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The map label for this gene is sucD2 [H]

Identifier: 227826684

GI number: 227826684

Start: 240478

End: 241260

Strand: Direct

Name: sucD2 [H]

Synonym: M1425_0276

Alternate gene names: 227826684

Gene position: 240478-241260 (Clockwise)

Preceding gene: 227826683

Following gene: 227826686

Centisome position: 9.22

GC content: 40.36

Gene sequence:

>783_bases
ATGTTAAAATACGGTACAAAAATAGTTGCTGGTGTTACTCCGGGTAAGGGAGGAACTCAAGTTAACAATGTTCCAGTTTA
CGATACGGTAAAGGATGCAATGAAAGAGCATGAGGCAGATACTTCAATAATTTTCGTTCCAGCCAGATACGCAGTGGATG
CCATATATGAGGCAGTTGATGCGGGGATAAAATTAATTGTAACTATAACCGAGCACATACCGGTTTTGGACATGGCTAGA
GCTATAAAGTATGCCAAAGCTAGGGGAGCTAGAATAATAGGACCCAATTGTCCTGGAATAATAGCTCCAGAGGAAAGTCT
AGTTGGAATACTTCCAGCCAGAGCATTTAAGAAGGGTAAAATAGGAATAGTGTCTAGATCAGGTACACTAACATATGAGG
TTTCAGAGTTACTTAAGAACTCTGGTATGGGCCAATCTACTGTTATAGGTATAGGAGGGGATCCAATAATAGGTACGAGT
ACTTTAGAAGTTGCAAAGATGTTTGATCAAGATCCAGAGACGGAAAAAATTGTTGTAATAGGAGAAATAGGTGGTACCAT
GGAGGAGAGGTTAGCAGAGGCGTATAAGAGGGGAGAAATTAAGAAACCAATTATAGCTTACATAGCAGGAATGACTGCAC
CTAGGGAGAAAAGGATGGGACATGCAGGAGCAGTAGTTTATATGGGTATGGGTACATTCGAGAGTAAAATAAGGGCATTT
AAAGAAGCTGGAATTCCAATAGCTAATACCCCCTACGATATCCCCAAGTTACTTCTTTCTTAA

Upstream 100 bases:

>100_bases
TATTAAAAATGATAGGTGATGCAGTACGCTCATAAATAAGAATACTAGGGTAATTGTCCAGGGAATAACCGGAAGAGAAG
GGAGCTTCCATACACAGCAA

Downstream 100 bases:

>100_bases
CATATAAGTAGCTGTAATTACAACTGCAACTACTATAACTGCAGATAATGCGTAGAGTAGGGAGAACCCATGACCAACAC
CGTTATTTTTTATGTTAATA

Product: ATP-citrate lyase/succinyl-CoA ligase

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha 2; SCS-alpha 2 [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLKYGTKIVAGVTPGKGGTQVNNVPVYDTVKDAMKEHEADTSIIFVPARYAVDAIYEAVDAGIKLIVTITEHIPVLDMAR
AIKYAKARGARIIGPNCPGIIAPEESLVGILPARAFKKGKIGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTS
TLEVAKMFDQDPETEKIVVIGEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAF
KEAGIPIANTPYDIPKLLLS

Sequences:

>Translated_260_residues
MLKYGTKIVAGVTPGKGGTQVNNVPVYDTVKDAMKEHEADTSIIFVPARYAVDAIYEAVDAGIKLIVTITEHIPVLDMAR
AIKYAKARGARIIGPNCPGIIAPEESLVGILPARAFKKGKIGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTS
TLEVAKMFDQDPETEKIVVIGEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAF
KEAGIPIANTPYDIPKLLLS
>Mature_260_residues
MLKYGTKIVAGVTPGKGGTQVNNVPVYDTVKDAMKEHEADTSIIFVPARYAVDAIYEAVDAGIKLIVTITEHIPVLDMAR
AIKYAKARGARIIGPNCPGIIAPEESLVGILPARAFKKGKIGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTS
TLEVAKMFDQDPETEKIVVIGEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAF
KEAGIPIANTPYDIPKLLLS

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=257, Percent_Identity=48.2490272373541, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI38569421, Length=235, Percent_Identity=33.6170212765957, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI38569423, Length=235, Percent_Identity=33.6170212765957, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786949, Length=257, Percent_Identity=52.1400778210117, Blast_Score=262, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17550194, Length=255, Percent_Identity=47.0588235294118, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17553126, Length=255, Percent_Identity=47.0588235294118, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17557344, Length=244, Percent_Identity=29.0983606557377, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17551266, Length=214, Percent_Identity=28.5046728971963, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324716, Length=266, Percent_Identity=42.8571428571429, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21356559, Length=262, Percent_Identity=44.2748091603053, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28574296, Length=255, Percent_Identity=46.6666666666667, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI281363475, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363473, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363477, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 27763; Mature: 27763

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYGTKIVAGVTPGKGGTQVNNVPVYDTVKDAMKEHEADTSIIFVPARYAVDAIYEAVD
CCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHH
AGIKLIVTITEHIPVLDMARAIKYAKARGARIIGPNCPGIIAPEESLVGILPARAFKKGK
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
IGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTSTLEVAKMFDQDPETEKIVVI
EEEEECCCEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
GEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAF
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCEEEEEECCHHHHHHHHH
KEAGIPIANTPYDIPKLLLS
HHCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MLKYGTKIVAGVTPGKGGTQVNNVPVYDTVKDAMKEHEADTSIIFVPARYAVDAIYEAVD
CCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHH
AGIKLIVTITEHIPVLDMARAIKYAKARGARIIGPNCPGIIAPEESLVGILPARAFKKGK
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
IGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTSTLEVAKMFDQDPETEKIVVI
EEEEECCCEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
GEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAF
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCEEEEEECCHHHHHHHHH
KEAGIPIANTPYDIPKLLLS
HHCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]