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The map label for this gene is murE [H]

Identifier: 227814595

GI number: 227814595

Start: 1823955

End: 1824254

Strand: Reverse

Name: murE [H]

Synonym: BAMEG_2005

Alternate gene names: 227814595

Gene position: 1824254-1823955 (Counterclockwise)

Preceding gene: 227814596

Following gene: 227814593

Centisome position: 34.88

GC content: 30.67

Gene sequence:

>300_bases
ATGGGTGGAATTGCTGGAAGTTATAGTGATTTTGTTTTTATTACTTCTGATAATCCACGTTCGGAAGATCCGCAGGCAAT
AATGAAAGATATTGAAAAAGGATTTTCGCAAAATAATAATTTGAATTATAAAGTGGAAGTAGATCGTGAACTTGCAATTA
ATCACGCAATAAACATGGCATCTTCTAATGATATTGTTTTGATTGCAGGGAAAGGGCATGAAACGTATCAAATTTTAAAA
GATTCAACTATTCATTTTGATGATAAAGAAAAAGCTCGACAAGCAATTATTAATAAATGA

Upstream 100 bases:

>100_bases
TTAGAAAATGTTCTCTCTACAATTAGAGAGTTTGCAAAAGGTAAAATTATTACTGTTTTCGGTTGTGGTGGAGATAGAGA
CGCAAAAAAAACGATCTATA

Downstream 100 bases:

>100_bases
ATTCAATTACTAGCTGAATAGTATTTCTAATAAAAATAATGTTTTAGATGAAGTAATAACAAAGCAATTTTTTGAAGAAT
TTATAATTGAAAGGTAAGGG

Product: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 99; Mature: 98

Protein sequence:

>99_residues
MGGIAGSYSDFVFITSDNPRSEDPQAIMKDIEKGFSQNNNLNYKVEVDRELAINHAINMASSNDIVLIAGKGHETYQILK
DSTIHFDDKEKARQAIINK

Sequences:

>Translated_99_residues
MGGIAGSYSDFVFITSDNPRSEDPQAIMKDIEKGFSQNNNLNYKVEVDRELAINHAINMASSNDIVLIAGKGHETYQILK
DSTIHFDDKEKARQAIINK
>Mature_98_residues
GGIAGSYSDFVFITSDNPRSEDPQAIMKDIEKGFSQNNNLNYKVEVDRELAINHAINMASSNDIVLIAGKGHETYQILKD
STIHFDDKEKARQAIINK

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786273, Length=89, Percent_Identity=41.5730337078652, Blast_Score=76, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR005761 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 11057; Mature: 10926

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGIAGSYSDFVFITSDNPRSEDPQAIMKDIEKGFSQNNNLNYKVEVDRELAINHAINMA
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHEECC
SSNDIVLIAGKGHETYQILKDSTIHFDDKEKARQAIINK
CCCCEEEEECCCCCEEEEECCCEECCCCHHHHHHHHCCC
>Mature Secondary Structure 
GGIAGSYSDFVFITSDNPRSEDPQAIMKDIEKGFSQNNNLNYKVEVDRELAINHAINMA
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHEECC
SSNDIVLIAGKGHETYQILKDSTIHFDDKEKARQAIINK
CCCCEEEEECCCCCEEEEECCCEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA