Click here to switch to the map view.

The map label for this gene is hisD

Identifier: 227815746

GI number: 227815746

Start: 2887425

End: 2888714

Strand: Reverse

Name: hisD

Synonym: BAMEG_3169

Alternate gene names: 227815746

Gene position: 2888714-2887425 (Counterclockwise)

Preceding gene: 227815747

Following gene: 227815745

Centisome position: 55.23

GC content: 38.37

Gene sequence:

>1290_bases
ATGGAGATAGTTTGTGAGGATTTTCAAAAGGCGTTAACGAAAATAAAACTGTTACGAGAAAACGCTAATATAATAGAAGA
AACTGTTCAAAGAAGTGTCAGGGAAATCGTTCAGAATGTAAGAGAGAGTAGAGATGAGGCGTTATCTTTCTATACAAAAA
AGTTTGATGGTGTAGAGATTAAAGATGTTCGTGTAAGTGAAGAAGAAATAAAACAAGCGAGTATGTTTGTAGAGAGTTCA
TTTTTAGAAGCGTTACAAGAGGCGAAGAAAAACATTATTTCGTACCATGAAAAGCAAAAAAGACAATCGATGTTTGATTG
CACGAGTAAAGGCATCATAAGGGGACAAATCATTCGGCCGTTAGAAAATATAGGGGTATATGTGCCAGGCGGAACTGCTT
CGTATCCTTCGTCAGTATTAATGAATGTATTGCCAGCAAAGCTCGCGGGTGTGAAAAAGATTGTAATGGTAACACCGCCA
AGAGCAGGAGGAATTGATCCGCATATTTTAGTTGCTGCAAGCCTTGCAGGAGTAGATGAAATTTATATGATAGGTGGCGC
GCAAGCAATTGCTGCTTTAGCATACGGGACGGAATCGATTCCAAAAGTAGATAAAATAGTTGGACCAGGAAATTTGTACG
TCGCTCTAGCGAAACGAGAAGTATACGGAATAGTAAATATCGATATGATTGCTGGACCGTCAGAAATAGTAGTTATTGCT
GATGAAACTGGCAATGCAAAATATATTGCTGCAGATTTATTATCACAAGCAGAACATGATGAGAGAGCGACAGCAATTTG
TATTACAACGAATATAGAATTAGCAAAAGAAGTAGAAAAAGAGATAGAAAGGCAGTTAGAAACATTACCAAGAAGCGAAA
TTGCACGTGAATCAATAAATAGAAATGGAGCCATTTTTATCGTTCCTTCTATAGATGAGGCACTACAGTTATCGAATGAA
ATCGCCCCGGAACATTTAGAGTTACATATAAAAGAACCGATGAATGCTCTAGCTTATGTGAAACATGCAGGATCTATCTT
TCTTGGACCGTATGCACCAGAACCGCTCGGTGATTATTTAGCGGGACCGAATCATGTATTACCGACAAGTGGAACGGCAA
GGTTTTTCTCGCCGTTATCAGTCGATGATTTCGTGAAAAAATCAAGTTTTCTATCTTATACGGAGGGAGCATTAAGAGAT
GTAAAACATCATATTGTAGAACTTGCCAATAAAGAAGGGCTACATGCGCATGCGAGAGCAATTCAAATAAGATTTGGGGA
GGAAGAATAA

Upstream 100 bases:

>100_bases
TTGTAAATAAGGCTGCCTTAAAAACTAAAAAAGACGAAATATTCAGTATTATAAATATGATGGAGCAAGAAATTTTGTCA
GGAAAATAGGGGGACTTGTA

Downstream 100 bases:

>100_bases
TGCGGGAGTCTAGTCAAATACGTGAGACGACAGAAACAAAAATAAAATTAAGTTTGCAGCTTGATGAAGGAAAGAACGTT
TCTGTACAAACGGGAGTTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEGALRD
VKHHIVELANKEGLHAHARAIQIRFGEEE

Sequences:

>Translated_429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEGALRD
VKHHIVELANKEGLHAHARAIQIRFGEEE
>Mature_429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEGALRD
VKHHIVELANKEGLHAHARAIQIRFGEEE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=412, Percent_Identity=40.7766990291262, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=432, Percent_Identity=37.7314814814815, Blast_Score=281, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BACAN (Q81T62)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843883.1
- RefSeq:   YP_018047.1
- RefSeq:   YP_027586.1
- ProteinModelPortal:   Q81T62
- SMR:   Q81T62
- EnsemblBacteria:   EBBACT00000009758
- EnsemblBacteria:   EBBACT00000017838
- EnsemblBacteria:   EBBACT00000019386
- GeneID:   1085728
- GeneID:   2814920
- GeneID:   2850851
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1426
- KEGG:   bar:GBAA_1426
- KEGG:   bat:BAS1317
- TIGR:   BA_1426
- TIGR:   GBAA_1426
- GeneTree:   EBGT00050000002843
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   BANT260799:BAS1317-MONOMER
- BioCyc:   BANT261594:GBAA1426-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47184; Mature: 47184

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 324-324 ACT_SITE 325-325 BINDING 127-127 BINDING 188-188 BINDING 211-211 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 325-325 BINDING 358-358 BINDING 412-412 BINDING 417-417

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEI
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
KDVRVSEEEIKQASMFVESSFLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRAGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCC
IYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
EEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSIDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEGALRDVKHHIVELANKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IQIRFGEEE
EEEEECCCC
>Mature Secondary Structure
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEI
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
KDVRVSEEEIKQASMFVESSFLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRAGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCC
IYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
EEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSIDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEGALRDVKHHIVELANKEGLHAHARA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IQIRFGEEE
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629