Click here to switch to the map view.

The map label for this gene is pgcA [H]

Identifier: 227817690

GI number: 227817690

Start: 4680499

End: 4682079

Strand: Reverse

Name: pgcA [H]

Synonym: BAMEG_5210

Alternate gene names: 227817690

Gene position: 4682079-4680499 (Counterclockwise)

Preceding gene: 227817691

Following gene: 227817689

Centisome position: 89.52

GC content: 38.84

Gene sequence:

>1581_bases
ATGCGTGGTGAACTTGGTGCTGGTACGAACCGTTTGAACGTATATACAGTTCGTAAAGCAACACAAGGATTAGCGAAGTT
TATTGAAAAGTTAGGTGAAGAAGCGAAGAAGCGCGGTGTTGTTGTAGCGTATGATTCTCGCCATAAATCACCTGAGTTCG
CAATGGAAGTAGCAGCTACACTTGGTGCACACGGCATTACAACATATGTGTTTGAAAGCTTACGCCCAACGCCAGTGCTT
TCTTTCGCAGTTCGTCATTTACATACAGTGAGTGGAATCGTTCTTACGGCAAGCCATAATCCGCCTGAATATAACGGTTA
TAAAGTATATGGTGAAGATGGTGGGCAGTTGCCTCCGAAAGAAGCTGATGAATTAATTAGCTATGTAAACGCAGTAGAAG
ATGAATTAACAGTTGAAGTTGCTGATGTAGAGCAATTAAAAGCTGACGGTTTATTACATATGATTGGACAAGAAGTAGAT
GATGCATATGCTGCAGAATTGAACAATGTCATTATTAATAAAGAAATGGTACAAAAGGTTGGGAAAGACTTAAAAATCGT
CTTCACACCACTACACGGAACATCAAATCTTTCTGTACGCCGTGGTTTAGCAGAAGTTGGATTTACAGATGTAACAGTTG
TAAAAGAGCAAGAGTTACCAGATCCGAATTTCTCTACAGTGAAATCACCGAACCCAGAAGAGCATGCAGCGTTTGAATAT
GCAATTCGTGACGGTGAGAAGGTAGGCGCAGATGTGTTAATCGCAACAGATCCTGACGCAGACCGCCTTGGTGTAGCAGT
TCGTAATCATGATGGTGAGTTCCAAGTATTAACTGGTAACCAAACAGGTGCATTAATGCTTGATTACTTATTATCTCAAA
AGAAAGAAAACGGAACGCTTCCAGAGAACGGTGTTGTATTAAAAACAATCGTAACATCTGAGATTGGCCGTACAATCGCG
AAAGCATACGGTTTAGATACAGTTGATACGTTAACTGGATTTAAATTTATCGGTGAGAAAATTAAACAGTATGAAGAAAG
CGGACAATACGAATTCCAATTCGGTTATGAGGAAAGCTATGGTTATTTAATCCGTCCATTCTGCCGTGATAAAGATGCAG
TACAATCTGTTCTATTTGCATGTGAAGTAGCTGCATACTACAAATCACAAGGTAAAACGTTATACGATGGTCTATTAGAA
GTATTTGAGAAGTACGGTTTCTTCCGTGAAGATCTTGTATCGTTAACGCTAAAAGGAAAAGATGGAGCGGAACAAATTCA
AGAAATGATGGCAACATTCCGTGAAAATCCTCCGAAAGAAGTAGCTGGCTTAACAGTTGTAGCAGTTGAAGACTATAAAG
CGAGCATCATTACATCTTTACAAGATGGACATAAAGAAGAGATTCACTTACCGAAATCAAATGTGTTAAAATATCAATTA
GAAGATGGTTCTTGGTTCTGCCTACGTCCATCTGGAACTGAACCGAAGATCAAGTTCTACTTCGGTGTTCAAGATAATTC
TTTACAAAATAGTGAACAAAAGTTACTTACTATTAAAGAAGATATTATGAATCGTTTATAA

Upstream 100 bases:

>100_bases
AGTTAGACGCAGAACTAAAAGAACAGTTAGAAAACATGAAGCAAGATGAGAAAAAATCGAGGACAGCTTTTATAAAAATC
TAGAATTTGGCACAGGTGGT

Downstream 100 bases:

>100_bases
TATAAAGTAATTTTAAGTAGTAGGAAACAAAAGGGAGCGAAACCTCCCTTTTGTTCTATGTAAGGAAATAATCGTTATTG
ATTCTGACAGAAGAGAGGGT

Product: phosphomannomutase, putative

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MRGELGAGTNRLNVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVL
SFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHMIGQEVD
DAYAAELNNVIINKEMVQKVGKDLKIVFTPLHGTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEY
AIRDGEKVGADVLIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIA
KAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLE
VFEKYGFFREDLVSLTLKGKDGAEQIQEMMATFRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQL
EDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL

Sequences:

>Translated_526_residues
MRGELGAGTNRLNVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVL
SFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHMIGQEVD
DAYAAELNNVIINKEMVQKVGKDLKIVFTPLHGTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEY
AIRDGEKVGADVLIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIA
KAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLE
VFEKYGFFREDLVSLTLKGKDGAEQIQEMMATFRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQL
EDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL
>Mature_526_residues
MRGELGAGTNRLNVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVL
SFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHMIGQEVD
DAYAAELNNVIINKEMVQKVGKDLKIVFTPLHGTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEY
AIRDGEKVGADVLIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIA
KAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLE
VFEKYGFFREDLVSLTLKGKDGAEQIQEMMATFRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQL
EDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=519, Percent_Identity=34.6820809248555, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI63055049, Length=516, Percent_Identity=31.2015503875969, Blast_Score=261, Evalue=2e-69,
Organism=Escherichia coli, GI1786904, Length=505, Percent_Identity=25.5445544554455, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993870, Length=539, Percent_Identity=31.5398886827458, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71993878, Length=294, Percent_Identity=31.6326530612245, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323934, Length=546, Percent_Identity=31.3186813186813, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20129809, Length=514, Percent_Identity=29.1828793774319, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24651977, Length=443, Percent_Identity=29.7968397291196, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24653722, Length=514, Percent_Identity=27.431906614786, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 58368; Mature: 58368

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGELGAGTNRLNVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAAT
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
LGAHGITTYVFESLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPK
HCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCH
EADELISYVNAVEDELTVEVADVEQLKADGLLHMIGQEVDDAYAAELNNVIINKEMVQKV
HHHHHHHHHHHHHHHHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEECHHHHHHC
GKDLKIVFTPLHGTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEY
CCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
AIRDGEKVGADVLIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTL
HHCCCCCCCCEEEEEECCCCHHHEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCC
PENGVVLKTIVTSEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESY
CCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
GYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGK
CCEEEHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEEEEECCC
DGAEQIQEMMATFRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQL
CCHHHHHHHHHHHHCCCCHHHHCEEEEEECCHHHHHHHHHHCCCCCEEECCCCCEEEEEE
EDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL
CCCCEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGELGAGTNRLNVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAAT
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
LGAHGITTYVFESLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPK
HCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCH
EADELISYVNAVEDELTVEVADVEQLKADGLLHMIGQEVDDAYAAELNNVIINKEMVQKV
HHHHHHHHHHHHHHHHEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEECHHHHHHC
GKDLKIVFTPLHGTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEY
CCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
AIRDGEKVGADVLIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTL
HHCCCCCCCCEEEEEECCCCHHHEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCC
PENGVVLKTIVTSEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESY
CCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
GYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGK
CCEEEHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEEEEECCC
DGAEQIQEMMATFRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQL
CCHHHHHHHHHHHHCCCCHHHHCEEEEEECCHHHHHHHHHHCCCCCEEECCCCCEEEEEE
EDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL
CCCCEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]