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The map label for this gene is sucC [H]

Identifier: 227826683

GI number: 227826683

Start: 239399

End: 240412

Strand: Direct

Name: sucC [H]

Synonym: M1425_0275

Alternate gene names: 227826683

Gene position: 239399-240412 (Clockwise)

Preceding gene: 227826682

Following gene: 227826684

Centisome position: 9.18

GC content: 36.19

Gene sequence:

>1014_bases
ATGAAATTATACGAATATGAGGGAAAGAGTCTTTTTAAGCGTGTAGGGATACCAGTGCCTAATGGTGTTGTAACTTCTGA
ACCAATAAGATGGCAAGGAAAAGCTGTAGTGAAATCTCAACTATTGGAAGGCGCTAGAGGTAAAAGAGGATTAGTAAGAG
TAACTGAAGACGTTTATAATACTATTTTAGAGCTGAAAAAACTAGGAGTCGAGAAATTCTTAGTAGAGGAGTTTGTTCCT
CACGAGAAGGAGTTTTACGCTTCAGTATTGTTAGATAGGGAAACTGCGGAACCAATGTTAGTTTTATCAAGAGAAGGAGG
CATTGATGTTGAACAAGCTAAGGACGTTAAGAAGATGATAATACCACTAGAGAGGGGAGTTAGGAGTTATGATATTGTTG
AGGCTGAGAAGTATCTAGGAGTTAAGGGATTAGGACAAATAATACAAGGTTTATATAAATTATTTGTAGATTACGACGCT
GAACTAGTTGAGATAAACCCATTAGCATTGACTAATGATGGTAGAATATTAGCTTTAGACTCTAAAGTGATTTTAGAGGA
TAACGCGTTATATAGACATGAGGATTTGTTAAAGGAGTTAGGGAGGCAAGAAGTTCGTGATAGTTATGTGGAACTAGAGG
GAGATATAGGAATAATAGGCAATGGTGCAGGATTAACCATGGCTTCAATGGATCTAGTTAAATTAAATGGCGGAAATCCA
GCAAATTTCTTGGATGTTGGTGGAGGAGCTAATAGGGAACATGTTAAAGAAAGTGTTCTCAAAGTGGGTAGTAATCCTAG
AGTCAAAAAGATTGTTATAAATATTTACGGTGGAATTACTAGATGTGATGAGGTAGCGTTAGGTATAATTGATGCGCTAA
AGGAGGTAAAGAAGCCAATATTTGTTAGATTATTAGGAACTAACGAGGAATTAGGGAAGAAAATATTAAGAGAGAACGGT
GTAAACGTATATGATGATGTATTAAAAATGATAGGTGATGCAGTACGCTCATAA

Upstream 100 bases:

>100_bases
AGAAAATTCCTCGTGATACAAAATAGGCTTCTTTAAATACTTTTACTAAATTTAAGTAATGCATAGTAATGTTTAAATTT
TTATGTGATAAGTATGTGGT

Downstream 100 bases:

>100_bases
ATAAGAATACTAGGGTAATTGTCCAGGGAATAACCGGAAGAGAAGGGAGCTTCCATACACAGCAAATGTTAAAATACGGT
ACAAAAATAGTTGCTGGTGT

Product: succinate--CoA ligase (ADP-forming)

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDVYNTILELKKLGVEKFLVEEFVP
HEKEFYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMIIPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDA
ELVEINPLALTNDGRILALDSKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNP
ANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPIFVRLLGTNEELGKKILRENG
VNVYDDVLKMIGDAVRS

Sequences:

>Translated_337_residues
MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDVYNTILELKKLGVEKFLVEEFVP
HEKEFYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMIIPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDA
ELVEINPLALTNDGRILALDSKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNP
ANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPIFVRLLGTNEELGKKILRENG
VNVYDDVLKMIGDAVRS
>Mature_337_residues
MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDVYNTILELKKLGVEKFLVEEFVP
HEKEFYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMIIPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDA
ELVEINPLALTNDGRILALDSKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNP
ANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPIFVRLLGTNEELGKKILRENG
VNVYDDVLKMIGDAVRS

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=375, Percent_Identity=32.5333333333333, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI157779135, Length=382, Percent_Identity=31.9371727748691, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI294862256, Length=362, Percent_Identity=32.3204419889503, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1786948, Length=371, Percent_Identity=37.466307277628, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17539378, Length=377, Percent_Identity=32.6259946949602, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17567829, Length=389, Percent_Identity=34.1902313624679, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321683, Length=379, Percent_Identity=34.0369393139842, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21356231, Length=377, Percent_Identity=33.6870026525199, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161078106, Length=376, Percent_Identity=35.9042553191489, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24645208, Length=376, Percent_Identity=35.9042553191489, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281361397, Length=377, Percent_Identity=36.0742705570292, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281361395, Length=377, Percent_Identity=36.0742705570292, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 37375; Mature: 37375

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDVYN
CCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHH
TILELKKLGVEKFLVEEFVPHEKEFYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHH
IPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDAELVEINPLALTNDGRILALD
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCEEEEEC
SKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEEECCCCC
ANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPI
CCEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
FVRLLGTNEELGKKILRENGVNVYDDVLKMIGDAVRS
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDVYN
CCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHH
TILELKKLGVEKFLVEEFVPHEKEFYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHH
IPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDAELVEINPLALTNDGRILALD
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCEEEEEC
SKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEEECCCCC
ANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPI
CCEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
FVRLLGTNEELGKKILRENGVNVYDDVLKMIGDAVRS
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA