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The map label for this gene is coxL [H]

Identifier: 227827172

GI number: 227827172

Start: 806845

End: 809112

Strand: Direct

Name: coxL [H]

Synonym: M1425_0853

Alternate gene names: 227827172

Gene position: 806845-809112 (Clockwise)

Preceding gene: 227827171

Following gene: 227827173

Centisome position: 30.93

GC content: 37.65

Gene sequence:

>2268_bases
ATGTTTAAGGAAGGGTTGCGGTTTGTAAAGGGAGAAGGTAATTACATAGACGATTTTGTATTAAAAGAAGTAAAGAATTA
TTTTTCAGCCTCGATAGTTAGATCTCCTTATGCTCACGCTATGATTAGGTCTATAGATAAAAGCGATGCGGAGAAATTGA
ACGGAGTTATAAAGGTAATTACGTTTAATGACATAAGGAATCTCTTAGACCCCTTTCCCCTTTCTTTGGACGTAAATTTA
GATTTCTATCCAATGGCTAGAGAAAAGACTTTATATTACGGTGAACCGGTAGCAGTGATTATAGCAAAGGATGATTACGT
GGCTGAAGACGCTAAGGAATTACTTCAAATAGATTATGAACCACTAGAATCAATAGTCAGTATAGAAAATGCTATAAATA
GTGGACCTATTCATCCTACTCTGAAATCTAATGTTATATTAGATAAAACTCTTGTTTACGGAAGATTCGAATATGAGATT
AAGAAATCGCCAATTCTAATTGAGGAAAGAATTAGATTCCCAAGATATTCTTCTTCTCCCCTAGAAACCTACGAAATTTT
AGCTAGATACAACGGAGAAGAGTATGAAATTTTTTCCAATTTTCAAGGTCCATTTACTATTCACTACCTACTAACAAAGG
CGTTGAAATCTAAAGTAGTATTGAAAGGACCGCGTGATATAGGAGGATCTTTCGGTATAAAGAGCGCAATTTACCCATAC
ATGGCATTGATAGCTGTAGCGAGTAGAGTGGTAAAAAGACCAGTGAAGTGGGTTGAAACTAGGAGTGAACATATAACCTC
AAGTTCTGTCGGAGCTGAAAGGGAATCTTTAATCAGAATATATGGTGATAAAGATGGCATAATTAACGCAATTGAAATGG
ATCTTGTAGATAACCTAGGAGCATATCCAAGACCTCCAGAACCAGGTAATTTGCTTAGGAATCACGGTAATTTGACTGGA
GCTTATGATATTAAGGGATTAAAGGTTAGGTATAGGGCAGTCTTAACTAATACCGTACCTACTGGGTTAAACAGGGGTTA
TGGAGGACCTCATTTATATTTTGCCTTAGAGACTGTCATAGATAGCTTTGCAAGGGAAATAGGTATGGATCCTATTGATG
TAAGATTAAAGAACGTATTTAAGAAAACTCCATATGAGACTTTAACTGGAGGTAAGTATAACGGTTTCAGTTGTTATAGT
GTATTGAAGAGAATGAAGGAAATATATGAAAAGATAGAGGGAGAAAAAAGAGGAAAGGTAGGGATAGGCGTATCACTTGT
CGTTGAACCCTCTGGGACTAATATAGGTTATTTAGATTTAGCTAGAGAGAGCAAAGACTATTTGCCTAAATCTGCTGCTC
AAGATATCGTTATAGTACAGATAGATCCCTATGGAAAAGTTAAGGTCATGGTAAATGGGACAAATGAAGGGCAGGGGCAT
GAAACGATAATTTCCGAAATCGTATCTAAAAGACTGGGTGTGAATCCCGATGATGTAGAAGTATTATATAGTGTTGATAC
CAATAGACCGTGGGTAGTCTCCTCTGGTAGTTACTCCAGTAGATTCACTCCAATTGTAGTCCAGGCGTTAAATAACGCAT
TGGACCAGTTGGAAAATAGATTACTCTTAGCTGCGTCTGAAATTTTAGGCGTACAGAAGTCCGAGCTAAAAATAGAGAAT
GGCAGAGTGAGAACAATCTCTGGAAATAAGTCAATTTCTGTAAGGCACTTAATTGGAACGTTTTACTGGGATCCTGCGAA
ATTGAAGGGAATAGAGGGGGGTTTAGTTGCAGTGGGTTATTATCAGTCTCCTTACGCTGATGATATCAAAGAGGGTAAAA
TAAATTCCTCAATTTCTTACGGTTGTATGGGTCATGTAGTTGAGGTTTTGATGGACGAAACTGAGATACCGAGAATATCA
AGATATGTAGTAGTACACGATGCCGGTAGGATACTGAATGAAAACTTCGCAAGAGGACAAATTATAGGCTCTACTTTTCA
CGGAATTGAGGTGTCATTATACGCATCGTTAGAGTATAATGAGGAGGGTATTCCTATAACTCAGACGTTTGCGGAATATG
GTGCAATGACAGCCATGGAATCGCCTAAAGTGGAAATAGAGCATTTGGAGAGTGATAGTAACCACTTAGCTGGATTAGGA
GAAGGAGGTACTATGGCTGCACCACCAGCAGTATTTAACGCAATTAGATCACTTGTTGAAGTTAAGAATATACCATTATT
TCTTGAACTAACTAGCAAGAGGAAATAG

