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The map label for this gene is nprB [H]

Identifier: 227817814

GI number: 227817814

Start: 4790245

End: 4791894

Strand: Reverse

Name: nprB [H]

Synonym: BAMEG_5335

Alternate gene names: 227817814

Gene position: 4791894-4790245 (Counterclockwise)

Preceding gene: 227817815

Following gene: 227817810

Centisome position: 91.62

GC content: 36.61

Gene sequence:

>1650_bases
GTGAAAAAGCAAGTCATTTCATCAGCATTAGCGTTAACTGTTATCGCCGGGGGATTTGGAACATTTGGAGCAACGACAAC
GAAAGCGGAAGAACAAAAAATTCAATATCATCAAGAATTTAAAACGCCTGCATACATAGGTGAAGAATGGAAAGCACCGG
AAGGACTAGATAAAAAAGAGACAGTCTTTCAATATTTAGAGAGTAAAAAAGACATGTTTAAATTAGCAGGAAATATTGAT
AAACATTTCAATGTCGTTGGGGAAGAAAAAGATGCTGAATCTGGCACAACACACGTGAAGCTAGTTGAGAAACATAATAA
CATTCCTGTGTATGGTTCAGACCAAACTGTTACACTAGATAAAGAAAATAATGTAAAAGCATTCTTCGGACAAGTTATTC
CGAATTTAGAGGATAAAAATATTCCTGAGTTTGCAAGCATTAGTGCGGAACAAGCAGAAACGATTGCAAAGGCAGATATT
GAAAAAGAATTGGGTAAAGTAAAGAATTATGACGGTGTGAAAAAAGATTTATTTGTTTATGAAAAAGATGGAAAATACTA
TCTTGCATATTTAGTGAAAGCGTCGATTTCAAAACCAGCTCCAGGATATTGGCATTATTTTGTTGATGCAACGAATGGAA
ATGTGATTGAGAAATATAATGCTGTAGATCATATTACAGGATTTGGTTACGAAGTACTAGGAGCTAGACAATCATTTGAA
ATTGCTCAAGATGAGAAAACAGGAGCATTCAACTTATTTGACGGGAAACGAGGACAAGGTGTTCATACATTTGATGCAGA
TAATATGGATGAAAATTTATTTAACATATTCTCGCAATGGTTTGGATATACAGGTCTAGAAGTAGAAAGTAAAAATAAAT
TCTTTGATGACAAAGCGGCGGTTGATGCGCATGTAAACGCAGGAAAAGTATATGATTACTACAAAAAGACATTTAATCGT
AACTCGTTCGATGATAAAGGTGCGAAACTTATTTCCTCTGTTCACGTAGGTGAAAACTGGAATAACGCAGCTTGGAATGG
TGTGCAAATGATGTATGGTGATGGCGATGGTACAACATTTATTTCATTATCTGCTGGATTAGATGTTATCGGTCACGAAT
TAACGCATGCTGTAACGGAACATACAGCAAATCTTGTTTATAAAAATGAGTCAGGTGCGTTAAATGAATCGTTATCTGAT
ATTATGGGTGTCATGGTTGAGAAGAAGAGTTGGGATTTAGGTGCTGACATTTATACACCTGGAAAACCTGGTGATGCACT
TCGTTCTCTGAAAGATCCAGCGTCTATTCCAAATCCATTAAAACCAGGTGAAGGTTACCCTGATCATTACAATAAACGCT
ACACTGGAACAGCTGATAATGGCGGCGTTCATATTAACAGTAGTATTAACAATAAAGCTGCCTATTTAGTGTCTGATGGT
GGAGAGCATTACGGTGTGAAAGTAACTGGAGTTGGCCGTGAAGCGACAGAGAAAATTTATTACCGTGCTCTTACGAAATA
TTTAACTGCAAACTCTGACTTCAAAATGATGCGTCAAGCGGCACTTCAGTCAGCTGAAGATTTATATGGTAAAGATTCTA
AAGCTGTACAAGCTGTAACGAAAGCTTATGATGCAGTAGGCGTAAAATAA

Upstream 100 bases:

>100_bases
TGTCAGAAAAAACTTTCTCAAATTATGGAAAAAGGTATTGGCTAAAAAATAAGAATTGTATAAAAGTGTCAAAAATCTTT
AGGGAATGGGGAATGTTATA

Downstream 100 bases:

>100_bases
TAAGAGAAAAAGACCTGACTAGAATGTCAGGTCTTTCTGTATTTAGTCGCGAATACCTAATGCGATTTTCGCCATACGTG
ACATGCGTTCTTTAGACCAT

Product: neutral protease B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKLAGNID
KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADI
EKELGKVKNYDGVKKDLFVYEKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFE
IAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQWFGYTGLEVESKNKFFDDKAAVDAHVNAGKVYDYYKKTFNR
NSFDDKGAKLISSVHVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSD
IMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYLVSDG
GEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK

Sequences:

>Translated_549_residues
MKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKLAGNID
KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADI
EKELGKVKNYDGVKKDLFVYEKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFE
IAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQWFGYTGLEVESKNKFFDDKAAVDAHVNAGKVYDYYKKTFNR
NSFDDKGAKLISSVHVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSD
IMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYLVSDG
GEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK
>Mature_549_residues
MKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKLAGNID
KHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADI
EKELGKVKNYDGVKKDLFVYEKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFE
IAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQWFGYTGLEVESKNKFFDDKAAVDAHVNAGKVYDYYKKTFNR
NSFDDKGAKLISSVHVGENWNNAAWNGVQMMYGDGDGTTFISLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSD
IMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYLVSDG
GEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK

Specific function: Unknown

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: NA

Molecular weight: Translated: 60640; Mature: 60640

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
TVFQYLESKKDMFKLAGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLD
HHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCEEEEEEEECCCCCEECCCCEEEEC
KENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKELGKVKNYDGVKKDLFVY
CCCCHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
EKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFE
ECCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCEEEHHCCHHHHCCCCHHHHCCCCCCC
IAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQWFGYTGLEVESKNKFFDDKAA
CCCCCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHH
VDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSVHVGENWNNAAWNGVQMMYGDGDGTTF
EECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEE
ISLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKSWDLGADIYTP
EEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYLVSDG
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECC
GEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVT
CCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KAYDAVGVK
HHHHHCCCC
>Mature Secondary Structure
MKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
TVFQYLESKKDMFKLAGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTLD
HHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCEEEEEEEECCCCCEECCCCEEEEC
KENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKELGKVKNYDGVKKDLFVY
CCCCHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
EKDGKYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYEVLGARQSFE
ECCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCEEEHHCCHHHHCCCCHHHHCCCCCCC
IAQDEKTGAFNLFDGKRGQGVHTFDADNMDENLFNIFSQWFGYTGLEVESKNKFFDDKAA
CCCCCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHH
VDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSVHVGENWNNAAWNGVQMMYGDGDGTTF
EECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEE
ISLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKSWDLGADIYTP
EEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYLVSDG
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECC
GEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVT
CCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KAYDAVGVK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917867; 9025291; 9353931; 9384377 [H]