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The map label for this gene is czcD [H]

Identifier: 227826472

GI number: 227826472

Start: 51092

End: 51910

Strand: Direct

Name: czcD [H]

Synonym: M1425_0061

Alternate gene names: 227826472

Gene position: 51092-51910 (Clockwise)

Preceding gene: 227826471

Following gene: 227826478

Centisome position: 1.96

GC content: 33.94

Gene sequence:

>819_bases
GTGCAAAGAACTTTTATATTGACGTTGTTTACGTCCCTTAGTTTTATTATAGCTTACTATATTTCCCTTAGTCCATTAAT
TTTAGCAGAATTTTCTCACGCCTTAATTGACTTCTTAACAATTACATTTTCAATTATCGCCCTAAAATTTATAGGGGAGA
ATGAAGTAAGTGAGGGGAGGCTTTCTTATGGATTACATAGACTGGAAGTCATTGTTGCTATGATTAATATCTTTGCTATT
ATCCTCCTTTCACTTATTGTAGCATATACTTCCATAACGTCCTTGTTAAAAGAGACTACTAACAGTTCTTTTGCTTTGAT
TATCTCGTCAGCCCTAGCATCAATTCTAACTTTCTTTGCATCTCCTAAAGAAAAGGACAACTTGGGTAAGAGGGGATTAT
ATGTGCATATAATATCAGACTTTCTAGGATATATAATCAGCTTTGTTATAGGTATTCTTATCCTTATTTCCGGAATACGT
GAATTGGATCCCGTAGGAGCAATTATACTTGTAATACTAAATTTTGCACTTGCAATCCCATTATTAAAGGAATCTTTTTT
AATATTTATGGAAGGTTCTCCAGTGAAAATTGATAATATCATGGGAGAACTTACAAAAATTTCTCCAGATATTCATCATT
TACATGTGTGGTCAATTTGTGATCATGTAAAGGTAGCAACACTTCACGTTAAAGCATCTCCAAATCTGACTATAGCTGAG
GCGGATAAGATAAGGGGTTCAATCTGTAGTCTGCTTAGAGAAAAATATGGCATTTCTCATGTAACGGTTCAGTTTGAGAC
GACGAATGATGACGATTAA

Upstream 100 bases:

>100_bases
GTTCCACGTTAACTCAGATAAAAATTGAACGAATCAACAAAGCATCTCTTAGGGTAAACCTTAAAAAGACTTATTTATAG
TATTCATCTATCTCTTCATT

Downstream 100 bases:

>100_bases
TAAAACTGGCTGGGCCACCACTCAATATCTTTGTGAAGTTTACTTCCCATTAACTTTATTATTTTTTCCCTATCCATCCT
TGAAAATCTAACGTCTATAT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MQRTFILTLFTSLSFIIAYYISLSPLILAEFSHALIDFLTITFSIIALKFIGENEVSEGRLSYGLHRLEVIVAMINIFAI
ILLSLIVAYTSITSLLKETTNSSFALIISSALASILTFFASPKEKDNLGKRGLYVHIISDFLGYIISFVIGILILISGIR
ELDPVGAIILVILNFALAIPLLKESFLIFMEGSPVKIDNIMGELTKISPDIHHLHVWSICDHVKVATLHVKASPNLTIAE
ADKIRGSICSLLREKYGISHVTVQFETTNDDD

Sequences:

>Translated_272_residues
MQRTFILTLFTSLSFIIAYYISLSPLILAEFSHALIDFLTITFSIIALKFIGENEVSEGRLSYGLHRLEVIVAMINIFAI
ILLSLIVAYTSITSLLKETTNSSFALIISSALASILTFFASPKEKDNLGKRGLYVHIISDFLGYIISFVIGILILISGIR
ELDPVGAIILVILNFALAIPLLKESFLIFMEGSPVKIDNIMGELTKISPDIHHLHVWSICDHVKVATLHVKASPNLTIAE
ADKIRGSICSLLREKYGISHVTVQFETTNDDD
>Mature_272_residues
MQRTFILTLFTSLSFIIAYYISLSPLILAEFSHALIDFLTITFSIIALKFIGENEVSEGRLSYGLHRLEVIVAMINIFAI
ILLSLIVAYTSITSLLKETTNSSFALIISSALASILTFFASPKEKDNLGKRGLYVHIISDFLGYIISFVIGILILISGIR
ELDPVGAIILVILNFALAIPLLKESFLIFMEGSPVKIDNIMGELTKISPDIHHLHVWSICDHVKVATLHVKASPNLTIAE
ADKIRGSICSLLREKYGISHVTVQFETTNDDD

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=278, Percent_Identity=20.5035971223022, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=262, Percent_Identity=26.3358778625954, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193210990, Length=292, Percent_Identity=21.5753424657534, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 30098; Mature: 30098

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTFILTLFTSLSFIIAYYISLSPLILAEFSHALIDFLTITFSIIALKFIGENEVSEGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
LSYGLHRLEVIVAMINIFAIILLSLIVAYTSITSLLKETTNSSFALIISSALASILTFFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
SPKEKDNLGKRGLYVHIISDFLGYIISFVIGILILISGIRELDPVGAIILVILNFALAIP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LLKESFLIFMEGSPVKIDNIMGELTKISPDIHHLHVWSICDHVKVATLHVKASPNLTIAE
HHHCCEEEEECCCCEEHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEEH
ADKIRGSICSLLREKYGISHVTVQFETTNDDD
HHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
>Mature Secondary Structure
MQRTFILTLFTSLSFIIAYYISLSPLILAEFSHALIDFLTITFSIIALKFIGENEVSEGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
LSYGLHRLEVIVAMINIFAIILLSLIVAYTSITSLLKETTNSSFALIISSALASILTFFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
SPKEKDNLGKRGLYVHIISDFLGYIISFVIGILILISGIRELDPVGAIILVILNFALAIP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LLKESFLIFMEGSPVKIDNIMGELTKISPDIHHLHVWSICDHVKVATLHVKASPNLTIAE
HHHCCEEEEECCCCEEHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCEEEEH
ADKIRGSICSLLREKYGISHVTVQFETTNDDD
HHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]