HKFKSETDTEVIPHMMEEYMKRGMDTFQAFRSAVKSIQGSFAILAVVKGERRIFFAKRDN
HHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEEECCC
PLVIGLGDDKTFIASDIPSFLPYTRKVIVISDGELGYVTPNTVYIEDENDNPIDVTSRIK
CEEEEECCCCCCHHHCCHHHCCCCEEEEEEECCCEEEECCCEEEEECCCCCCEEEEEEEE
IIDWDASSASKEGYPHFMLKEIHESPIAVKDTISGLLSEIDKVSEIAEEIRESSRIIVTA
EEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGTSYHAGFYFSLLLARKGYTSIPLIASEYHNFRVKKGDIVIAISQSGETLDVKMGIRKF
CCCCCCHHHHHHHHHHHCCCCCCCEEHHCCCCEEEECCCEEEEECCCCCEEEHHHHHHHH
KEEGAKIIALTNVIESDIARESDYKLYMRAGPEIGVAATKTFTSEIASLLFLYSLIEKES
HHCCCEEEEEHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ISYLESAHETVRNVITETEGFAKKIGEELANKNNAYYLGRGLGVPLAMEGALKIKEIAYI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCEEEEHEEEE
HAEAYPAGESKHGPIALVENGFPIVFINDGELVDELEKNLQEMKARGGKTYSISVNKRLN
EEECCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FADTEILVNTDEKLSSLAIAPIIQLIAYYASVKRGYDPDKPRNLAKTVTVE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MCGIIGVVSNKESKRLAELVVSCLNRLEYRGYDSVGVAALSSANLEVRKAKGTVEEVVRK
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHH
KNIKELSGYAFLGHTRWATHGAPTDYNAHPHTDCSNNIAVIHNGTIRNFKELRDELQSLG
CCHHHHCCEEEECCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHH
HKFKSETDTEVIPHMMEEYMKRGMDTFQAFRSAVKSIQGSFAILAVVKGERRIFFAKRDN
HHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEEECCC
PLVIGLGDDKTFIASDIPSFLPYTRKVIVISDGELGYVTPNTVYIEDENDNPIDVTSRIK
CEEEEECCCCCCHHHCCHHHCCCCEEEEEEECCCEEEECCCEEEEECCCCCCEEEEEEEE
IIDWDASSASKEGYPHFMLKEIHESPIAVKDTISGLLSEIDKVSEIAEEIRESSRIIVTA
EEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGTSYHAGFYFSLLLARKGYTSIPLIASEYHNFRVKKGDIVIAISQSGETLDVKMGIRKF
CCCCCCHHHHHHHHHHHCCCCCCCEEHHCCCCEEEECCCEEEEECCCCCEEEHHHHHHHH
KEEGAKIIALTNVIESDIARESDYKLYMRAGPEIGVAATKTFTSEIASLLFLYSLIEKES
HHCCCEEEEEHHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ISYLESAHETVRNVITETEGFAKKIGEELANKNNAYYLGRGLGVPLAMEGALKIKEIAYI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCEEEEHEEEE
HAEAYPAGESKHGPIALVENGFPIVFINDGELVDELEKNLQEMKARGGKTYSISVNKRLN
EEECCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FADTEILVNTDEKLSSLAIAPIIQLIAYYASVKRGYDPDKPRNLAKTVTVE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA