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The map label for this gene is 227826561

Identifier: 227826561

GI number: 227826561

Start: 131131

End: 132492

Strand: Direct

Name: 227826561

Synonym: M1425_0151

Alternate gene names: NA

Gene position: 131131-132492 (Clockwise)

Preceding gene: 227826560

Following gene: 227826563

Centisome position: 5.03

GC content: 38.33

Gene sequence:

>1362_bases
TTGAAAAGAGCCGAATATGATGTTTTAATTATTGGTTTAGGTATAGCTGGTGCATCACTTGCTTGGAAACTATCTCAATC
TAACCTTAAGGTCTTAGCCATAGATAGTAAACCATGGAATAGGTTTGGCGATAAACCTTGTGGAGATGCAATAAGCAAGG
AACATTTCGATAACTTGGGGATGCCTTATCCTCAAGGCAAAGAGTTGGAGGAGAAAGTAGAAGGTATAAAGCTGTATAGC
CCTGACATGAAAACCGTTTGGACGGTAAAAGGAGAAGGTTTTGAAATTGATTCTCCCAGTTATGTACAGAGGTTGACCAA
AGAGGCTAGAGATAGGGGAGTTGAAATTTTAGATCTAACGACTGCGATGAAACCGATAATAGTTGGCAATAAAGTGGAAG
GAGCGGTCTTGTTTAACAGAAGGACTAATGAAACTATAGAGGCTAAAGCTAAAATTACCGTCGATGCTACTGGATATTCA
ACCAGTTTTAGAAGTAAGCTTCCATTTGAATTTCCGGTGACCGAGTCATTAGATGACAAAGACGCTGATGTTGCATATAG
AGAAGTGTTAAATACTAAGGATGAAATTGATGAATATCCGTATTTAAGAATATTCATAACACAGAAGGCTTCTCCGGGAG
GTTATTGGTGGTACTTTCCGAAAGGACCAAATAAGGTCAATGTTGGTTTAGGTATACAGGGAGGCATGGGTTATCCCAGT
ATTCATGAATTCTACAATAAATATGTCGACTATTACGCTCCAGACATAGATAAGAATAGGCTATTAGTTAAAGGTGGAGC
GTTAGTACCTACTAGAAGGCCCCTTGCAACTATCGTATGGGATGGTGTAGCAGTAATAGGTGACTCGGCATTTACAGTGA
ATCCAGTACATGGAGGAGGTAAAGGTTCTGCAATGATTTCAGCTTATTGTGTTGGTAAAGCTATACTTAATGCATTTGAG
AATAATGATTTCTCTGCAAAAGGACTATGGAATGCTAATGAGTGTTATATAGAGAGATATGGTGCTAAGCAAGCTAGCCT
TGACTTATTTAGAAGATTTTTACAGAAGTTAAGTGATGATGAGATAAATTATGGAATGAGTAGGAAAGTGATAAGAGAGG
AGGACTTATTGGAGGCAAGTGCGAATGGTGATCTTCAGCTTTCCACAGCTGAAAAAGCAATGAGAGCTATTATGGCTCTT
GGAAAGCCATCATTACTATTTAAGCTAAAGACTGTTGCCGAGTATATGAAAAAGGTTAAGGATGTTTATAAGCGCTTCCC
AGCAGAGCCTAATGGTTTAATGAAGTGGAAATATAGCGTCGATTCGATAATTTTAGAATTTAATAAGGCTTTGGAAAAGT
AG

Upstream 100 bases:

>100_bases
AATACTTCATAAAGTTCCTAATTCGATAAAGGCAAATATTATAAAGGATTATTGTAAATAATTTTTTATTCTAACGAGGG
AAGTAGATAGTGGTGCTAAA

Downstream 100 bases:

>100_bases
TATAACTACAAGTAAAACATATGGTGCTACTAAGGGAATCCAAAACGTTTTTGAAGTATAACTCCCTACGTCCTCTAGCG
CCTTTAGCATAATAGAAATT

Product: geranylgeranyl reductase

Products: NA

Alternate protein names: DGGGPL reductase; 2,3-di-O-geranylgeranylglyceryl phosphate reductase; Geranylgeranyl reductase; GGR [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKRAEYDVLIIGLGIAGASLAWKLSQSNLKVLAIDSKPWNRFGDKPCGDAISKEHFDNLGMPYPQGKELEEKVEGIKLYS
PDMKTVWTVKGEGFEIDSPSYVQRLTKEARDRGVEILDLTTAMKPIIVGNKVEGAVLFNRRTNETIEAKAKITVDATGYS
TSFRSKLPFEFPVTESLDDKDADVAYREVLNTKDEIDEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPS
IHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGGKGSAMISAYCVGKAILNAFE
NNDFSAKGLWNANECYIERYGAKQASLDLFRRFLQKLSDDEINYGMSRKVIREEDLLEASANGDLQLSTAEKAMRAIMAL
GKPSLLFKLKTVAEYMKKVKDVYKRFPAEPNGLMKWKYSVDSIILEFNKALEK

