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The map label for this gene is mvk [H]

Identifier: 227827986

GI number: 227827986

Start: 1598833

End: 1599777

Strand: Direct

Name: mvk [H]

Synonym: M1425_1722

Alternate gene names: 227827986

Gene position: 1598833-1599777 (Clockwise)

Preceding gene: 227827985

Following gene: 227827987

Centisome position: 61.29

GC content: 35.77

Gene sequence:

>945_bases
ATGAGAGTAGAAGCTAAGGTTCCGTTAAAGCTAACATTATTTGGAGAACACGCTGTAGTTTATGATAGACCGGCCATCGC
AATGACTATTTCAGAGAGCCTAAAGGTTAGGGTAAGTGAGAGTGACAGATTCCTAATTATATCACCGTCCCTCAATATAA
GAGGGGTTAAGTTAGATCTAAATGAGATGAAAATTGAGAGTGATGAGGCGAAGAAAGTACTTAGGTATGTATTTGAAGTA
TTGAATTACTTTGAAATGAAGAAGCCAGTTAAAATAGAAATAGACTCCACAGTTGAACCATCTGTTGGATTAGGTACAAG
TGCTGCAGTTATTGTTGGTACTGTTGCTGCTTATTCTAAATATTTGGGAATCGATTTAAACAGAGACGAAATAGCCAAAA
TTTCCCACGACATAGAGTTAAAGGTTCAAGGAATAGCAAGTAGGATGGATACTTATACTGAAACCTATGGTGGTTTGATT
TATTTCCTGCCCGGAGGAGAGGGATTTGAAAGGATAGATACTAATTTTGAACTAACAGCTGGTTACATAAGGAGAAGTAT
GAGTACTGCTGATGTATTATGGCGTGTTAGAAAACTTAAGGAGTTAAACAAGGAAGTCTTCGATAATATATTGGATGTAA
TAGGTGAGATAACTAATAGAGCTAAATCCTTAATAATTGAACAAAATTACGAGGAATTAGGACTCTTAATGTACGTAAAT
CATGGATTATTATTTTCATTAGGAATAACTTCTCCAGAAGCTGATGAGATTGTTTCTAGAGCTAAACAATTGAGAATAAA
AGGTTGTAAGATTAGTGGGGGAGGGGCTGGAGGTTCCATAATATGTATAAAGTCCGTTGAGGCTGAAGTTCTTTTAAAGA
GCTACAACGCTAGGATAGTTAATTCAACTCTAATCAAAGATGGTGTCGATATTTCGATAATATGA

Upstream 100 bases:

>100_bases
AGATGTGACCTAAATAAAATGAGGAAGGTCCCTTAACGAGAGGAAGTAAGTCTAAAAGACGTAAATGAACTTTTTATTTT
AAATTCAGATTTTTCATGGG

Downstream 100 bases:

>100_bases
GGAAAAGTCTAATTTACCAGTAACTAGAAGATAGATTATTGTGTGTGGAATTATAGGGGTTGTTTCGAATAAGGAAAGCA
AGAGACTAGCTGAATTAGTA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVRVSESDRFLIISPSLNIRGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEIDSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLNRDEIAKISHDIELKVQGIASRMDTYTETYGGLI
YFLPGGEGFERIDTNFELTAGYIRRSMSTADVLWRVRKLKELNKEVFDNILDVIGEITNRAKSLIIEQNYEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLRIKGCKISGGGAGGSIICIKSVEAEVLLKSYNARIVNSTLIKDGVDISII

Sequences:

>Translated_314_residues
MRVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVRVSESDRFLIISPSLNIRGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEIDSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLNRDEIAKISHDIELKVQGIASRMDTYTETYGGLI
YFLPGGEGFERIDTNFELTAGYIRRSMSTADVLWRVRKLKELNKEVFDNILDVIGEITNRAKSLIIEQNYEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLRIKGCKISGGGAGGSIICIKSVEAEVLLKSYNARIVNSTLIKDGVDISII
>Mature_314_residues
MRVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVRVSESDRFLIISPSLNIRGVKLDLNEMKIESDEAKKVLRYVFEV
LNYFEMKKPVKIEIDSTVEPSVGLGTSAAVIVGTVAAYSKYLGIDLNRDEIAKISHDIELKVQGIASRMDTYTETYGGLI
YFLPGGEGFERIDTNFELTAGYIRRSMSTADVLWRVRKLKELNKEVFDNILDVIGEITNRAKSLIIEQNYEELGLLMYVN
HGLLFSLGITSPEADEIVSRAKQLRIKGCKISGGGAGGSIICIKSVEAEVLLKSYNARIVNSTLIKDGVDISII

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323864, Length=349, Percent_Identity=26.647564469914, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34845; Mature: 34845

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVRVSESDRFLIISPSLNIRGVKLDL
CCCCCCCCEEEEEECCEEEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCEEEEEEEH
NEMKIESDEAKKVLRYVFEVLNYFEMKKPVKIEIDSTVEPSVGLGTSAAVIVGTVAAYSK
HHEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YLGIDLNRDEIAKISHDIELKVQGIASRMDTYTETYGGLIYFLPGGEGFERIDTNFELTA
HHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCEEEH
GYIRRSMSTADVLWRVRKLKELNKEVFDNILDVIGEITNRAKSLIIEQNYEELGLLMYVN
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHCCEEEEEC
HGLLFSLGITSPEADEIVSRAKQLRIKGCKISGGGAGGSIICIKSVEAEVLLKSYNARIV
CCEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCEEE
NSTLIKDGVDISII
EHHHHCCCCEEEEC
>Mature Secondary Structure
MRVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVRVSESDRFLIISPSLNIRGVKLDL
CCCCCCCCEEEEEECCEEEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCEEEEEEEH
NEMKIESDEAKKVLRYVFEVLNYFEMKKPVKIEIDSTVEPSVGLGTSAAVIVGTVAAYSK
HHEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YLGIDLNRDEIAKISHDIELKVQGIASRMDTYTETYGGLIYFLPGGEGFERIDTNFELTA
HHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCCCEEEH
GYIRRSMSTADVLWRVRKLKELNKEVFDNILDVIGEITNRAKSLIIEQNYEELGLLMYVN
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHCCEEEEEC
HGLLFSLGITSPEADEIVSRAKQLRIKGCKISGGGAGGSIICIKSVEAEVLLKSYNARIV
CCEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCEEE
NSTLIKDGVDISII
EHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA