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The map label for this gene is uxaA [H]

Identifier: 227826821

GI number: 227826821

Start: 378713

End: 379879

Strand: Direct

Name: uxaA [H]

Synonym: M1425_0435

Alternate gene names: 227826821

Gene position: 378713-379879 (Clockwise)

Preceding gene: 227826820

Following gene: 227826822

Centisome position: 14.52

GC content: 40.62

Gene sequence:

>1167_bases
ATGGAGAAAAAGCCAGTAATAAAGGGTTACATTAGGGAAAATGGTAGCGTTGGAGTTAGAAATTACGTAACCGTAATACC
GGTAGATGACCTATCTAATTCCGCTGCAATAGGAGTATCGAAACTAATTAGGGGTACTGTTGCAATTCCTCATCCATATG
GTAGGTTACAATTTGGTAAAGACTTAGATTTACTCTTCCACGTTCTATCTGGGACTGGTGCAAACCCAAACGTAGCTGGA
GCAATAGTTATTGGGATTGAGGAGAACTGGGCAAATAAGGTAGCTAATAAAATAGCTGAGACTGGAAAACCAGTCGAGGT
TTTCCCTATTGAGGGAAATGGCGATTTGAGAGTAATTGAAAAGGCGAGTAGAAAGGCAAAGGAGATGGTTCAAGAGGCTA
GTGAGAAACAGAGGACAGAAGTTGATCTATCCTCTTTAGTTATGAGTATTAAGTGTGGGGAGAGCGATACTACGTCTGGT
TTGGCATCAAATCCAGCAACTGGGTATGCTGTTGATAAGCTGATTGATTACGGTGCAACAGTATTATTCGGAGAAACGTC
AGAGTTAACTGGTGCTGAGGACATAGTTGCAAGTAGGATACCGGATCCAGTGTTAAGAGAGAAGTTCATGAAGATTTACA
AGGAATATGTGGATTTCATTGAAAGTCAAGGAGTCGATTTATTGGGTTCTCAACCAACTGAGGGGAACATTAAGGGAGGA
TTGTCGACAATAGAGGAAAAAGCTTTAGGAAATATACAAAAGTTGGGTACTAAACCTATAACTTGCGTGCTAGATTATTT
AGACCCATTAGAAAAGAATTCGTCTAGACTATGTTTCGTTAATACCTCATCTGCTGCAGCAGAGGCAGTTACATTGTTTG
CCGCCAAGGGTTCTGTACTTCACTTGTTCACTACTGGTCAAGGGAATGTTGTTGGGCATCCAATAATTCCCGTTGTTAAG
ATTTCGGCAAATCCAAAGACTGTTGCGACAATGAGTGAGCATATTGACGTTGACGTTTCTGACTTACTTCAACTAAAGGT
TAGTTTAAGGGAAGCTGGGGAGAGGATATTCAACTATACGATTAGGGTTGCAAATGGTAGATTAACTTCAGCTGAGCTAT
TACAACACGATGAGTTCTCACCAATAAAGCTTTACATAAGTGCTTGA

Upstream 100 bases:

>100_bases
CAGTGATAAAGTACGGTAGGCCAATAGGATCTGCTATAAAGGAGATTAAGATTGGAGAACACGTACACGTACATAATATA
AGATCTAACAGGTGGGGAAA

Downstream 100 bases:

>100_bases
GAATGAAGGTAAAACCTTTTTCTTTATCTATACCCTTTAATACTAATCCTCCCTCTGATTGGAAGGATACGTGGGATGTG
CAACTATACGTTAAAGTTGA

Product: D-galactarate dehydratase/altronate hydrolase domain protein

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MEKKPVIKGYIRENGSVGVRNYVTVIPVDDLSNSAAIGVSKLIRGTVAIPHPYGRLQFGKDLDLLFHVLSGTGANPNVAG
AIVIGIEENWANKVANKIAETGKPVEVFPIEGNGDLRVIEKASRKAKEMVQEASEKQRTEVDLSSLVMSIKCGESDTTSG
LASNPATGYAVDKLIDYGATVLFGETSELTGAEDIVASRIPDPVLREKFMKIYKEYVDFIESQGVDLLGSQPTEGNIKGG
LSTIEEKALGNIQKLGTKPITCVLDYLDPLEKNSSRLCFVNTSSAAAEAVTLFAAKGSVLHLFTTGQGNVVGHPIIPVVK
ISANPKTVATMSEHIDVDVSDLLQLKVSLREAGERIFNYTIRVANGRLTSAELLQHDEFSPIKLYISA

Sequences:

>Translated_388_residues
MEKKPVIKGYIRENGSVGVRNYVTVIPVDDLSNSAAIGVSKLIRGTVAIPHPYGRLQFGKDLDLLFHVLSGTGANPNVAG
AIVIGIEENWANKVANKIAETGKPVEVFPIEGNGDLRVIEKASRKAKEMVQEASEKQRTEVDLSSLVMSIKCGESDTTSG
LASNPATGYAVDKLIDYGATVLFGETSELTGAEDIVASRIPDPVLREKFMKIYKEYVDFIESQGVDLLGSQPTEGNIKGG
LSTIEEKALGNIQKLGTKPITCVLDYLDPLEKNSSRLCFVNTSSAAAEAVTLFAAKGSVLHLFTTGQGNVVGHPIIPVVK
ISANPKTVATMSEHIDVDVSDLLQLKVSLREAGERIFNYTIRVANGRLTSAELLQHDEFSPIKLYISA
>Mature_388_residues
MEKKPVIKGYIRENGSVGVRNYVTVIPVDDLSNSAAIGVSKLIRGTVAIPHPYGRLQFGKDLDLLFHVLSGTGANPNVAG
AIVIGIEENWANKVANKIAETGKPVEVFPIEGNGDLRVIEKASRKAKEMVQEASEKQRTEVDLSSLVMSIKCGESDTTSG
LASNPATGYAVDKLIDYGATVLFGETSELTGAEDIVASRIPDPVLREKFMKIYKEYVDFIESQGVDLLGSQPTEGNIKGG
LSTIEEKALGNIQKLGTKPITCVLDYLDPLEKNSSRLCFVNTSSAAAEAVTLFAAKGSVLHLFTTGQGNVVGHPIIPVVK
ISANPKTVATMSEHIDVDVSDLLQLKVSLREAGERIFNYTIRVANGRLTSAELLQHDEFSPIKLYISA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=391, Percent_Identity=26.5984654731458, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789516, Length=391, Percent_Identity=26.0869565217391, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 41727; Mature: 41727

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKPVIKGYIRENGSVGVRNYVTVIPVDDLSNSAAIGVSKLIRGTVAIPHPYGRLQFGK
CCCCCCEEHEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCEECCCCCCCCCCCC
DLDLLFHVLSGTGANPNVAGAIVIGIEENWANKVANKIAETGKPVEVFPIEGNGDLRVIE
CHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
KASRKAKEMVQEASEKQRTEVDLSSLVMSIKCGESDTTSGLASNPATGYAVDKLIDYGAT
HHHHHHHHHHHHHHHHHHHHHCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCE
VLFGETSELTGAEDIVASRIPDPVLREKFMKIYKEYVDFIESQGVDLLGSQPTEGNIKGG
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
LSTIEEKALGNIQKLGTKPITCVLDYLDPLEKNSSRLCFVNTSSAAAEAVTLFAAKGSVL
HHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHEEEEEECCCEE
HLFTTGQGNVVGHPIIPVVKISANPKTVATMSEHIDVDVSDLLQLKVSLREAGERIFNYT
EEEECCCCCEECCCCCEEEEECCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHEEEE
IRVANGRLTSAELLQHDEFSPIKLYISA
EEEECCCCCHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MEKKPVIKGYIRENGSVGVRNYVTVIPVDDLSNSAAIGVSKLIRGTVAIPHPYGRLQFGK
CCCCCCEEHEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCEECCCCCCCCCCCC
DLDLLFHVLSGTGANPNVAGAIVIGIEENWANKVANKIAETGKPVEVFPIEGNGDLRVIE
CHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHH
KASRKAKEMVQEASEKQRTEVDLSSLVMSIKCGESDTTSGLASNPATGYAVDKLIDYGAT
HHHHHHHHHHHHHHHHHHHHHCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCE
VLFGETSELTGAEDIVASRIPDPVLREKFMKIYKEYVDFIESQGVDLLGSQPTEGNIKGG
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
LSTIEEKALGNIQKLGTKPITCVLDYLDPLEKNSSRLCFVNTSSAAAEAVTLFAAKGSVL
HHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHEEEEEECCCEE
HLFTTGQGNVVGHPIIPVVKISANPKTVATMSEHIDVDVSDLLQLKVSLREAGERIFNYT
EEEECCCCCEECCCCCEEEEECCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHEEEE
IRVANGRLTSAELLQHDEFSPIKLYISA
EEEECCCCCHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]