Click here to switch to the map view.

The map label for this gene is lpd [H]

Identifier: 227827386

GI number: 227827386

Start: 1052350

End: 1053687

Strand: Direct

Name: lpd [H]

Synonym: M1425_1105

Alternate gene names: 227827386

Gene position: 1052350-1053687 (Clockwise)

Preceding gene: 227827385

Following gene: 227827387

Centisome position: 40.34

GC content: 36.47

Gene sequence:

>1338_bases
ATGAAATATGATATAGTAGTGATTGGCGGCGGTACTGCTGGTTATGTTGCTGGAAGCATATTGGCGCGAAAAGGCAAGAA
GGTAATAGTAATCGAAAAGGAGAAATTTGGCGGAGTTTGTGTAAACTTCGGTTGTGTGCCAAGTATTTTTCTTTTTGACG
TAACTTTCTTATTAAACAGATTTAAAGAAATTGTGTACTATCTAGGTTTAGATGGTGAAATTGAATACAAGGATCTTCTT
TTTAGTAAGAGAAATGAAATTGTAAATTATTTATCAAATGCAGGTAGGAGGTTAATTGAGGATTCAGGTGGTGAGACCGA
GTTAGGCGAGGCTGAAATAATTTCTCCTAGTGAAGTAAAGGTAAATGGGAGAATTGTTGAATTCGATAAGTTAATTATAG
CTACCGGTTCAAAACCGATGATACCGAATATTGATGGTATTGAAGATGCAATAAGTGAGGATGATGCGGTCAATTTGAAT
TTCATACCTTCTTCCATGGTAGTAATTGGTGGAGGTTACGCAGGAGTTGAGATAGCTCAAATATATTCCAGATTAGGATC
ACAAGTTACCTTATTATCTAGAAGTGAAATTTTACCAACTTTTCCAGAGGATGTTAGGAGTGTTGTGAAAGATTCCTTAG
AGTTCGATGGAGTAAATGTAGTGGAAAACACTAGAATAGTGAAGCTTCGTGATGGTAAAGTGATCACGGAGAAGGGTGAG
ATAGAGGGAAATGTGATAGTTTACGCCACTGGAAGAAGACCACAGCTCCCCAAAGGTATAGAGAAACTCGGGCTAGAAAT
TGATGAATGTGGAATAAATGTTGACAAATATAAACAAATAAAGAATAATGCATATGCAATAGGTGATGTGATAAATAAGG
AAAGGAAAACGGCACATTCGGCAATGTTCGATGCCTTAGTTGCGTCACTACATATCCTTAAGGAGACTACGTTTATTCCA
CCAGACAATTTTAAAATACCTGTAGTATTATACACCGATCCGCAAGTAGGTGTTATAGGTGATCACAAGGAAGCTAAGAA
GTTTTCAGTTTTCCCATTCGCTGCTATCACAAGGGCGATTATTAACGGAATAAAGGATGGCTACGTTAAAATAGGAATAA
ATGAGAGGAATGAGATAGTTTTTGGAGAAGTAATTGGTGACAAAGCTGAAGAATTAATCAATATTTTAACATTAGTAGTA
AATAATAGAATGAGAATAGAGAGTTTAGCGCTAATGCCTTTTGTTCATCCTTCATTATCTGAGGCCATAGTTAACGCAGC
GAAGGGCTTTTTTGATTTAGATGTGGATAGATATAAGAGTAAGGATGGGAAAACTTGA

Upstream 100 bases:

>100_bases
GAAGATGATGTGGTAGAAGGTATAGAACTAGTTGGAGGATCTACGTTAATAGATCTAACAATGGATGCTGATAGGACATT
ATTCTTCTAAATGATCTAGC

Downstream 100 bases:

>100_bases
GGAGTACTTAAGGAAGAAGGGATTTTCCCTATTTAATGAGGGAAAAAGGGAAAGGGTGATAATGGATGACTATGAGTTCT
TTATTGAAAACTCAGCCATA

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKYDIVVIGGGTAGYVAGSILARKGKKVIVIEKEKFGGVCVNFGCVPSIFLFDVTFLLNRFKEIVYYLGLDGEIEYKDLL
FSKRNEIVNYLSNAGRRLIEDSGGETELGEAEIISPSEVKVNGRIVEFDKLIIATGSKPMIPNIDGIEDAISEDDAVNLN
FIPSSMVVIGGGYAGVEIAQIYSRLGSQVTLLSRSEILPTFPEDVRSVVKDSLEFDGVNVVENTRIVKLRDGKVITEKGE
IEGNVIVYATGRRPQLPKGIEKLGLEIDECGINVDKYKQIKNNAYAIGDVINKERKTAHSAMFDALVASLHILKETTFIP
PDNFKIPVVLYTDPQVGVIGDHKEAKKFSVFPFAAITRAIINGIKDGYVKIGINERNEIVFGEVIGDKAEELINILTLVV
NNRMRIESLALMPFVHPSLSEAIVNAAKGFFDLDVDRYKSKDGKT

Sequences:

>Translated_445_residues
MKYDIVVIGGGTAGYVAGSILARKGKKVIVIEKEKFGGVCVNFGCVPSIFLFDVTFLLNRFKEIVYYLGLDGEIEYKDLL
FSKRNEIVNYLSNAGRRLIEDSGGETELGEAEIISPSEVKVNGRIVEFDKLIIATGSKPMIPNIDGIEDAISEDDAVNLN
FIPSSMVVIGGGYAGVEIAQIYSRLGSQVTLLSRSEILPTFPEDVRSVVKDSLEFDGVNVVENTRIVKLRDGKVITEKGE
IEGNVIVYATGRRPQLPKGIEKLGLEIDECGINVDKYKQIKNNAYAIGDVINKERKTAHSAMFDALVASLHILKETTFIP
PDNFKIPVVLYTDPQVGVIGDHKEAKKFSVFPFAAITRAIINGIKDGYVKIGINERNEIVFGEVIGDKAEELINILTLVV
NNRMRIESLALMPFVHPSLSEAIVNAAKGFFDLDVDRYKSKDGKT
>Mature_445_residues
MKYDIVVIGGGTAGYVAGSILARKGKKVIVIEKEKFGGVCVNFGCVPSIFLFDVTFLLNRFKEIVYYLGLDGEIEYKDLL
FSKRNEIVNYLSNAGRRLIEDSGGETELGEAEIISPSEVKVNGRIVEFDKLIIATGSKPMIPNIDGIEDAISEDDAVNLN
FIPSSMVVIGGGYAGVEIAQIYSRLGSQVTLLSRSEILPTFPEDVRSVVKDSLEFDGVNVVENTRIVKLRDGKVITEKGE
IEGNVIVYATGRRPQLPKGIEKLGLEIDECGINVDKYKQIKNNAYAIGDVINKERKTAHSAMFDALVASLHILKETTFIP
PDNFKIPVVLYTDPQVGVIGDHKEAKKFSVFPFAAITRAIINGIKDGYVKIGINERNEIVFGEVIGDKAEELINILTLVV
NNRMRIESLALMPFVHPSLSEAIVNAAKGFFDLDVDRYKSKDGKT

