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The map label for this gene is proC2 [H]

Identifier: 227814062

GI number: 227814062

Start: 1348711

End: 1349175

Strand: Direct

Name: proC2 [H]

Synonym: BAMEG_1469

Alternate gene names: 227814062

Gene position: 1348711-1349175 (Clockwise)

Preceding gene: 227814060

Following gene: 227814063

Centisome position: 25.79

GC content: 37.63

Gene sequence:

>465_bases
ATGCCGAATACACCGGTACTTGTTGGGGAAGGAATGTCTGCATTATCTTTTAATGAAATGGTTACAGAAAAAGATATAAA
AGAGGTACTAAATATATTTAATAGTTTCGGCCAGACGGAGGTCGTAAATGAAAAATTAATGGATGTTGTTACATCTATTA
GTGGTTCTTCTCCAGCATATGTGTATATGTTTATAGAAGCCATGGCAGATGCTGCTGTACTTGACGGTATGCCGAGAAAA
CAGGCTTATAAATTTGCGGCTCAGGCTGTATTAGGTTCTGCAAAAATGGTATTGGAAACGGGAATACATCCAGGTGAATT
GAAGGATATGGTTTGTTCTCCAGGGGGAACGACGATAGAAGCTGTAGCAACATTAGAAGAAAAAGGTTTAAGAACAGCTA
TCATTTCAGCTATGAAACGTTGTACGAAAAAATCTATGGAAATGTCTCGTTTAACTAGTAAGTGA

Upstream 100 bases:

>100_bases
CCAAATAAAAAATGATGTAATTGTTGTAACTATTGCTGCAGGAAAAAGTATTAAGAGCACTGAGAATGAATTTGATAGAA
AGTTAAAGGTTATTAGAGTA

Downstream 100 bases:

>100_bases
GAAGATTTGTTTAGGCGTAACTTCATATCCATTAATGTAAGCTATTATTTAAATTAAAAGCTTGTTGCTATTCTCTTATA
GAGAGCGGGGCATAAAATTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRK
QAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK

Sequences:

>Translated_154_residues
MPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRK
QAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
>Mature_153_residues
PNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSPAYVYMFIEAMADAAVLDGMPRKQ
AYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIEAVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=150, Percent_Identity=41.3333333333333, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI21361454, Length=154, Percent_Identity=40.2597402597403, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI24797097, Length=154, Percent_Identity=39.6103896103896, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI24797095, Length=154, Percent_Identity=39.6103896103896, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1786585, Length=150, Percent_Identity=67.3333333333333, Blast_Score=213, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17540664, Length=165, Percent_Identity=40.6060606060606, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17569021, Length=145, Percent_Identity=42.0689655172414, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=150, Percent_Identity=31.3333333333333, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648116, Length=150, Percent_Identity=44, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647700, Length=149, Percent_Identity=44.2953020134228, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21358587, Length=149, Percent_Identity=44.2953020134228, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 16592; Mature: 16460

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
7.8 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSPAY
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHH
VYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHH
AVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PNTPVLVGEGMSALSFNEMVTEKDIKEVLNIFNSFGQTEVVNEKLMDVVTSISGSSPAY
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHH
VYMFIEAMADAAVLDGMPRKQAYKFAAQAVLGSAKMVLETGIHPGELKDMVCSPGGTTIE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHH
AVATLEEKGLRTAIISAMKRCTKKSMEMSRLTSK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]