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The map label for this gene is glpK2 [H]

Identifier: 227826720

GI number: 227826720

Start: 278689

End: 279285

Strand: Direct

Name: glpK2 [H]

Synonym: M1425_0315

Alternate gene names: 227826720

Gene position: 278689-279285 (Clockwise)

Preceding gene: 227826717

Following gene: 227826725

Centisome position: 10.68

GC content: 38.69

Gene sequence:

>597_bases
GTGCCTAATAGCTTCATCTTGGCAATAGATGAGGGAACAACAAGTGCTAGGGCAATAATCTACAATCAAGATTTAGAAAT
AGTAGGAATAGGTCAACACGAGTTCCCTCAGCATTATCCACAACCAGGGTATGTTGAACATAACCCCCATGAGATATGGA
ATTCACAAATGCTGGCCATAAAGGAGGCGATGGAAAAGTCAAACATTGAGGGCAAGCAGATTACCGGAATTGGAGTGACC
AATCAGAGGGAGACTATAATACTGTGGGATGTAAAAAGTGGAAAGCCGATTTACAATGCAATAGTTTGGCAAGATAGAAG
AACTTCACATACAACAGATTGGCTAAAGGCAAATTACTTTAGGATGATTAAGGATAAAACGGGGCTAGTTCCAGACCCTT
ATTTTAGCGCATCCAAGATAAAGTGGATATTGGATAACGTTCCTAATGCAAGGGAAAAGGCTGAAAGAGGAGAAATAAAG
TTTGGAACTGTAGATACGTATCTAATATGGAAATTAACTAATGGGAAAGTTCACATAGCTGATTATTCAAACGCCTCAAG
AATCGTGTTATTTAATGAATCCTATCTGTTTCGTTAA

Upstream 100 bases:

>100_bases
TAAAATGTATCTAGTAATCAATATTACTTAGATATAAATCCAAATATCTTCCCAAAATGATCTAAAAGAGTTAAATATTA
GTTAAACAAATAATTTTATT

Downstream 100 bases:

>100_bases
TATTGGAAAGTAAAATACGCCAAGTACTGATCCAACTCTACTAATTTCAGTAGCAAATCCTTGCCCAACCGCCCTAACTG
GAGTTGGATATAGTTCAGTT

Product: carbohydrate kinase FGGY

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MPNSFILAIDEGTTSARAIIYNQDLEIVGIGQHEFPQHYPQPGYVEHNPHEIWNSQMLAIKEAMEKSNIEGKQITGIGVT
NQRETIILWDVKSGKPIYNAIVWQDRRTSHTTDWLKANYFRMIKDKTGLVPDPYFSASKIKWILDNVPNAREKAERGEIK
FGTVDTYLIWKLTNGKVHIADYSNASRIVLFNESYLFR

Sequences:

>Translated_198_residues
MPNSFILAIDEGTTSARAIIYNQDLEIVGIGQHEFPQHYPQPGYVEHNPHEIWNSQMLAIKEAMEKSNIEGKQITGIGVT
NQRETIILWDVKSGKPIYNAIVWQDRRTSHTTDWLKANYFRMIKDKTGLVPDPYFSASKIKWILDNVPNAREKAERGEIK
FGTVDTYLIWKLTNGKVHIADYSNASRIVLFNESYLFR
>Mature_197_residues
PNSFILAIDEGTTSARAIIYNQDLEIVGIGQHEFPQHYPQPGYVEHNPHEIWNSQMLAIKEAMEKSNIEGKQITGIGVTN
QRETIILWDVKSGKPIYNAIVWQDRRTSHTTDWLKANYFRMIKDKTGLVPDPYFSASKIKWILDNVPNAREKAERGEIKF
GTVDTYLIWKLTNGKVHIADYSNASRIVLFNESYLFR

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=200, Percent_Identity=43, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI4504007, Length=200, Percent_Identity=43, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI42794763, Length=200, Percent_Identity=43, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI41393575, Length=198, Percent_Identity=41.9191919191919, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI88196792, Length=205, Percent_Identity=31.219512195122, Blast_Score=117, Evalue=5e-27,
Organism=Escherichia coli, GI1790361, Length=189, Percent_Identity=55.026455026455, Blast_Score=232, Evalue=1e-62,
Organism=Escherichia coli, GI1790005, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535599, Length=196, Percent_Identity=43.3673469387755, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321755, Length=174, Percent_Identity=36.7816091954023, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17864214, Length=208, Percent_Identity=40.8653846153846, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24655555, Length=197, Percent_Identity=40.6091370558376, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24655560, Length=197, Percent_Identity=40.6091370558376, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24655570, Length=197, Percent_Identity=40.6091370558376, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24655574, Length=197, Percent_Identity=40.6091370558376, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24655565, Length=197, Percent_Identity=40.6091370558376, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24654573, Length=133, Percent_Identity=43.609022556391, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922058, Length=192, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24652871, Length=159, Percent_Identity=35.2201257861635, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24656367, Length=200, Percent_Identity=26.5, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357867, Length=116, Percent_Identity=31.8965517241379, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 22828; Mature: 22697

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNSFILAIDEGTTSARAIIYNQDLEIVGIGQHEFPQHYPQPGYVEHNPHEIWNSQMLAI
CCCCEEEEEECCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHHHH
KEAMEKSNIEGKQITGIGVTNQRETIILWDVKSGKPIYNAIVWQDRRTSHTTDWLKANYF
HHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHE
RMIKDKTGLVPDPYFSASKIKWILDNVPNAREKAERGEIKFGTVDTYLIWKLTNGKVHIA
EEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCEEEEEEEEEEEEEEECCEEEEE
DYSNASRIVLFNESYLFR
ECCCCCEEEEECCCEECC
>Mature Secondary Structure 
PNSFILAIDEGTTSARAIIYNQDLEIVGIGQHEFPQHYPQPGYVEHNPHEIWNSQMLAI
CCCEEEEEECCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHHHH
KEAMEKSNIEGKQITGIGVTNQRETIILWDVKSGKPIYNAIVWQDRRTSHTTDWLKANYF
HHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHE
RMIKDKTGLVPDPYFSASKIKWILDNVPNAREKAERGEIKFGTVDTYLIWKLTNGKVHIA
EEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCEEEEEEEEEEEEEEECCEEEEE
DYSNASRIVLFNESYLFR
ECCCCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]