Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 227827788

GI number: 227827788

Start: 1419318

End: 1420487

Strand: Direct

Name: pyrC [H]

Synonym: M1425_1521

Alternate gene names: 227827788

Gene position: 1419318-1420487 (Clockwise)

Preceding gene: 227827787

Following gene: 227827789

Centisome position: 54.4

GC content: 34.36

Gene sequence:

>1170_bases
ATGATCTTGTGGATTAAGGGAAAAGCGTACTTGAATAAGGAGATTAAGGAAGTTTGTATAAATTTTGATAGACGAATAAA
GGAAATCAAATCGATTTGTAAACCAGATATTGATTTACCACAAGGTACATTAATACTACCTGGGGCAATAGATCTTCATA
CTCACATAAGAGGATTAAAATTGTCATATAAAGAAGATGTAGTATCAGGGACTAGCGAAGCTTCTTACGGTGGGGTTACA
TTAATAGGAGATATGCCAAATACTATACCATTTGTAAACACGGTAGAGACGATAACTACTAAGTTAAAAGAGTTTGAATA
TTACTCTAGAGTTGATTACTTCGTTTATTCTGGCGTTACTAAGGATTTTGAGAAAGTTGATAAATTGCCTATAGCTGGTT
ACAAGATATTTCCCGAAGATCTAGAGAAGGAAGAGACATTTGAGGTTTTAAAGTCTAGAAAACTGAAAATTCTTCACCCA
GAAGTTCCGTTAGCATTAAAAAGTACTAGAAAACTAAGGTTGAACATATGGTACGAGATAGGAGCATTATATTATGTAAA
GGCCTATCAAAATGTTCATATAACTCATGCGACTAATATACGTACTGTAAGATTGGCTAAAGAGTTAGGTTTTACTGTAG
ATATAACACCTCATCATCTATTAGTTAATGGTGAGAAGGATTGCTTAACCAAGGTTAATCCACCAATAAGAGATATAAAT
GAAAGGCTTTGGTTATTACAAGCTATAAGTGAAGTAGATACAATTGTAAGTGATCACGCTCCTCATGCAAGTTTCGAAAA
ACTGCAACCTTACGAGGTATGTCCACCCGGTATAGCTGCTGTCTCGTTTACAGTTCCTTTTATCTTAACGTTAGTCAGTA
AAGGTATAATTAGCATTGACAGAGCGGTAGAACTCATTTCTACAAATCCAGCTAGAATATTGAATATTCCTTATGGTGAG
ATTAAAGAAAACAATTATGCAAATTTTACCATAATACAATTTAACGATTGGAGATATTCGACTAAATACTCTAAGGTTAT
TGAAACTCCTCTAGACGGATTTCCGCTAAAGGCTTCAGTTTACATGACTATCGTTCAAGGAAAGGCGAGTAATTTAGAGG
GAGAGGTATTTCCAGTGAAGGGAATAAATCCATTTGGTGAAGATAAATGA

Upstream 100 bases:

>100_bases
TTCAATAGATGGGTTAAGATGAATTGTAATCTAGGAGTTTGCGGAGTATGTGAAGTAAAAGGTAAATTAACTTGTATAGA
TGGTCCTTTCATGAGGCTTG

Downstream 100 bases:

>100_bases
TTAAGATAAAAGATATTACATTTAACGATCCTTTAACGATAGCTTCAGGAATTATACCAGATGTTCCAAATTATGTAACG
ACAGTTTGTGAGAAATATAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MILWIKGKAYLNKEIKEVCINFDRRIKEIKSICKPDIDLPQGTLILPGAIDLHTHIRGLKLSYKEDVVSGTSEASYGGVT
LIGDMPNTIPFVNTVETITTKLKEFEYYSRVDYFVYSGVTKDFEKVDKLPIAGYKIFPEDLEKEETFEVLKSRKLKILHP
EVPLALKSTRKLRLNIWYEIGALYYVKAYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVNGEKDCLTKVNPPIRDIN
ERLWLLQAISEVDTIVSDHAPHASFEKLQPYEVCPPGIAAVSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYGE
IKENNYANFTIIQFNDWRYSTKYSKVIETPLDGFPLKASVYMTIVQGKASNLEGEVFPVKGINPFGEDK

Sequences:

>Translated_389_residues
MILWIKGKAYLNKEIKEVCINFDRRIKEIKSICKPDIDLPQGTLILPGAIDLHTHIRGLKLSYKEDVVSGTSEASYGGVT
LIGDMPNTIPFVNTVETITTKLKEFEYYSRVDYFVYSGVTKDFEKVDKLPIAGYKIFPEDLEKEETFEVLKSRKLKILHP
EVPLALKSTRKLRLNIWYEIGALYYVKAYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVNGEKDCLTKVNPPIRDIN
ERLWLLQAISEVDTIVSDHAPHASFEKLQPYEVCPPGIAAVSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYGE
IKENNYANFTIIQFNDWRYSTKYSKVIETPLDGFPLKASVYMTIVQGKASNLEGEVFPVKGINPFGEDK
>Mature_389_residues
MILWIKGKAYLNKEIKEVCINFDRRIKEIKSICKPDIDLPQGTLILPGAIDLHTHIRGLKLSYKEDVVSGTSEASYGGVT
LIGDMPNTIPFVNTVETITTKLKEFEYYSRVDYFVYSGVTKDFEKVDKLPIAGYKIFPEDLEKEETFEVLKSRKLKILHP
EVPLALKSTRKLRLNIWYEIGALYYVKAYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVNGEKDCLTKVNPPIRDIN
ERLWLLQAISEVDTIVSDHAPHASFEKLQPYEVCPPGIAAVSFTVPFILTLVSKGIISIDRAVELISTNPARILNIPYGE
IKENNYANFTIIQFNDWRYSTKYSKVIETPLDGFPLKASVYMTIVQGKASNLEGEVFPVKGINPFGEDK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=373, Percent_Identity=26.2734584450402, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=361, Percent_Identity=27.9778393351801, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24642586, Length=363, Percent_Identity=28.3746556473829, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44121; Mature: 44121

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILWIKGKAYLNKEIKEVCINFDRRIKEIKSICKPDIDLPQGTLILPGAIDLHTHIRGLK
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEHHHHHCCEE
LSYKEDVVSGTSEASYGGVTLIGDMPNTIPFVNTVETITTKLKEFEYYSRVDYFVYSGVT
EEHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCC
KDFEKVDKLPIAGYKIFPEDLEKEETFEVLKSRKLKILHPEVPLALKSTRKLRLNIWYEI
HHHHHHHCCCCCCEEECHHHCCHHHHHHHHHHCCEEEECCCCCEEECCCCEEEEEEEEEE
GALYYVKAYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVNGEKDCLTKVNPPIRDIN
CEEEEEEEECEEEEEECCCEEEEEEHHHCCCEEEECCCEEEEECCHHHHHCCCCCHHHHH
ERLWLLQAISEVDTIVSDHAPHASFEKLQPYEVCPPGIAAVSFTVPFILTLVSKGIISID
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
RAVELISTNPARILNIPYGEIKENNYANFTIIQFNDWRYSTKYSKVIETPLDGFPLKASV
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEECCEECCHHHHHHHCCCCCCCCEEEE
YMTIVQGKASNLEGEVFPVKGINPFGEDK
EEEEEECCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MILWIKGKAYLNKEIKEVCINFDRRIKEIKSICKPDIDLPQGTLILPGAIDLHTHIRGLK
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEHHHHHCCEE
LSYKEDVVSGTSEASYGGVTLIGDMPNTIPFVNTVETITTKLKEFEYYSRVDYFVYSGVT
EEHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCC
KDFEKVDKLPIAGYKIFPEDLEKEETFEVLKSRKLKILHPEVPLALKSTRKLRLNIWYEI
HHHHHHHCCCCCCEEECHHHCCHHHHHHHHHHCCEEEECCCCCEEECCCCEEEEEEEEEE
GALYYVKAYQNVHITHATNIRTVRLAKELGFTVDITPHHLLVNGEKDCLTKVNPPIRDIN
CEEEEEEEECEEEEEECCCEEEEEEHHHCCCEEEECCCEEEEECCHHHHHCCCCCHHHHH
ERLWLLQAISEVDTIVSDHAPHASFEKLQPYEVCPPGIAAVSFTVPFILTLVSKGIISID
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
RAVELISTNPARILNIPYGEIKENNYANFTIIQFNDWRYSTKYSKVIETPLDGFPLKASV
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEECCEECCHHHHHHHCCCCCCCCEEEE
YMTIVQGKASNLEGEVFPVKGINPFGEDK
EEEEEECCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]