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The map label for this gene is ilvC [H]

Identifier: 227827822

GI number: 227827822

Start: 1445813

End: 1446820

Strand: Direct

Name: ilvC [H]

Synonym: M1425_1555

Alternate gene names: 227827822

Gene position: 1445813-1446820 (Clockwise)

Preceding gene: 227827821

Following gene: 227827823

Centisome position: 55.42

GC content: 38.1

Gene sequence:

>1008_bases
GTGAAGTCTACGTCAAAGATCTACACTGATAAAGATAGTAATTTAGATGTAATTAAGGGTAAGAGAATAGCGGTCTTAGG
CTATGGAAGTCAGGGAAGAGCATGGGCTCAGAATTTAAGAGATTCGGGATTAAATGTTGTAGTGGGATTGGAAAGGGAAG
GAAAATCATGGGAATTGGCTAAGAGCGATGGGATAATTCCACTTCATACTAAGGATGCAGTTAAGGATGCTGATATAATA
ATCTTCTTGGTGCCAGATATGGTTCAGAGGACGCTATGGTTAGAGAGCGTACAGCCTTATATGAAAAAAGGTGCAGATTT
AGTATTTGCACATGGGTTTAACATTCACTATAAACTAATCGAACCACCTAAGGATTCAGATGTGTATATGATAGCTCCTA
AAGGTCCAGGTCCTACAGTTAGAGAGTACTATAAGGCTGGAGGTGGTGTTCCAGCTTTAGTTGCAATTCAACAAGATGTA
AGTGGTACAGCTCTTCAAAAGGCTTTAGCAATAGCTAAAGGTATAGGTGCTACTAGGGCCGGCGTAATTCCAACTACCTT
TAAGGAAGAGACTGAGACAGACTTATTTGGAGAGCAAGTAATACTTGTGGGAGGAATAATGGAACTTATGAAAGCTGCAT
TTGAAACCTTAGTAGAGGAAGGATATCAACCAGAAGTAGCCTACTTTGAAACTATAAATGAGCTTAAGATGTTGGTGGAT
TTAGTTTATGAAAAGGGAATTACTGGTATGTTAAAAGCAGTATCTGATACTGCTAAATATGGTGGTATGACAGTAGGAAA
GTTTGTAATAAATGAGGATGTAAGAAAAAGAATGAAAGAGGCTTTACAGAGAATAAAGAGTGGAAAATTTGCTGAAGAAT
GGGTAGAAGAATATGGTAGAGGTATGCCAACTGTAGTTAATGGTCTCTCACAAGTTCAGAATAGTTTAGAAGAGAAGATT
GGCAATCAACTAAAGGATCTGATCCAAAAAGGAAAGCCTAAAAGCTAA

Upstream 100 bases:

>100_bases
AGGGATGGAAAGGTGATAGAGAATCAATCAGAAGGGGTAAAAGAAGGTGACATGATAATTTATGTACCAGTTTTCAATAG
AGTAAAAGGATATAGTTGGG

Downstream 100 bases:

>100_bases
AATATTACAAACTTTTATTTATATAATACCTTATGAACGCTAAAAAGAGGAAAGGTTCTGCAGTAGAAAGAAATATCGTA
GGTAAGTTAAGGGATAAGGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGIIPLHTKDAVKDADII
IFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIEPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDV
SGTALQKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVD
LVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSQVQNSLEEKI
GNQLKDLIQKGKPKS

Sequences:

>Translated_335_residues
MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGIIPLHTKDAVKDADII
IFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIEPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDV
SGTALQKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVD
LVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSQVQNSLEEKI
GNQLKDLIQKGKPKS
>Mature_335_residues
MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGIIPLHTKDAVKDADII
IFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIEPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDV
SGTALQKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVD
LVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSQVQNSLEEKI
GNQLKDLIQKGKPKS

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=35.5400696864112, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=257, Percent_Identity=39.6887159533074, Blast_Score=168, Evalue=1e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36847; Mature: 36847

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELA
CCCCCCEECCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
KSDGIIPLHTKDAVKDADIIIFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLI
CCCCEEEECCHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
EPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDVSGTALQKALAIAKGIGATRA
CCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
GVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVD
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGR
HHHHCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GMPTVVNGLSQVQNSLEEKIGNQLKDLIQKGKPKS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSTSKIYTDKDSNLDVIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELA
CCCCCCEECCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
KSDGIIPLHTKDAVKDADIIIFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLI
CCCCEEEECCHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
EPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAIQQDVSGTALQKALAIAKGIGATRA
CCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
GVIPTTFKEETETDLFGEQVILVGGIMELMKAAFETLVEEGYQPEVAYFETINELKMLVD
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVYEKGITGMLKAVSDTAKYGGMTVGKFVINEDVRKRMKEALQRIKSGKFAEEWVEEYGR
HHHHCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GMPTVVNGLSQVQNSLEEKIGNQLKDLIQKGKPKS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA