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The map label for this gene is eIF2B

Identifier: 227826585

GI number: 227826585

Start: 153678

End: 154097

Strand: Direct

Name: eIF2B

Synonym: M1425_0175

Alternate gene names: 227826585

Gene position: 153678-154097 (Clockwise)

Preceding gene: 227826579

Following gene: 227826586

Centisome position: 5.89

GC content: 35.0

Gene sequence:

>420_bases
GTGAGTTCAGAAAAAGAATACGTGGAAATGCTTGATAGACTATACTCAAAATTACCTGAAAAGGGCCGTAAGGAAGGTAC
ACAAGCACTACCTAATCTAATAATATTCAATATAGGAAATACTACCATGATTAGAAACTTTGCGGAATATTGTGATAGAA
TTAGAAGAGAAGATAAAATATGTATGAAATACTTGCTAAAGGAATTGGCTGCACCTGGTAATGTGGACGATAAAGGTGAA
CTTATAATTCAAGGAAAATTTTCCTCACAAGTAATAAATACCTTAATGGAAAGATTTTTGAAGGCATATGTTGAATGTAG
TACTTGTAAAAGCCTAGACACTGTACTAAAGAAGGAGAAGAAGAGCTGGTATATAGTCTGTCTAGCGTGTGGAGCTCAAA
CACCAGTGAAGCCTCTATGA

Upstream 100 bases:

>100_bases
TAAGTATCTGCCCTATTTAATGCACACCCATATGTCTCAACGTAGATGGTTTTCATTTTCTTCAGTAGTATTTTAAACCC
TATGTGCTTATAGATTTAAT

Downstream 100 bases:

>100_bases
AAGTGTTTCTAAATATAATTAGAGCACAAGGCATGACACTGGTAAATATATGTCAAGAGGAACTATTAGGGAAAGTATTC
AGAGAAGGGGAAATAATACT

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKICMKYLLKELAAPGNVDDKGE
LIIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEKKSWYIVCLACGAQTPVKPL

Sequences:

>Translated_139_residues
MSSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKICMKYLLKELAAPGNVDDKGE
LIIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEKKSWYIVCLACGAQTPVKPL
>Mature_138_residues
SSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKICMKYLLKELAAPGNVDDKGEL
IIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEKKSWYIVCLACGAQTPVKPL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family

Homologues:

Organism=Homo sapiens, GI29826335, Length=143, Percent_Identity=28.6713286713287, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508049, Length=98, Percent_Identity=32.6530612244898, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325018, Length=141, Percent_Identity=31.2056737588652, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647377, Length=136, Percent_Identity=30.1470588235294, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2B_SULIA (C3N120)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002842250.1
- GeneID:   7813868
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_0175
- OMA:   FLKCEAC
- ProtClustDB:   PRK03988
- HAMAP:   MF_00232
- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190
- SMART:   SM00653

Pfam domain/function: PF01873 eIF-5_eIF-2B; SSF100966 Transl_init_fac_IF2/IF5_N; SSF75689 Transl_init_fac_IF2/IF5_Zn-bd

EC number: NA

Molecular weight: Translated: 15938; Mature: 15807

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCHHH
CMKYLLKELAAPGNVDDKGELIIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEK
HHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KSWYIVCLACGAQTPVKPL
CCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SSEKEYVEMLDRLYSKLPEKGRKEGTQALPNLIIFNIGNTTMIRNFAEYCDRIRREDKI
CCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCHHH
CMKYLLKELAAPGNVDDKGELIIQGKFSSQVINTLMERFLKAYVECSTCKSLDTVLKKEK
HHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KSWYIVCLACGAQTPVKPL
CCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA