Click here to switch to the map view.

The map label for this gene is xapA [C]

Identifier: 227826550

GI number: 227826550

Start: 123584

End: 124396

Strand: Direct

Name: xapA [C]

Synonym: M1425_0140

Alternate gene names: 227826550

Gene position: 123584-124396 (Clockwise)

Preceding gene: 227826548

Following gene: 227826551

Centisome position: 4.74

GC content: 39.36

Gene sequence:

>813_bases
ATGATTGAGGAAAATGAAAAAGCCTCGATAGGAATTATTGGTGGTTCTGGGTTATATGATCCGGGTATTTTTTCGGAGAG
TAAGGAAAGAAAAGTATATACACCATATGGAGAACCTAGCGATTTAATAACGATAGGTAAAATCGGAAATAAGACTGTAG
CGTTCTTGCCTAGACACGGAAGGAGACATAGAATTCCTCCTCACAAAATAAACTATAGGGCTAATATTTGGGCATTAAAA
GAACTCGGAGTTAGATGGGTGATTTCAGTTTCTGCAGTAGGTAGCTTAAGAATTGACTATAAACCCGGTGATTTTGTTAT
ACCAGATCAATTTATAGATATGACAAAGAAAAGAGATTACACCTTCTTCGATGGCCCCGTAGTAGCTCACGTCTCAATGG
CTGATCCATTTTGTAATAGCTTAAGGAAATTGGCATTAGAGACTGCTAAGGAACTAAATATTAGGACGCATGAAAGTGGT
ACCTACATATGTATTGAAGGTCCTAGGTTTTCTACAAGGGCTGAGAGTAGGACGTGGAGAGAAGTTTACAAGGCTGATAT
AATCGGTATGACGTTAGTACCAGAGGTTAATCTAGCTTGTGAAGCACAAATGTGTTATGCTACTATTGCCATGGTGACTG
ACTACGATGTTTTCGCTGAGATTCCAGTTACAGCAGAGGAGGTCACTAGAGTTATGGCAGAGAATACGGAAAAGGCTAAG
AAACTTTTATATGCGTTAATTCAAAGGTTACCAGAAAAACCAGAAGAGGGGTCGTGTTCCTGTTGCAACAGTCTGAAGAC
AGCACTAGTATAA

Upstream 100 bases:

>100_bases
ACTGGTATTTTGGGCAAAATTAACTCCCTAAAAAATCTCTGTTAAAACTTTATCAATTTTTTGGTTTATACTTTATAAGG
TACGTTAATGTATTTCACTT

Downstream 100 bases:

>100_bases
GAAAATTGGTGAAGTTTTTAAACATTAATTTTCCGCAAATAGATTTAATAGTATATGGTCGTGGTCTTGAACTCCCTTCA
TTTACTCTTGCAAGAGCTCT

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MIEENEKASIGIIGGSGLYDPGIFSESKERKVYTPYGEPSDLITIGKIGNKTVAFLPRHGRRHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRIDYKPGDFVIPDQFIDMTKKRDYTFFDGPVVAHVSMADPFCNSLRKLALETAKELNIRTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQRLPEKPEEGSCSCCNSLKTALV

Sequences:

>Translated_270_residues
MIEENEKASIGIIGGSGLYDPGIFSESKERKVYTPYGEPSDLITIGKIGNKTVAFLPRHGRRHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRIDYKPGDFVIPDQFIDMTKKRDYTFFDGPVVAHVSMADPFCNSLRKLALETAKELNIRTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQRLPEKPEEGSCSCCNSLKTALV
>Mature_270_residues
MIEENEKASIGIIGGSGLYDPGIFSESKERKVYTPYGEPSDLITIGKIGNKTVAFLPRHGRRHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRIDYKPGDFVIPDQFIDMTKKRDYTFFDGPVVAHVSMADPFCNSLRKLALETAKELNIRTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQRLPEKPEEGSCSCCNSLKTALV

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=51.6129032258064, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71980569, Length=240, Percent_Identity=44.1666666666667, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17541190, Length=277, Percent_Identity=24.5487364620939, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323045, Length=265, Percent_Identity=36.2264150943396, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=43.956043956044, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI221459247, Length=248, Percent_Identity=39.9193548387097, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30301; Mature: 30301

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEENEKASIGIIGGSGLYDPGIFSESKERKVYTPYGEPSDLITIGKIGNKTVAFLPRHG
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEEEEECCCC
RRHRIPPHKINYRANIWALKELGVRWVISVSAVGSLRIDYKPGDFVIPDQFIDMTKKRDY
CCCCCCCCEECEEEEEEEHHHCCEEEEEEEEEEEEEEEEECCCCEECCHHHHHHHHCCCC
TFFDGPVVAHVSMADPFCNSLRKLALETAKELNIRTHESGTYICIEGPRFSTRAESRTWR
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHH
EVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
HHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCHHHHH
KLLYALIQRLPEKPEEGSCSCCNSLKTALV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIEENEKASIGIIGGSGLYDPGIFSESKERKVYTPYGEPSDLITIGKIGNKTVAFLPRHG
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEEEEECCCC
RRHRIPPHKINYRANIWALKELGVRWVISVSAVGSLRIDYKPGDFVIPDQFIDMTKKRDY
CCCCCCCCEECEEEEEEEHHHCCEEEEEEEEEEEEEEEEECCCCEECCHHHHHHHHCCCC
TFFDGPVVAHVSMADPFCNSLRKLALETAKELNIRTHESGTYICIEGPRFSTRAESRTWR
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHH
EVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
HHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCHHHHH
KLLYALIQRLPEKPEEGSCSCCNSLKTALV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]