Sequences:

>Translated_453_residues
MKRAEYDVLIIGLGIAGASLAWKLSQSNLKVLAIDSKPWNRFGDKPCGDAISKEHFDNLGMPYPQGKELEEKVEGIKLYS
PDMKTVWTVKGEGFEIDSPSYVQRLTKEARDRGVEILDLTTAMKPIIVGNKVEGAVLFNRRTNETIEAKAKITVDATGYS
TSFRSKLPFEFPVTESLDDKDADVAYREVLNTKDEIDEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPS
IHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGGKGSAMISAYCVGKAILNAFE
NNDFSAKGLWNANECYIERYGAKQASLDLFRRFLQKLSDDEINYGMSRKVIREEDLLEASANGDLQLSTAEKAMRAIMAL
GKPSLLFKLKTVAEYMKKVKDVYKRFPAEPNGLMKWKYSVDSIILEFNKALEK
>Mature_453_residues
MKRAEYDVLIIGLGIAGASLAWKLSQSNLKVLAIDSKPWNRFGDKPCGDAISKEHFDNLGMPYPQGKELEEKVEGIKLYS
PDMKTVWTVKGEGFEIDSPSYVQRLTKEARDRGVEILDLTTAMKPIIVGNKVEGAVLFNRRTNETIEAKAKITVDATGYS
TSFRSKLPFEFPVTESLDDKDADVAYREVLNTKDEIDEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPS
IHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGGKGSAMISAYCVGKAILNAFE
NNDFSAKGLWNANECYIERYGAKQASLDLFRRFLQKLSDDEINYGMSRKVIREEDLLEASANGDLQLSTAEKAMRAIMAL
GKPSLLFKLKTVAEYMKKVKDVYKRFPAEPNGLMKWKYSVDSIILEFNKALEK

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: NA

Molecular weight: Translated: 50728; Mature: 50728

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAEYDVLIIGLGIAGASLAWKLSQSNLKVLAIDSKPWNRFGDKPCGDAISKEHFDNLG
CCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCCCHHCCCCCCCHHHHHHHHHHCC
MPYPQGKELEEKVEGIKLYSPDMKTVWTVKGEGFEIDSPSYVQRLTKEARDRGVEILDLT
CCCCCCCCHHHHHCCEEEECCCCCEEEEECCCCEECCCCHHHHHHHHHHHHCCCEEEEEH
TAMKPIIVGNKVEGAVLFNRRTNETIEAKAKITVDATGYSTSFRSKLPFEFPVTESLDDK
HHHCCEEECCCCCCEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DADVAYREVLNTKDEIDEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPS
CHHHHHHHHHCCHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCCCH
IHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGG
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCEEEECCCCEEEECCCCCC
KGSAMISAYCVGKAILNAFENNDFSAKGLWNANECYIERYGAKQASLDLFRRFLQKLSDD
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
EINYGMSRKVIREEDLLEASANGDLQLSTAEKAMRAIMALGKPSLLFKLKTVAEYMKKVK
CCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCHHEEEHHHHHHHHHHHH
DVYKRFPAEPNGLMKWKYSVDSIILEFNKALEK
HHHHHCCCCCCCCEEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRAEYDVLIIGLGIAGASLAWKLSQSNLKVLAIDSKPWNRFGDKPCGDAISKEHFDNLG
CCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCCCHHCCCCCCCHHHHHHHHHHCC
MPYPQGKELEEKVEGIKLYSPDMKTVWTVKGEGFEIDSPSYVQRLTKEARDRGVEILDLT
CCCCCCCCHHHHHCCEEEECCCCCEEEEECCCCEECCCCHHHHHHHHHHHHCCCEEEEEH
TAMKPIIVGNKVEGAVLFNRRTNETIEAKAKITVDATGYSTSFRSKLPFEFPVTESLDDK
HHHCCEEECCCCCCEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DADVAYREVLNTKDEIDEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPS
CHHHHHHHHHCCHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCCCH
IHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGG
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCEEEECCCCEEEECCCCCC
KGSAMISAYCVGKAILNAFENNDFSAKGLWNANECYIERYGAKQASLDLFRRFLQKLSDD
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
EINYGMSRKVIREEDLLEASANGDLQLSTAEKAMRAIMALGKPSLLFKLKTVAEYMKKVK
CCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCHHEEEHHHHHHHHHHHH
DVYKRFPAEPNGLMKWKYSVDSIILEFNKALEK
HHHHHCCCCCCCCEEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA