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The map label for this gene is 227827984

Identifier: 227827984

GI number: 227827984

Start: 1595893

End: 1597452

Strand: Direct

Name: 227827984

Synonym: M1425_1720

Alternate gene names: NA

Gene position: 1595893-1597452 (Clockwise)

Preceding gene: 227827983

Following gene: 227827985

Centisome position: 61.17

GC content: 37.82

Gene sequence:

>1560_bases
TTGACATCTTCTTCTTTTATCTCTACTTGGTTATGTTTTTGTTCTTCCCTAGTTTCTCCTCCAAATATAACAATTGCCTC
ATTGCCCATGACGTTTGTTTTCGTAACAGTGGGATTTTCAATTACTATATTCTTTTCATTAGTCTCAATTATCACTCTAA
TTGCGTTTATTTGTTCAGTTTTTATTCCCATTCTTTCCATTTTCTTTAGGTCTGAGGGTTTAATTTTTGTCATAACAAGT
TTTATTGAAGAAGAAGTAAACTTAATAGTTTGCGGTTACAATATTTCACAAATGAATTACTTTCTGAAAATATTAGGTGG
AGGAAGAGAGGTAGGCAGGTCTGCTATTGAGGTCGGAAATAGCGACAGCAGTATCATACTAGATTATGGAGTGAACTTTG
ATGAAAAGGATAATCCAAATTTTCCATTGCAGGAAGTGCCTAATAGAGTAAAGGGCTTTGTCGTATCTCATGCACACCTA
GACCATGTAGGAGCTTTGCCAATCTATCAAATAGGCTCATTGAATACTAAGGTCTACGGCACTGTGGCAACTAGGATAAT
AACTGAGGTTATGTTAAAGGACTTCCTAAAGCTTTCCGGTTCTAAAATACCTTACGAGTGGGTTGAGGTAAGGAAGACCA
TGGACAATTTCATGGCGATTGGATATGGGGAAGAGATGGAAATTGATAGTATGAAAGTCTCACTATATAATGCCGGCCAC
ATACCTGGAAGTTCCATTATTAAGGTATCATCAGAGAAAGGCGCAGTAGCATTTACCGGAGACATTAACTTAACTGAGAC
TAAATTGATGAAACCAGCAGAAATTGAGAGTATAGGGAATGCAAACGTTCTAGTCATGGAGTCGACTTATGGTAAATTTA
ACCATCCTAATAGGAAAGACGTTGAGAACGAGTTCTACGAGAAGGTTTTAGAAGTCGTTGAGAGTGGTGGGACTGTCTTA
GTACCGGCTTTTAGTTTAGCGAGAAGCCAAGAAGTGTTGTCTGTATTGGCGGAAAGGGATTTCCCTTATCCAGTTTACTA
TGATGGAATGTCTAGAGAGATAACGGAGATAATGCTTGGTTTTAGGGAGTTTTTAAATAAACCAGATTTACTTAAGAAGG
CTTACGATAATTTCAATTACGTTAAGGGATGGGAGGATAGACATAGAGCATGGAAGGAGAGAGGAGTTATCGTTGCCAGT
GCGGGAATGCTTAAGGGTGGACCAGCTGTTTATTACTTCAAAAAGCTTTCAGAAAATAGTAAGAATGCAATATTCTTAGT
TAGTTATCAAGCTATTAACACACCGGGGAGGAGGTTATTGGAAATGGGTAAGTTCGATGAGTATTCTGGGTTATTAAGGG
CTAGATTGGAGATCTTTGACTTTTCAAGTCATGCTGGGAGAAGACAACTTCTAGAGATAGTCAAATCGATTAAGGGTTTG
GAAAAGGTAGTACTAGTTCACGGTTCTCCAGATAACGAAACGTCATTGGCTGATTTAATAAAGCAAGAGACTGGAGTTGA
AGTAATAATTCCGGAAAATGGTCAAGAAATTAGTTTATAA

Upstream 100 bases:

>100_bases
TCCTTGCAGAATCATAATTGCCTTTGCTATATCACCATTTGCCTTAATTAAGGCCTCTCTCGCTTCCTTTTCGCTTTTAC
CAGTTTGCTCGGCGACGAAT

Downstream 100 bases:

>100_bases
ACGTTTGAAGTAGACGTAATTTGTGATAATACTATTTATTCACGCGTCGGACTTCTCGTTTAATGTAAAGGAAAAAGCCA
TTAAGGAACCAGAAGAGGCT

Product: beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTSSSFISTWLCFCSSLVSPPNITIASLPMTFVFVTVGFSITIFFSLVSIITLIAFICSVFIPILSIFFRSEGLIFVITS
FIEEEVNLIVCGYNISQMNYFLKILGGGREVGRSAIEVGNSDSSIILDYGVNFDEKDNPNFPLQEVPNRVKGFVVSHAHL
DHVGALPIYQIGSLNTKVYGTVATRIITEVMLKDFLKLSGSKIPYEWVEVRKTMDNFMAIGYGEEMEIDSMKVSLYNAGH
IPGSSIIKVSSEKGAVAFTGDINLTETKLMKPAEIESIGNANVLVMESTYGKFNHPNRKDVENEFYEKVLEVVESGGTVL
VPAFSLARSQEVLSVLAERDFPYPVYYDGMSREITEIMLGFREFLNKPDLLKKAYDNFNYVKGWEDRHRAWKERGVIVAS
AGMLKGGPAVYYFKKLSENSKNAIFLVSYQAINTPGRRLLEMGKFDEYSGLLRARLEIFDFSSHAGRRQLLEIVKSIKGL
EKVVLVHGSPDNETSLADLIKQETGVEVIIPENGQEISL

Sequences:

>Translated_519_residues
MTSSSFISTWLCFCSSLVSPPNITIASLPMTFVFVTVGFSITIFFSLVSIITLIAFICSVFIPILSIFFRSEGLIFVITS
FIEEEVNLIVCGYNISQMNYFLKILGGGREVGRSAIEVGNSDSSIILDYGVNFDEKDNPNFPLQEVPNRVKGFVVSHAHL
DHVGALPIYQIGSLNTKVYGTVATRIITEVMLKDFLKLSGSKIPYEWVEVRKTMDNFMAIGYGEEMEIDSMKVSLYNAGH
IPGSSIIKVSSEKGAVAFTGDINLTETKLMKPAEIESIGNANVLVMESTYGKFNHPNRKDVENEFYEKVLEVVESGGTVL
VPAFSLARSQEVLSVLAERDFPYPVYYDGMSREITEIMLGFREFLNKPDLLKKAYDNFNYVKGWEDRHRAWKERGVIVAS
AGMLKGGPAVYYFKKLSENSKNAIFLVSYQAINTPGRRLLEMGKFDEYSGLLRARLEIFDFSSHAGRRQLLEIVKSIKGL
EKVVLVHGSPDNETSLADLIKQETGVEVIIPENGQEISL
>Mature_518_residues
TSSSFISTWLCFCSSLVSPPNITIASLPMTFVFVTVGFSITIFFSLVSIITLIAFICSVFIPILSIFFRSEGLIFVITSF
IEEEVNLIVCGYNISQMNYFLKILGGGREVGRSAIEVGNSDSSIILDYGVNFDEKDNPNFPLQEVPNRVKGFVVSHAHLD
HVGALPIYQIGSLNTKVYGTVATRIITEVMLKDFLKLSGSKIPYEWVEVRKTMDNFMAIGYGEEMEIDSMKVSLYNAGHI
PGSSIIKVSSEKGAVAFTGDINLTETKLMKPAEIESIGNANVLVMESTYGKFNHPNRKDVENEFYEKVLEVVESGGTVLV
PAFSLARSQEVLSVLAERDFPYPVYYDGMSREITEIMLGFREFLNKPDLLKKAYDNFNYVKGWEDRHRAWKERGVIVASA
GMLKGGPAVYYFKKLSENSKNAIFLVSYQAINTPGRRLLEMGKFDEYSGLLRARLEIFDFSSHAGRRQLLEIVKSIKGLE
KVVLVHGSPDNETSLADLIKQETGVEVIIPENGQEISL

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=443, Percent_Identity=27.9909706546275, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI7706427, Length=459, Percent_Identity=27.4509803921569, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32564696, Length=437, Percent_Identity=26.0869565217391, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32566029, Length=446, Percent_Identity=27.8026905829596, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323307, Length=472, Percent_Identity=24.7881355932203, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21358523, Length=438, Percent_Identity=27.8538812785388, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24648013, Length=449, Percent_Identity=27.6169265033408, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 57908; Mature: 57777

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSFISTWLCFCSSLVSPPNITIASLPMTFVFVTVGFSITIFFSLVSIITLIAFICSV
CCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIPILSIFFRSEGLIFVITSFIEEEVNLIVCGYNISQMNYFLKILGGGREVGRSAIEVGN
HHHHHHHHHCCCCCEEEHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCHHHCHHHHHCCC
SDSSIILDYGVNFDEKDNPNFPLQEVPNRVKGFVVSHAHLDHVGALPIYQIGSLNTKVYG
CCCCEEEEECCCCCCCCCCCCCHHHCCHHHHHEEEECCHHCCCCCCCCEEECCCCCEEHH
TVATRIITEVMLKDFLKLSGSKIPYEWVEVRKTMDNFMAIGYGEEMEIDSMKVSLYNAGH
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEECCCCCCEECCEEEEEEECCC
IPGSSIIKVSSEKGAVAFTGDINLTETKLMKPAEIESIGNANVLVMESTYGKFNHPNRKD
CCCCCEEEEECCCCCEEEECCCCCCHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCH
VENEFYEKVLEVVESGGTVLVPAFSLARSQEVLSVLAERDFPYPVYYDGMSREITEIMLG
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
FREFLNKPDLLKKAYDNFNYVKGWEDRHRAWKERGVIVASAGMLKGGPAVYYFKKLSENS
HHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCEEEEHHHCCCC
KNAIFLVSYQAINTPGRRLLEMGKFDEYSGLLRARLEIFDFSSHAGRRQLLEIVKSIKGL
CCEEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCC
EKVVLVHGSPDNETSLADLIKQETGVEVIIPENGQEISL
EEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TSSSFISTWLCFCSSLVSPPNITIASLPMTFVFVTVGFSITIFFSLVSIITLIAFICSV
CCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIPILSIFFRSEGLIFVITSFIEEEVNLIVCGYNISQMNYFLKILGGGREVGRSAIEVGN
HHHHHHHHHCCCCCEEEHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCHHHCHHHHHCCC
SDSSIILDYGVNFDEKDNPNFPLQEVPNRVKGFVVSHAHLDHVGALPIYQIGSLNTKVYG
CCCCEEEEECCCCCCCCCCCCCHHHCCHHHHHEEEECCHHCCCCCCCCEEECCCCCEEHH
TVATRIITEVMLKDFLKLSGSKIPYEWVEVRKTMDNFMAIGYGEEMEIDSMKVSLYNAGH
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEECCCCCCEECCEEEEEEECCC
IPGSSIIKVSSEKGAVAFTGDINLTETKLMKPAEIESIGNANVLVMESTYGKFNHPNRKD
CCCCCEEEEECCCCCEEEECCCCCCHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCH
VENEFYEKVLEVVESGGTVLVPAFSLARSQEVLSVLAERDFPYPVYYDGMSREITEIMLG
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
FREFLNKPDLLKKAYDNFNYVKGWEDRHRAWKERGVIVASAGMLKGGPAVYYFKKLSENS
HHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCEEEEHHHCCCC
KNAIFLVSYQAINTPGRRLLEMGKFDEYSGLLRARLEIFDFSSHAGRRQLLEIVKSIKGL
CCEEEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCC
EKVVLVHGSPDNETSLADLIKQETGVEVIIPENGQEISL
EEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]