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The map label for this gene is proA [H]

Identifier: 227814204

GI number: 227814204

Start: 1478760

End: 1480004

Strand: Direct

Name: proA [H]

Synonym: BAMEG_1612

Alternate gene names: 227814204

Gene position: 1478760-1480004 (Clockwise)

Preceding gene: 227814203

Following gene: 227814207

Centisome position: 28.27

GC content: 39.36

Gene sequence:

>1245_bases
ATGAATGAAGTGTTAGCAAAGGGAAAGAAGGCGAAAGAGATCGCTAGAGAGCTAGTGCTTAAATCTACAGAGCAAAAAAA
CGAAGCACTTTCCGCAATAGCTGATCAGTTAATATTAGAAACAGCTTATATTTTAGAAGAAAATAAGAAGGATATTGAAG
AAGGTAAGGCAAAAGGGTTTTCTGATTCTCTCCTTGATCGCCTTATGCTGAATGAACAGCGTATTGTTGATATGACAGAA
GGGATTAAGCAGCTAATTGAATTACGTGATCCTGTAGGAGAATGTGTAAGTGCATGGGAAAGGCCAAATGGACTATCTAT
TCAGGAAATGCGCGTACCACTTGGTGTTGTTGGGATGATTTACGAGGCAAGACCGAATGTAACAGTGGATGCTGCTACAA
TTTGTTTGAAGACAGGAAACGCAGTCATATTACGTGGTAGTTCTTCTGCTATTCATTCTAATAAAGCCATCGTTGCCGTT
ATTCACAGAGCGCTCAAACAAACAAGCTTACCTCAAGAAAGTGTACAGCTTATAGAAGATACAACGCGAGATAGCGCAAA
GCAGTTGTTTACAATGAATGATTATCTAGACGTTCTTATTCCAAGAGGTGGCAAGCAATTAATCGATACTGTTGTGAGGG
AAGCGTCTGTCCCAGTACTTGAAACAGGTGCGGGAAATTGTCATGTTTTCATTGATGAAACAGCGGATAAACAAATGGCA
TTTGATATTATAAATGCAAAAACGCAGCGTCCATCTGTATGTAATGCAATTGAAACGATTGTACTTCATGAGAAGTGGGC
AGAGCAATATGGTAGCGAGTTGTTTTCTTCTTTGAAGAAAAGAGGCGTGGAGCTACGTGGTGATCAAAAAGCATTGGCAA
TGGATTCAACAATTGTACTTGCTTCAGAAGAAGACTGGGGGACAGAATTTTTATCTCTCACGCCAGCAGTTAAATTAGTT
TCTTCTATAGAAGAAGCGATTCATCACATAAATACGTATGGATCTATGCATTCTGAAGCGATTATTTCAGAAAACGAGGA
AAAAGTCAGCAAATTTTTCGTATCTGTTGATGCGGCTGCACTGTATCATAATGCATCAACTCGTTTTACTGATGGATCTG
AATTCGGATCTGGAGCAGAAATTGGTATCAGTACACAAAAGCTACACGTAAGAGGACCAATGGGGCTTCCTGCATTAACT
TCTACAAAATACGTCATTCGTGGAAATGGACAAATTCGAAAATAA

Upstream 100 bases:

>100_bases
AACAGATTCAAGCAAGAGGCGAAAGACATAATTATGAAGTCATTCATAGAGATTATTGGGTTTCATTTTAAGAAGATGGA
TCAAAAAGGAGGAAATAAAA

Downstream 100 bases:

>100_bases
AAATAAAAGACACTCAATTCGTTTGGGTGTCTTTTATTTTAAAAATTATTTACCATACAAAAAGCCCAACAAGCATAGCG
CTTAATAAGGAAACAGCCAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSTIVLASEEDWGTEFLSLTPAVKLV
SSIEEAIHHINTYGSMHSEAIISENEEKVSKFFVSVDAAALYHNASTRFTDGSEFGSGAEIGISTQKLHVRGPMGLPALT
STKYVIRGNGQIRK

Sequences:

>Translated_414_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSTIVLASEEDWGTEFLSLTPAVKLV
SSIEEAIHHINTYGSMHSEAIISENEEKVSKFFVSVDAAALYHNASTRFTDGSEFGSGAEIGISTQKLHVRGPMGLPALT
STKYVIRGNGQIRK
>Mature_414_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSTIVLASEEDWGTEFLSLTPAVKLV
SSIEEAIHHINTYGSMHSEAIISENEEKVSKFFVSVDAAALYHNASTRFTDGSEFGSGAEIGISTQKLHVRGPMGLPALT
STKYVIRGNGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=31.7073170731707, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=31.7073170731707, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=43.30900243309, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17569969, Length=409, Percent_Identity=34.2298288508557, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17569967, Length=409, Percent_Identity=34.2298288508557, Blast_Score=250, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=36.768149882904, Blast_Score=272, Evalue=8e-74,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=34.3065693430657, Blast_Score=258, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45436; Mature: 45436

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHH
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHH
FDIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSTIVL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEE
ASEEDWGTEFLSLTPAVKLVSSIEEAIHHINTYGSMHSEAIISENEEKVSKFFVSVDAAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
LYHNASTRFTDGSEFGSGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK
HHCCCCCCCCCCCCCCCCCEECCEEEEEEEECCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHH
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHH
FDIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSTIVL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEE
ASEEDWGTEFLSLTPAVKLVSSIEEAIHHINTYGSMHSEAIISENEEKVSKFFVSVDAAA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
LYHNASTRFTDGSEFGSGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK
HHCCCCCCCCCCCCCCCCCEECCEEEEEEEECCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA