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The map label for this gene is pyrD [H]

Identifier: 227827789

GI number: 227827789

Start: 1420484

End: 1421356

Strand: Direct

Name: pyrD [H]

Synonym: M1425_1522

Alternate gene names: 227827789

Gene position: 1420484-1421356 (Clockwise)

Preceding gene: 227827788

Following gene: 227827790

Centisome position: 54.45

GC content: 35.85

Gene sequence:

>873_bases
ATGATTAAGATAAAAGATATTACATTTAACGATCCTTTAACGATAGCTTCAGGAATTATACCAGATGTTCCAAATTATGT
AACGACAGTTTGTGAGAAATATAAGCCATCTGCAATTACCACGAAAACAGTGACACTTAATCCCTTAGGACCTCATAAAC
CTCCTACAGTCATAAAACTTCACGATGGTATCTATATGAACGCCATAGGTTTAGGAAATCCGGGTGCAAAAGCCATAAAT
GAAATGAACGTTTCATGTCCCCTTATAGTAAGCGTTGGTGGTGCTTCCATAAATGAAATAAAAGAAGTGGTAAAAGTTAT
TGAGAGTAAGGCGAAGATAATAGAAATAAACGTGAGTAGTCCTAACAGAAAAGGTTATGGAGAATCATTATCTACGTTAA
TTGGGGATATAGTCGAAAACGTCAAAAGTGTGACCAGATTACCGGTATTTGTTAAATTAGGTCCTTGGGATAACGTTGTT
GAACTTGCGGGAAGGGCTTTAGAAAAAGGTGCGGATGGATTTACTCTTATAAATACTATAAGGGGATTAATTGTTGATAT
AGAGACTTTTAAGCCAATTCTATACTACGGTACGGGTGGAGTTTCTGGTAGGTGCCTTTATCCTGTTGCTCTTAGGATAA
TAAGAGACGTTTATGAAGAGTATGGAGTTGACATTATAGGAGTTGGCGGTGTATACGATTGGACTGACGTTATTGGAATG
TTAGCGGTTGGTGCTAAACTAGTAGGTTTAGGTACTGTATTAATTGAGAAAGGATTTAGCATTATTGAGGAAATTCGGAA
AGGTTTGCAATCCTATTTATTTGAAAAGGGTTTAAAATTTGAAGATATTATAGGTATTTCAGTGAGAAGATAA

Upstream 100 bases:

>100_bases
TAAAGGCTTCAGTTTACATGACTATCGTTCAAGGAAAGGCGAGTAATTTAGAGGGAGAGGTATTTCCAGTGAAGGGAATA
AATCCATTTGGTGAAGATAA

Downstream 100 bases:

>100_bases
AATGGTTAGGCCGGTAATGAAAGGACGAGATTTAGAAACGTTAGTATTCCTAGGGAGATTAAAAGAGGTAAAAGTAGAGT
ATTGTGATGAAGAAAAGAAG

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MIKIKDITFNDPLTIASGIIPDVPNYVTTVCEKYKPSAITTKTVTLNPLGPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EMNVSCPLIVSVGGASINEIKEVVKVIESKAKIIEINVSSPNRKGYGESLSTLIGDIVENVKSVTRLPVFVKLGPWDNVV
ELAGRALEKGADGFTLINTIRGLIVDIETFKPILYYGTGGVSGRCLYPVALRIIRDVYEEYGVDIIGVGGVYDWTDVIGM
LAVGAKLVGLGTVLIEKGFSIIEEIRKGLQSYLFEKGLKFEDIIGISVRR

Sequences:

>Translated_290_residues
MIKIKDITFNDPLTIASGIIPDVPNYVTTVCEKYKPSAITTKTVTLNPLGPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EMNVSCPLIVSVGGASINEIKEVVKVIESKAKIIEINVSSPNRKGYGESLSTLIGDIVENVKSVTRLPVFVKLGPWDNVV
ELAGRALEKGADGFTLINTIRGLIVDIETFKPILYYGTGGVSGRCLYPVALRIIRDVYEEYGVDIIGVGGVYDWTDVIGM
LAVGAKLVGLGTVLIEKGFSIIEEIRKGLQSYLFEKGLKFEDIIGISVRR
>Mature_290_residues
MIKIKDITFNDPLTIASGIIPDVPNYVTTVCEKYKPSAITTKTVTLNPLGPHKPPTVIKLHDGIYMNAIGLGNPGAKAIN
EMNVSCPLIVSVGGASINEIKEVVKVIESKAKIIEINVSSPNRKGYGESLSTLIGDIVENVKSVTRLPVFVKLGPWDNVV
ELAGRALEKGADGFTLINTIRGLIVDIETFKPILYYGTGGVSGRCLYPVALRIIRDVYEEYGVDIIGVGGVYDWTDVIGM
LAVGAKLVGLGTVLIEKGFSIIEEIRKGLQSYLFEKGLKFEDIIGISVRR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=26.1682242990654, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082059, Length=218, Percent_Identity=28.8990825688073, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71984108, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=297, Percent_Identity=27.6094276094276, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640763, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18858217, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31345; Mature: 31345

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIKDITFNDPLTIASGIIPDVPNYVTTVCEKYKPSAITTKTVTLNPLGPHKPPTVIKL
CEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEE
HDGIYMNAIGLGNPGAKAINEMNVSCPLIVSVGGASINEIKEVVKVIESKAKIIEINVSS
ECCEEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCC
PNRKGYGESLSTLIGDIVENVKSVTRLPVFVKLGPWDNVVELAGRALEKGADGFTLINTI
CCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
RGLIVDIETFKPILYYGTGGVSGRCLYPVALRIIRDVYEEYGVDIIGVGGVYDWTDVIGM
HHHEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
LAVGAKLVGLGTVLIEKGFSIIEEIRKGLQSYLFEKGLKFEDIIGISVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECEEECC
>Mature Secondary Structure
MIKIKDITFNDPLTIASGIIPDVPNYVTTVCEKYKPSAITTKTVTLNPLGPHKPPTVIKL
CEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEE
HDGIYMNAIGLGNPGAKAINEMNVSCPLIVSVGGASINEIKEVVKVIESKAKIIEINVSS
ECCEEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCC
PNRKGYGESLSTLIGDIVENVKSVTRLPVFVKLGPWDNVVELAGRALEKGADGFTLINTI
CCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHH
RGLIVDIETFKPILYYGTGGVSGRCLYPVALRIIRDVYEEYGVDIIGVGGVYDWTDVIGM
HHHEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHH
LAVGAKLVGLGTVLIEKGFSIIEEIRKGLQSYLFEKGLKFEDIIGISVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]