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=30.8026030368764, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI50301238, Length=364, Percent_Identity=27.7472527472527, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=23.7777777777778, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=23.7777777777778, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=23.7777777777778, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=23.7777777777778, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=23.7777777777778, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI291045266, Length=356, Percent_Identity=24.7191011235955, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI22035672, Length=454, Percent_Identity=22.6872246696035, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=465, Percent_Identity=28.8172043010753, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=26.6666666666667, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87082354, Length=476, Percent_Identity=24.5798319327731, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789915, Length=340, Percent_Identity=26.7647058823529, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789065, Length=186, Percent_Identity=27.4193548387097, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=29.0948275862069, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=335, Percent_Identity=28.3582089552239, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=335, Percent_Identity=28.3582089552239, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17557007, Length=331, Percent_Identity=26.2839879154079, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=232, Percent_Identity=26.7241379310345, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=30.1486199575372, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=27.3504273504274, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=482, Percent_Identity=26.9709543568465, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=30.7368421052632, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=24.8936170212766, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=24.8936170212766, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=24.8936170212766, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737741, Length=470, Percent_Identity=22.7659574468085, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48929; Mature: 48929

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDIVVIGGGTAGYVAGSILARKGKKVIVIEKEKFGGVCVNFGCVPSIFLFDVTFLLNR
CEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
FKEIVYYLGLDGEIEYKDLLFSKRNEIVNYLSNAGRRLIEDSGGETELGEAEIISPSEVK
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCEE
VNGRIVEFDKLIIATGSKPMIPNIDGIEDAISEDDAVNLNFIPSSMVVIGGGYAGVEIAQ
ECCEEEEEEEEEEEECCCCCCCCCCCHHHHCCCCCCEEEEEECCCEEEEECCCCHHHHHH
IYSRLGSQVTLLSRSEILPTFPEDVRSVVKDSLEFDGVNVVENTRIVKLRDGKVITEKGE
HHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEECCCEEEEEECCEEEEECCC
IEGNVIVYATGRRPQLPKGIEKLGLEIDECGINVDKYKQIKNNAYAIGDVINKERKTAHS
CCCCEEEEECCCCCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHH
AMFDALVASLHILKETTFIPPDNFKIPVVLYTDPQVGVIGDHKEAKKFSVFPFAAITRAI
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEECCCCCCCEEECCHHHHHHHHH
INGIKDGYVKIGINERNEIVFGEVIGDKAEELINILTLVVNNRMRIESLALMPFVHPSLS
HHCCCCCEEEEEECCCCCEEEEHHHCHHHHHHHHHHHHHHCCCEEEEHEEECCCCCCCHH
EAIVNAAKGFFDLDVDRYKSKDGKT
HHHHHHHCCCEECCHHHHCCCCCCC
>Mature Secondary Structure
MKYDIVVIGGGTAGYVAGSILARKGKKVIVIEKEKFGGVCVNFGCVPSIFLFDVTFLLNR
CEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
FKEIVYYLGLDGEIEYKDLLFSKRNEIVNYLSNAGRRLIEDSGGETELGEAEIISPSEVK
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCEE
VNGRIVEFDKLIIATGSKPMIPNIDGIEDAISEDDAVNLNFIPSSMVVIGGGYAGVEIAQ
ECCEEEEEEEEEEEECCCCCCCCCCCHHHHCCCCCCEEEEEECCCEEEEECCCCHHHHHH
IYSRLGSQVTLLSRSEILPTFPEDVRSVVKDSLEFDGVNVVENTRIVKLRDGKVITEKGE
HHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEECCCEEEEEECCEEEEECCC
IEGNVIVYATGRRPQLPKGIEKLGLEIDECGINVDKYKQIKNNAYAIGDVINKERKTAHS
CCCCEEEEECCCCCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHH
AMFDALVASLHILKETTFIPPDNFKIPVVLYTDPQVGVIGDHKEAKKFSVFPFAAITRAI
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEECCCCCCCEEECCHHHHHHHHH
INGIKDGYVKIGINERNEIVFGEVIGDKAEELINILTLVVNNRMRIESLALMPFVHPSLS
HHCCCCCEEEEEECCCCCEEEEHHHCHHHHHHHHHHHHHHCCCEEEEHEEECCCCCCCHH
EAIVNAAKGFFDLDVDRYKSKDGKT
HHHHHHHCCCEECCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA