Click here to switch to the map view.

The map label for this gene is cdc6 [H]

Identifier: 227827642

GI number: 227827642

Start: 1296564

End: 1297805

Strand: Direct

Name: cdc6 [H]

Synonym: M1425_1370

Alternate gene names: 227827642

Gene position: 1296564-1297805 (Clockwise)

Preceding gene: 227827641

Following gene: 227827643

Centisome position: 49.7

GC content: 33.41

Gene sequence:

>1242_bases
TTGGTTTCAGCTAAGGATATACTTTCAGATAGTTTGAGATCATCAGTGTTAATAATCAAGCATAAGGATAAGCTTTCGCC
AGATTACGTGCCGGAAAATTTACCACATAGAGAAGAAAAGATTAAGGAATTAGGTTTCGTATTTAGAGATTTACTAGCTG
GAGATGCTAAAGATTCAGAAAGAGTTGTAATAGTAGGTAGGACAGGTACTGGGAAAACAGCAACTGTTAGATTGTTTGGT
AAAAATTTTGAAGATATTGCGGAGAGGGAGTACGGAGTTAAAGTAAAGTATGTTCATGTAAATTGTTATAGGCATAGAAC
ATTGTACTTGATAAGTCAAGAAATAGCTAACGCGTTAAAACTACCAATACCCTCGAGGGGATTATCAGCACAAGAAGTAT
TTAAGATTATCCATGAATATTTAGATAGGAGAAATATACATCTAATAGTTGCATTAGATGAGTTTGGACATTTCTTGAAT
ACTGCAAATACTGAGGAAATATACTTCTTAGTAAGATTGTATGATGAAATATCAGCAATAATAAAGAGAATTAGTTATAT
ATTTATAGTTAATGAAAGCCATTCTATTTATAAATTAGATAGAAGTATAAGGGATCATATAGCAAGAAGATTAATTGAAT
TTCCCCCTTACAGGTCTATGGAACTTTACGATATTTTGAAGTATAGGGTAGATGAAGCTTTTAATGATAATGCTGTAGAT
GATGAGGTATTACAATTCATATCCAATACTTATGGCTATGATAAAGGGGGTAATGGTAATGCCAGAATTGCAATAGAGAC
TCTAAGTTTAGCTGGAGAAATAGCAGAGAAGGAGGGATCACCAGTGGTATTGTTAGATCATGCTAAGAAGGCTAATTCTA
CAATAAATCCAGAGATTCAAGAGATTGTGGATAGTTTATCGTATCTTGATTTGCATCAACTTATACTCTTGAAAGCGCTG
ATACGGGTTTTAAATAAGAGTAAAGCTGATGAGGTTACAATGGGAACTTTAGAAGAGGAATATATATCATTAGCCAGAGA
GTTTAATGAGGAACCTAGAAGACATACACAAGTTTATGAGTATCTGAGGAAACTTAAGGTAATAGGGATAATTAATACTA
GGCAGAGTGGGAAGGGAATGAGAGGAAGAACGACTCTAGTTTCTCTTTCTCTACCATTAGATAAAAGATTAGATGATTAT
ATTATGCAACAAATAGTGGTGAGGTTAAAATCGAAGGCTTAA

Upstream 100 bases:

>100_bases
CTGGGATATCGCTTTTGAGAAAGAATCAAGAAAAGTTTCGGACTACTCTCTTAGATAAAATATAAGGTAATACCGCTTAA
TTTAGATTGGGGTAAAAGTT

Downstream 100 bases:

>100_bases
TCTATAATTCATCTAAAATGAAGATATTATCTATATTGATAAAGCATGGTGATATGAATATCACTAAATTATATAGATTG
TCTAAGATCCATTACGATAA

Product: cell division control protein 6

Products: NA

Alternate protein names: CDC6 homolog 2 [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFVFRDLLAGDAKDSERVVIVGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHVNCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKIIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYRSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIVDSLSYLDLHQLILLKAL
IRVLNKSKADEVTMGTLEEEYISLAREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIVVRLKSKA

Sequences:

>Translated_413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFVFRDLLAGDAKDSERVVIVGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHVNCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKIIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYRSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIVDSLSYLDLHQLILLKAL
IRVLNKSKADEVTMGTLEEEYISLAREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIVVRLKSKA
>Mature_413_residues
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFVFRDLLAGDAKDSERVVIVGRTGTGKTATVRLFG
KNFEDIAEREYGVKVKYVHVNCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKIIHEYLDRRNIHLIVALDEFGHFLN
TANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYRSMELYDILKYRVDEAFNDNAVD
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIVDSLSYLDLHQLILLKAL
IRVLNKSKADEVTMGTLEEEYISLAREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDY
IMQQIVVRLKSKA

Specific function: Might be involved in the initiation of DNA replication. Binds both single-strand and double-strand DNA. Has a weak ATPase activity. Strongly inhibits the ATPase and DNA helicase activity of the MCM protein [H]

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family [H]

Homologues:

Organism=Homo sapiens, GI4502703, Length=345, Percent_Identity=22.8985507246377, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355681, Length=347, Percent_Identity=21.9020172910663, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C [H]

EC number: NA

Molecular weight: Translated: 47439; Mature: 47439

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFVFRDLLAGDAKDSE
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
RVVIVGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHVNCYRHRTLYLISQEIANALK
EEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEEEECHHHEEHHHHHHHHHC
LPIPSRGLSAQEVFKIIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAI
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYRSMELYDILKYRVDEAFNDNAVD
HHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQ
HHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EIVDSLSYLDLHQLILLKALIRVLNKSKADEVTMGTLEEEYISLAREFNEEPRRHTQVYE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIVVRLKSKA
HHHHHHHEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFVFRDLLAGDAKDSE
CCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
RVVIVGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHVNCYRHRTLYLISQEIANALK
EEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEEEEECHHHEEHHHHHHHHHC
LPIPSRGLSAQEVFKIIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAI
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYRSMELYDILKYRVDEAFNDNAVD
HHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
DEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQ
HHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EIVDSLSYLDLHQLILLKALIRVLNKSKADEVTMGTLEEEYISLAREFNEEPRRHTQVYE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIVVRLKSKA
HHHHHHHEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]