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The map label for this gene is ycgH [H]

Identifier: 227814078

GI number: 227814078

Start: 1363220

End: 1363600

Strand: Direct

Name: ycgH [H]

Synonym: BAMEG_1485

Alternate gene names: 227814078

Gene position: 1363220-1363600 (Clockwise)

Preceding gene: 227814077

Following gene: 227814079

Centisome position: 26.06

GC content: 34.65

Gene sequence:

>381_bases
ATGGCTGTAGAAGATCCGCAAAAAGGATCTTTTCGCATATACTCAAAAAAAGCTTTTGGAAATTGGGCGGGTTTTAGTCA
TGGATGGACATATTGGTGTTCTGAACTGCTTATTATGGGCAGCCAGTTAAGTGCGTTAGGAATCTTTTCACGCTACTGGT
TTCCTAAAATACCGTTATGGATATTTGCTACTATATATGGAGTAGCGGCTATATTAATTATCTTTATAGGGGTAAAGATA
TTCGAACGTTTAGAAAAGTGGATGGCTATTATAAAAATCGCTGCTATTATGGGGTTTATTGTAATTGCTATTTTAGTTAT
TTTAGGATTTATAAAGGGTGGTTTATATAAAGCACAAATTCCGCAGAATTTTAAAGACTGA

Upstream 100 bases:

>100_bases
AGGATCCAGTATAGGAATTAAAATAGGTGGTTCGTCAATTATTCTTATTCTTATTTTAACTGGATTTACTACTTATATTG
TATTTGAAGCATTGGCAAAA

Downstream 100 bases:

>100_bases
TTCCCAAATGGATTAAAAGGTACTTGGTCCTCTCTAATTTATGCATTTTATGCATTTGGAGGAATCGAAATTATGGGGTT
AATGACAATAAGACTGAAAG

Product: amino acid permease

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 125

Protein sequence:

>126_residues
MAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKI
FERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD

Sequences:

>Translated_126_residues
MAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKI
FERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD
>Mature_125_residues
AVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKIF
ERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=101, Percent_Identity=38.6138613861386, Blast_Score=85, Evalue=1e-18,
Organism=Escherichia coli, GI1786789, Length=100, Percent_Identity=39, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1789017, Length=110, Percent_Identity=35.4545454545455, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI87081708, Length=112, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-15,
Organism=Escherichia coli, GI1788480, Length=113, Percent_Identity=30.9734513274336, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1786602, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=4e-13,
Organism=Escherichia coli, GI48994972, Length=111, Percent_Identity=32.4324324324324, Blast_Score=63, Evalue=7e-12,
Organism=Escherichia coli, GI1790653, Length=98, Percent_Identity=30.6122448979592, Blast_Score=61, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=109, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 14314; Mature: 14183

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLW
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
PQNFKD
CCCCCC
>Mature Secondary Structure 
AVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLW
CCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
PQNFKD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]