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The map label for this gene is hemE [H]

Identifier: 227816079

GI number: 227816079

Start: 3186728

End: 3187699

Strand: Reverse

Name: hemE [H]

Synonym: BAMEG_3505

Alternate gene names: 227816079

Gene position: 3187699-3186728 (Counterclockwise)

Preceding gene: 227816080

Following gene: 227816078

Centisome position: 60.95

GC content: 39.4

Gene sequence:

>972_bases
ATGCGTCAAGCAGGTCGTTCGCAGCCGGAATATAGAAAGATAAAAGAAAAGTATTCTTTATTTGAAATTACACATAATCC
AGAGTTATGTGCTTACGTTACAAAACTACCAGTTGATCAATATAACGTAGACGCAGCAATTCTTTATAAAGATATTATGT
CACCACTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGATAATCCAATCCGTTCTTTA
CAAGACGTAGAAAAACTAGGGGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATACAATTCGTTTATTAACGAC
TGAAATGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTATATGATTGAAGGCGGTCCAT
CTCGTAACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTTGCTTTAATCGATAAGCTAGCAGAT
ATGGTTATTACATATTTGAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCGATTCTTGGGTTGGAACAGT
AAACGTAGCAGATTACCGCGTATTTATTAAACCAGCAATGGAGCGTATTTTTGCAGAAGTTCGCACAATGGGTGTACCGA
TGATTATGCACGGCGTAGGAGCTGCACACTTAGTGAATGAGTGGCACGACTTACCGCTTGATGTAGTCGGTTTAGACTGG
CGTTTACCAATTGAAGAAGCACGTGCACGCGGCGTTCACAAGGCGGTACAAGGGAATATGGATCCGTCATTCTTACTTGC
ACCATGGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAGCAGCCAGGTTATATCTTTAACTTAG
GTCACGGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAG
TTAGCGAAGTAA

Upstream 100 bases:

>100_bases
TGTGGTAAGGAAGGGAGCTAGGGTCTTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTG
ATTATGTGCCAGCATGGTAT

Downstream 100 bases:

>100_bases
AGGAGCATTGCTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALIDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK

Sequences:

>Translated_323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALIDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK
>Mature_323_residues
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSL
QDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALIDKLAD
MVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQ
LAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=330, Percent_Identity=34.8484848484849, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI2367337, Length=325, Percent_Identity=40.9230769230769, Blast_Score=233, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320252, Length=331, Percent_Identity=32.3262839879154, Blast_Score=172, Evalue=8e-44,
Organism=Drosophila melanogaster, GI221330099, Length=324, Percent_Identity=32.4074074074074, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19921920, Length=324, Percent_Identity=32.4074074074074, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 36192; Mature: 36192

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIG
CCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
VDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGA
CCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCC
PFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALIDKLADMVITYLKAQINAGAKAVQIF
CHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCEEEEECCC
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPE
CCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
VNPDTLKRLTTFIHEYSKGQLAK
CCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSPLPAIG
CCCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
VDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGA
CCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCC
PFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALIDKLADMVITYLKAQINAGAKAVQIF
CHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMIMHGVGAAHLVNEWHDLPLDVVGLDW
HHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCEEEEECCC
RLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGHGVFPE
CCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
VNPDTLKRLTTFIHEYSKGQLAK
CCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA