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The map label for this gene is ilvC1

Identifier: 227815753

GI number: 227815753

Start: 2895527

End: 2896537

Strand: Reverse

Name: ilvC1

Synonym: BAMEG_3176

Alternate gene names: 227815753

Gene position: 2896537-2895527 (Counterclockwise)

Preceding gene: 227815754

Following gene: 227815752

Centisome position: 55.38

GC content: 40.36

Gene sequence:

>1011_bases
ATGGCAAAAGTTTATTATGAAAAAGATGTAACGGTAAATGTATTAAAGGAAAAGAAAGTAGCAATCATTGGATATGGCTC
GCAAGGTCATGCACATGCGCAAAATTTACGTGATAACGGATTTGATGTAGTAGTAGGTTTAAGAAAAGGGAAGTCTTGGG
ATAAAGCGAAAGAAGATGGATTTTCTGTATATACAGTAGCGGAAGCAGCAAAACAGGCTGATGTAGTAATGATTTTGCTA
CCGGATGAACTGCAACCAGAAGTATATGAAGAGGAAATTGCGCCAAATTTACAGGCAGGAAATTCTCTCGTTTTTGCACA
CGGATTTAATGTTCACTTTGATCAAGTGAAACCACCAGTGAATGTAGATGTATTTCTAGTAGCACCAAAAGGTCCAGGAC
ATCTTGTGCGTCGTACGTTTAGTGAGGGCGGAGCTGTTCCTGCATTATTTGCAGTATATCAAGATGCAACAGGAGTTGCG
ACTGAAAAGGCACTTTCTTATGCTGATGGAATTGGAGCGACGAGAGCTGGTGTATTAGAAACGACATTTAAAGAAGAAAC
GGAAACAGATTTATTTGGAGAGCAAGCAGTACTTTGCGGCGGAGTAACTGCGCTAGTCAAAGCTGGATTTGAAACGTTAG
TTGATGCCGGATATCAGCCGGAACTTGCATATTTTGAATGTTTACATGAACTGAAACTTATTGTTGACCTTATGTATGAA
GGTGGACTTGAAAATATGAGATATTCAGTTTCAGATACAGCGCAGTGGGGCGACTTCGTATCAGGACCACGTGTTGTAAC
AGAAGATACGAAGAAAGCGATGGGTACAGTGCTAGCAGAAATTCAAGATGGTACATTTGCAAGAGGTTGGATTGCAGAGC
ATAAAGCAGGAAAACCAAATTTTTATGCGACAAATGAAAAAGAGAATGAACATGAAATCGAAGTAGTTGGACGTAAATTA
CGTGGAATGATGCCTTTCGTACAGCCGCGAGTAAAGGCAGGGGTCAAATAA

Upstream 100 bases:

>100_bases
TTGCAAGAACAGGGGTAACAGCCTTTACGCGTAGCATGAAAAAGCAAGATAAGCAAGTAATGTTAATTCAATAATCATTT
AAATATAGGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TATGAAGCAAATTTTGTTCATGGATACGACGCTACGTGATGGCGAACAATCACCAGGAGTAAATTTAAATGAACAAGAGA
AATTGCAAATTGCAAGGCAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 1; Alpha-keto-beta-hydroxylacil reductoisomerase 1

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPNFYATNEKENEHEIEVVGRKL
RGMMPFVQPRVKAGVK

Sequences:

>Translated_336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPNFYATNEKENEHEIEVVGRKL
RGMMPFVQPRVKAGVK
>Mature_335_residues
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLP
DELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVAT
EKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEG
GLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPNFYATNEKENEHEIEVVGRKLR
GMMPFVQPRVKAGVK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.8122866894198, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=34.8348348348348, Blast_Score=159, Evalue=8e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC1_BACAN (Q81T69)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843876.1
- RefSeq:   YP_018040.1
- RefSeq:   YP_027579.1
- ProteinModelPortal:   Q81T69
- SMR:   Q81T69
- EnsemblBacteria:   EBBACT00000010159
- EnsemblBacteria:   EBBACT00000015158
- EnsemblBacteria:   EBBACT00000023847
- GeneID:   1084747
- GeneID:   2816383
- GeneID:   2851032
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1419
- KEGG:   bar:GBAA_1419
- KEGG:   bat:BAS1310
- TIGR:   BA_1419
- TIGR:   GBAA_1419
- GeneTree:   EBGT00050000000943
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   BANT260799:BAS1310-MONOMER
- BioCyc:   BANT261594:GBAA1419-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36693; Mature: 36562

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CCEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV
CEEEEHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCEEEHHCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPN
CCCCCCEECCCCCHHHCHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCC
FYATNEKENEHEIEVVGRKLRGMMPFVQPRVKAGVK
EEECCCCCCCHHHHHHHHHHHCCCCHHCHHHHCCCC
>Mature Secondary Structure 
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV
CEEEEHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCEEEHHCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPN
CCCCCCEECCCCCHHHCHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCC
FYATNEKENEHEIEVVGRKLRGMMPFVQPRVKAGVK
EEECCCCCCCHHHHHHHHHHHCCCCHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629