Upstream 100 bases:

>100_bases
AGAGAAAAACCTTTGGTTTACTCAGATACAGTGAGGACTTCAAAGAGGGTGTAGAGTCGTTCTTGAACAAGAAAAAGCCT
AAATTTAATGGTAGATAATC

Downstream 100 bases:

>100_bases
TTAGCTGGGGTGATTCAAGTTTCCATTGATAATTGTAATATTCTCTATAAATTAGAATAATTCAATGAAGAAATTATTGT
GTATATTTCTAATAAAGTGG

Product: aldehyde oxidase and xanthine dehydrogenasemolybdopterin binding

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MFKEGLRFVKGEGNYIDDFVLKEVKNYFSASIVRSPYAHAMIRSIDKSDAEKLNGVIKVITFNDIRNLLDPFPLSLDVNL
DFYPMAREKTLYYGEPVAVIIAKDDYVAEDAKELLQIDYEPLESIVSIENAINSGPIHPTLKSNVILDKTLVYGRFEYEI
KKSPILIEERIRFPRYSSSPLETYEILARYNGEEYEIFSNFQGPFTIHYLLTKALKSKVVLKGPRDIGGSFGIKSAIYPY
MALIAVASRVVKRPVKWVETRSEHITSSSVGAERESLIRIYGDKDGIINAIEMDLVDNLGAYPRPPEPGNLLRNHGNLTG
AYDIKGLKVRYRAVLTNTVPTGLNRGYGGPHLYFALETVIDSFAREIGMDPIDVRLKNVFKKTPYETLTGGKYNGFSCYS
VLKRMKEIYEKIEGEKRGKVGIGVSLVVEPSGTNIGYLDLARESKDYLPKSAAQDIVIVQIDPYGKVKVMVNGTNEGQGH
ETIISEIVSKRLGVNPDDVEVLYSVDTNRPWVVSSGSYSSRFTPIVVQALNNALDQLENRLLLAASEILGVQKSELKIEN
GRVRTISGNKSISVRHLIGTFYWDPAKLKGIEGGLVAVGYYQSPYADDIKEGKINSSISYGCMGHVVEVLMDETEIPRIS
RYVVVHDAGRILNENFARGQIIGSTFHGIEVSLYASLEYNEEGIPITQTFAEYGAMTAMESPKVEIEHLESDSNHLAGLG
EGGTMAAPPAVFNAIRSLVEVKNIPLFLELTSKRK

Sequences:

>Translated_755_residues
MFKEGLRFVKGEGNYIDDFVLKEVKNYFSASIVRSPYAHAMIRSIDKSDAEKLNGVIKVITFNDIRNLLDPFPLSLDVNL
DFYPMAREKTLYYGEPVAVIIAKDDYVAEDAKELLQIDYEPLESIVSIENAINSGPIHPTLKSNVILDKTLVYGRFEYEI
KKSPILIEERIRFPRYSSSPLETYEILARYNGEEYEIFSNFQGPFTIHYLLTKALKSKVVLKGPRDIGGSFGIKSAIYPY
MALIAVASRVVKRPVKWVETRSEHITSSSVGAERESLIRIYGDKDGIINAIEMDLVDNLGAYPRPPEPGNLLRNHGNLTG
AYDIKGLKVRYRAVLTNTVPTGLNRGYGGPHLYFALETVIDSFAREIGMDPIDVRLKNVFKKTPYETLTGGKYNGFSCYS
VLKRMKEIYEKIEGEKRGKVGIGVSLVVEPSGTNIGYLDLARESKDYLPKSAAQDIVIVQIDPYGKVKVMVNGTNEGQGH
ETIISEIVSKRLGVNPDDVEVLYSVDTNRPWVVSSGSYSSRFTPIVVQALNNALDQLENRLLLAASEILGVQKSELKIEN
GRVRTISGNKSISVRHLIGTFYWDPAKLKGIEGGLVAVGYYQSPYADDIKEGKINSSISYGCMGHVVEVLMDETEIPRIS
RYVVVHDAGRILNENFARGQIIGSTFHGIEVSLYASLEYNEEGIPITQTFAEYGAMTAMESPKVEIEHLESDSNHLAGLG
EGGTMAAPPAVFNAIRSLVEVKNIPLFLELTSKRK
>Mature_755_residues
MFKEGLRFVKGEGNYIDDFVLKEVKNYFSASIVRSPYAHAMIRSIDKSDAEKLNGVIKVITFNDIRNLLDPFPLSLDVNL
DFYPMAREKTLYYGEPVAVIIAKDDYVAEDAKELLQIDYEPLESIVSIENAINSGPIHPTLKSNVILDKTLVYGRFEYEI
KKSPILIEERIRFPRYSSSPLETYEILARYNGEEYEIFSNFQGPFTIHYLLTKALKSKVVLKGPRDIGGSFGIKSAIYPY
MALIAVASRVVKRPVKWVETRSEHITSSSVGAERESLIRIYGDKDGIINAIEMDLVDNLGAYPRPPEPGNLLRNHGNLTG
AYDIKGLKVRYRAVLTNTVPTGLNRGYGGPHLYFALETVIDSFAREIGMDPIDVRLKNVFKKTPYETLTGGKYNGFSCYS
VLKRMKEIYEKIEGEKRGKVGIGVSLVVEPSGTNIGYLDLARESKDYLPKSAAQDIVIVQIDPYGKVKVMVNGTNEGQGH
ETIISEIVSKRLGVNPDDVEVLYSVDTNRPWVVSSGSYSSRFTPIVVQALNNALDQLENRLLLAASEILGVQKSELKIEN
GRVRTISGNKSISVRHLIGTFYWDPAKLKGIEGGLVAVGYYQSPYADDIKEGKINSSISYGCMGHVVEVLMDETEIPRIS
RYVVVHDAGRILNENFARGQIIGSTFHGIEVSLYASLEYNEEGIPITQTFAEYGAMTAMESPKVEIEHLESDSNHLAGLG
EGGTMAAPPAVFNAIRSLVEVKNIPLFLELTSKRK

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=781, Percent_Identity=25.4801536491677, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI91823271, Length=697, Percent_Identity=23.8163558106169, Blast_Score=103, Evalue=7e-22,
Organism=Escherichia coli, GI1789230, Length=786, Percent_Identity=24.4274809160305, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1789246, Length=796, Percent_Identity=23.7437185929648, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI1786478, Length=754, Percent_Identity=25.4641909814324, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=777, Percent_Identity=23.4234234234234, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737937, Length=392, Percent_Identity=26.530612244898, Blast_Score=98, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 84055; Mature: 84055

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEGLRFVKGEGNYIDDFVLKEVKNYFSASIVRSPYAHAMIRSIDKSDAEKLNGVIKVI
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCEEEEE
TFNDIRNLLDPFPLSLDVNLDFYPMAREKTLYYGEPVAVIIAKDDYVAEDAKELLQIDYE
EHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCHH
PLESIVSIENAINSGPIHPTLKSNVILDKTLVYGRFEYEIKKSPILIEERIRFPRYSSSP
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEEEEECCCCEEEHHHCCCCCCCCCC
LETYEILARYNGEEYEIFSNFQGPFTIHYLLTKALKSKVVLKGPRDIGGSFGIKSAIYPY
HHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEECCHHCCCCCCHHHHHHHH
MALIAVASRVVKRPVKWVETRSEHITSSSVGAERESLIRIYGDKDGIINAIEMDLVDNLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHCCC
AYPRPPEPGNLLRNHGNLTGAYDIKGLKVRYRAVLTNTVPTGLNRGYGGPHLYFALETVI
CCCCCCCCCHHHHCCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
DSFAREIGMDPIDVRLKNVFKKTPYETLTGGKYNGFSCYSVLKRMKEIYEKIEGEKRGKV
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
GIGVSLVVEPSGTNIGYLDLARESKDYLPKSAAQDIVIVQIDPYGKVKVMVNGTNEGQGH
EEEEEEEEECCCCCEEEEEECCCCHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCH
ETIISEIVSKRLGVNPDDVEVLYSVDTNRPWVVSSGSYSSRFTPIVVQALNNALDQLENR
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LLLAASEILGVQKSELKIENGRVRTISGNKSISVRHLIGTFYWDPAKLKGIEGGLVAVGY
HHHHHHHHHCCCHHHEEEECCEEEEECCCCCEEEEEEEHHHEECHHHCCCCCCCEEEEEE
YQSPYADDIKEGKINSSISYGCMGHVVEVLMDETEIPRISRYVVVHDAGRILNENFARGQ
CCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHCCCCCCCE
IIGSTFHGIEVSLYASLEYNEEGIPITQTFAEYGAMTAMESPKVEIEHLESDSNHLAGLG
EECCEECCEEEEEEEEEEECCCCCCHHHHHHHHCCHHCCCCCCEEEEEECCCCCCEEECC
EGGTMAAPPAVFNAIRSLVEVKNIPLFLELTSKRK
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MFKEGLRFVKGEGNYIDDFVLKEVKNYFSASIVRSPYAHAMIRSIDKSDAEKLNGVIKVI
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCEEEEE
TFNDIRNLLDPFPLSLDVNLDFYPMAREKTLYYGEPVAVIIAKDDYVAEDAKELLQIDYE
EHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCHH
PLESIVSIENAINSGPIHPTLKSNVILDKTLVYGRFEYEIKKSPILIEERIRFPRYSSSP
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEEEEECCCCEEEHHHCCCCCCCCCC
LETYEILARYNGEEYEIFSNFQGPFTIHYLLTKALKSKVVLKGPRDIGGSFGIKSAIYPY
HHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEECCHHCCCCCCHHHHHHHH
MALIAVASRVVKRPVKWVETRSEHITSSSVGAERESLIRIYGDKDGIINAIEMDLVDNLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHCCC
AYPRPPEPGNLLRNHGNLTGAYDIKGLKVRYRAVLTNTVPTGLNRGYGGPHLYFALETVI
CCCCCCCCCHHHHCCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
DSFAREIGMDPIDVRLKNVFKKTPYETLTGGKYNGFSCYSVLKRMKEIYEKIEGEKRGKV
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
GIGVSLVVEPSGTNIGYLDLARESKDYLPKSAAQDIVIVQIDPYGKVKVMVNGTNEGQGH
EEEEEEEEECCCCCEEEEEECCCCHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCH
ETIISEIVSKRLGVNPDDVEVLYSVDTNRPWVVSSGSYSSRFTPIVVQALNNALDQLENR
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LLLAASEILGVQKSELKIENGRVRTISGNKSISVRHLIGTFYWDPAKLKGIEGGLVAVGY
HHHHHHHHHCCCHHHEEEECCEEEEECCCCCEEEEEEEHHHEECHHHCCCCCCCEEEEEE
YQSPYADDIKEGKINSSISYGCMGHVVEVLMDETEIPRISRYVVVHDAGRILNENFARGQ
CCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHCCCCCCCE
IIGSTFHGIEVSLYASLEYNEEGIPITQTFAEYGAMTAMESPKVEIEHLESDSNHLAGLG
EECCEECCEEEEEEEEEEECCCCCCHHHHHHHHCCHHCCCCCCEEEEEECCCCCCEEECC
EGGTMAAPPAVFNAIRSLVEVKNIPLFLELTSKRK
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]