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The map label for this gene is loN [H]

Identifier: 227817250

GI number: 227817250

Start: 4278161

End: 4279792

Strand: Reverse

Name: loN [H]

Synonym: BAMEG_4737

Alternate gene names: 227817250

Gene position: 4279792-4278161 (Counterclockwise)

Preceding gene: 227817251

Following gene: 227817249

Centisome position: 81.83

GC content: 40.56

Gene sequence:

>1632_bases
ATGAAGGCGATTCAAACTGAACTTGGCGATAAAGAAGGCAAGGGCGGGGAAGTTGAAGAACTTCGTGAGAAAATTGAACA
GTCAGGAATGCCTGAAGAAACAATGAAGGCTGCGCTGAAAGAATTAGATCGTTATGAAAAGTTACCAGCAAGTTCTGCGG
AGAGCGGTGTTATTCGCAATTATATGGATTGGTTATTAGCACTTCCGTGGACAGACGCAACGGAAGATATGATTGATCTT
GCTCATTCGGAAGAGATTTTAAACAAAGATCATTACGGTCTTGAGAAAGTGAAAGAGCGCGTACTGGAATATTTAGCGGT
ACAGAAGTTAACGAATTCATTAAAAGGGCCTATCCTTTGTTTAGTAGGGCCACCTGGGGTCGGAAAAACTTCGTTAGCGC
GTTCTATTGCGACATCATTAAATCGTAATTTTGTCCGTGTATCCCTTGGTGGTGTGCGTGATGAATCTGAAATTCGTGGT
CACCGTCGTACGTACGTTGGAGCAATGCCAGGACGCATTATTCAAGGTATGAAAAAGGCAAAATCAGTTAATCCAGTCTT
CTTATTAGATGAGATTGATAAAATGTCTAACGATTTCCGTGGAGATCCTTCAGCAGCATTACTTGAAGTGTTAGATCCAG
AACAAAACCATAACTTCAGTGATCATTATATTGAAGAACCATATGATCTATCGAAAGCTATGTTTGTAGCAACTGCGAAT
ACACTTTCAAGTATTCCAGGTCCATTACTTGACCGTATGGAAATTATTTCGATTGCTGGCTATACAGAACTTGAAAAAGT
TCATATTGCTCGTGAACATTTATTGCCGAAACAATTACAAGAGCATGGCTTACGAAAAGGTAATTTACAAGTACGTGATG
AAGCGCTTCTTGAAATTATTCGCTATTATACACGTGAGGCTGGTGTTCGTACACTAGAGCGCCAAATTGCAAAGGTTTGT
CGTAAAGTAGCAAAAATTATCGTTACAGCAGAACGTAAGCGTATTGTAGTAACAGAGAAAAACGTTGTTGATTTACTTGG
TAAGCACATATTCCGTTATGGGCAAGCTGAAAAAACAGACCAAGTTGGTATGGCGACGGGTTTAGCGTATACGGCAGCAG
GCGGCGATACACTGGCGATTGAAGTGTCCGTAGCGCCAGGTAAAGGGAAATTAATTTTAACAGGGAAACTTGGGGATGTT
ATGAAAGAATCCGCACAAGCAGCGTTTAGCTATATTCGTTCTCGTGCAGAAGAGCTTCAGATTGATCCGAATTTCCATGA
GAAAAATGATATTCATATTCATGTTCCAGAAGGAGCAGTTCCAAAAGATGGACCGTCAGCAGGTATTACGATGGCAACGG
CACTTATTTCTGCGTTAACAGGTATTCCTGTAAGTAAAGAAGTGGGGATGACAGGTGAAATTACACTTCGTGGTCGTGTA
TTACCGATTGGTGGTTTAAAAGAAAAAACATTAAGTGCTCACCGCGCAGGTTTAACAAAAATTATTTTACCGGCGGAAAA
TGAGAAAGATTTAGATGATATTCCAGAGAGCGTAAAAGAAAACCTTACGTTTGTGCTTGCATCTCATTTAGATGAAGTAT
TGGAGCACGCATTAGTAGGAGTGAAACAATGA

Upstream 100 bases:

>100_bases
CAAGATGAACAAGAATTACTTAGTTTAGAAAAGAAAATTGGACAAAAAGTGAAACGTTCAATGGAGCGCACGCAAAAAAG
AATATTTCTTGCGTGAGCAA

Downstream 100 bases:

>100_bases
AAGTAACAAAAGCAGACATTGTAATTAGTGCTGTTAAACCAGAACAATATCCAGACGGTGACTTACCAGAAATCGCATTA
GCAGGTCGTTCAAATGTCGG

Product: ATP-dependent protease La 1

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDL
AHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRG
HRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKAMFVATAN
TLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVC
RKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDV
MKESAQAAFSYIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRV
LPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Sequences:

>Translated_543_residues
MKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDL
AHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRG
HRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKAMFVATAN
TLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVC
RKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDV
MKESAQAAFSYIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRV
LPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
>Mature_543_residues
MKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDL
AHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRG
HRRTYVGAMPGRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKAMFVATAN
TLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVC
RKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDV
MKESAQAAFSYIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRV
LPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=565, Percent_Identity=49.7345132743363, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI21396489, Length=548, Percent_Identity=46.3503649635037, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=539, Percent_Identity=57.8849721706865, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=580, Percent_Identity=42.9310344827586, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=534, Percent_Identity=44.5692883895131, Blast_Score=459, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319449, Length=601, Percent_Identity=39.7670549084859, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI221513036, Length=555, Percent_Identity=47.027027027027, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=555, Percent_Identity=47.027027027027, Blast_Score=523, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 59760; Mature: 59760

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRN
CCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
YMDWLLALPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILC
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKA
EECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHH
KSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKAMFVATAN
CCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHH
TLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEII
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHH
RYYTREAGVRTLERQIAKVCRKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCC
QVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQ
HHHHHHCCEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEE
IDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRV
CCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEE
LPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVG
EECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VKQ
CCC
>Mature Secondary Structure
MKAIQTELGDKEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRN
CCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
YMDWLLALPWTDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILC
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKA
EECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHH
KSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKAMFVATAN
CCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHH
TLSSIPGPLLDRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEII
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHH
RYYTREAGVRTLERQIAKVCRKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCC
QVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQ
HHHHHHCCEEEECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEE
IDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRV
CCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEE
LPIGGLKEKTLSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVG
EECCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VKQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA